Author(s):
Trhas Tesfay, Berihu Tekluu, Krishna Chaithanya K, Dhanunjaya Varma Lakkamraju, John Dogulas Palleti, Sudhish Rai, Kamalakararao K
Email(s):
kamalakar.kkr@gmail.com
DOI:
10.52711/0974-360X.2023.00876 
Address:
Trhas Tesfay1, Berihu Tekluu1, Krishna Chaithanya K1, Dhanunjaya Varma Lakkamraju2,3, John Dogulas Palleti3, Sudhish Rai4, Kamalakararao K5*
1Department of Chemistry, College of Natural and Computational Sciences, Aksum University, Axum, Tigray Region, Ethiopia.
2Department of Human Genetics, Andhra University, Visakhapatnam, A.P, India – 530003.
3Research and Development, Centre for Computational and Biological Sciences (CCBS), 48-12-16, Srinagar, Near RTC complex, Visakhapatnam - 530016, Andhra Pradesh, India.
4Department of Pharmacognosy, Tagore Institute of Pharmacy and Research, Bilaspur, Chhattisgarh, India.
5Department of Biochemistry, University College of Science and Technology, Adikavi Nannaya University, Rajamahendravaram, Andhra Pradesh, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 11,
Year - 2023
ABSTRACT:
Breast cancer is the leading cause of death in women. Currently existing chemopreventive and chemotherapeutic drugs promote resistance to breast treatment, and long-term usage results in unwanted side effects. Plant-derived anticancer agents have various advantages over chemical chemotherapeutic therapies, including lower cytotoxicity and higher pharmacological efficacy. Rumex abyssinicus (R. abyssinicus) has long been used as a traditional medicinal plant in Ethiopia for the treatment of infectious and non-infectious diseases. The purpose of this study is to evaluate the phytochemical analysis and investigate the in vitro cytotoxicity effect in MCF-7 breast cancer cell lines. R. abyssinicus dried roots powder was extracted with soxhlet from low polar to high polar solvents. Using established techniques, phytochemical screening of organic roots extracts of R. abyssinicus was performed. In vitro anticancer activities were evaluated by MTT assay. Among the organic root extracts of R. abyssinicus evaluated againstMCF-7 breast cancer cell lines, the chloroform extract displayed substantial in vitro cytotoxicity with an IC 50 value of 175.82g/ml. As a result, the researcher concluded that the chloroform extract of R. abyssinicus shown potential in vitro cytotoxicity in MCF-7 breast cancer cell lines.
Cite this article:
Trhas Tesfay, Berihu Tekluu, Krishna Chaithanya K, Dhanunjaya Varma Lakkamraju, John Dogulas Palleti, Sudhish Rai, Kamalakararao K. In vitro Anticancer activity of Rumex abyssinicus root extracts on breast cancer MCF-7 cell lines. Research Journal of Pharmacy and Technology. 2023; 16(11):5410-5. doi: 10.52711/0974-360X.2023.00876
Cite(Electronic):
Trhas Tesfay, Berihu Tekluu, Krishna Chaithanya K, Dhanunjaya Varma Lakkamraju, John Dogulas Palleti, Sudhish Rai, Kamalakararao K. In vitro Anticancer activity of Rumex abyssinicus root extracts on breast cancer MCF-7 cell lines. Research Journal of Pharmacy and Technology. 2023; 16(11):5410-5. doi: 10.52711/0974-360X.2023.00876 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-11-70
REFERENCES
1. Torre LA, Bray F, Siegel RL, Ferlay J, Lortet-Tieulent J, Jemal A. Global cancer statistics, 2012. CA Cancer Journal for Clinicians. 2015; 65(2): 87-108.
2. Bodai BI and Tuso P. Breast cancer survivorship; A comprehensive review on long –term medical issue and life style recommendations. Perm Medical Journal. 2015; 19(2): 48-79.
3. Nidarsan Viswanathan, V Gowri, K Punnagai. Investigation of In-vitro Antiproliferative activity of Ampelocissus latifolia root extract on MCF-7 breast cancer cells Ampelocissus latifolia root extract against MCF-7 breast cancer cells. Research Journal of Pharmacy and Technology. 2023; 16(8):3595-0.
4. Bukowski K, Kciuk M, Kontek R. Mechanisms of Multidrug Resistance in Cancer Chemotherapy. International Journal of Molecular Sciences. 2020; 21(9):3233.
