Author(s):
K. Prabakaran, M. Sathiyaseelan, S. Rameshkumar, A. Shiva Kumar
Email(s):