5. Thakur, Vikram, Rajaletchumy Veloo Kutty. Recent advances in nanotheranostics for triple negative breast cancer treatment. Journal of Experimental and Clinical Cancer Research. 2019; 38(1): 430.
6. Karpagam T, Jannathul Firdous, Revathy, Shanmuga Priya, Varalakshmi B, Gomathi S, Geetha S, Noorzaid Muhamad. Anti-Cancer Activity of Aloe vera Ethanolic Leaves Extract against In vitro Cancer Cells. Research J. Pharm. and Tech. 2019; 12(5): 2167-2170.
7. Pereira AG, Chamorro F, Carpena M, Echave J, Fraga-Corral M, Simal-Gandara J, and Prieto MA. Status and Challenges of Plant-Anticancer Compounds in Cancer Treatment. Pharmaceuticals (Basel, Switzerland). 2021; 14(2), 157.
8. Ashpak M, Tamboli Kiran A, Wadkar. Anticancer activity of leaves extracts of Convolvulus pluricaulis and Mimosa rubicaulis (Lam.) by Brine Shrimp Lethality Bioassay. Research Journal of Pharmacy and Technology. 2021; 14(10): 5427-2.
9. Nidarsan Viswanathan, V Gowri, K Punnagai. Investigation of In-vitro Antiproliferative activity of Ampelocissus latifolia root extract on MCF-7 breast cancer cells Ampelocissus latifolia root extract against MCF-7 breast cancer cells. Research Journal of Pharmacy and Technology. 2023; 16(8): 3595-0.
10. Fullas F. A short Note on Meqmeqo (Rumexabyssinicus). November 22; 2015. (Accessed 2 January 2016) Available:http://www.ethiomedia.com/aa2nov15/4491.html.
11. Birhanu Z. Traditional use of medicinal plants by the ethnic groups of Gondar Zuria District, North Western Ethiopia. Journal of Natural Remedies. 2013; 13:2320-3358.
12. Gebeyehu G. Asfaw Z, Enyew A, Raja N. Ethnobotanical study of traditional medicinal plants and their conservation status in Mecha Woreda, West Gojjam Zone of Ethiopia. International Journal of Pharmaceuticals and Health Care Research. 2014; 2:137-154.
13. Behailu A, Moa M Tilahu Tolossa J. Ethnobotanical study of medicinal plants used to treat human diseases in Gura Damole District, Bale Zone, Southeast Ethiopia. Asian Journal of Ethnobiology. 2021; 4(1): 42-52.
14. Das S, Haldar PK, Pramanik G, Suresh R. Evaluation of anti-inflammatory activity of Clerodendron infortunatum Linn. Extract in rats Global J Pharmacol. 2010; 4(1): 48-5.
15. Razak NA, Abu N, Ho, WY, Zamberi NR, Tan SW, Alitheen NB, Long K, and Yeap SK. Cytotoxicity of eupatorin in MCF-7 and MDA-MB-231 human breast cancer cells via cell cycle arrest, anti-angiogenesis and induction of apoptosis. Scientific Reports. 2019; 9(1): 1514.
16. Abate A, Abebaw D, Birhanu A, Zerihun A, Assefa D. Prevalence and Associated Factors of Violence against Hospital Staff at Amanuel Mental Specialized Hospital in Addis Ababa, Ethiopia. Psychiatry Journal. 2019; 5(11), 1-11. https://doi.org/10.1155/2019/3642408
17. Hadera Brhane G, Zenebe H, Kidu H, Tesfay W, Tekleweyni T, Krishna Chaithanya K. Antioxidant and free radical scavengingactivities of Ethyl acetate leaf extract of Rumex nervosus. Drug Invention Today. 2020; 14(2): 11-16.
18. Lei Wang, Jianwei Xu, Ye Yan, Han Liu, Thiruventhan Karunakaran and Feng Li. Green synthesis of gold nanoparticles from Scutellariabarbata and its anticancer activity in pancreatic cancer cell (PANC‐1). Artificial Cells, Nanomedicine, and Biotechnology. 2019; 47(1): 1617-1627.
19. Sajuthi D. Extraction, fractionation, and in vitro biological tested on Gynura pseudochina (Linn.) DC. as anticancer, second phase. Buletin Kimia. 2001; 1(2): 10-19.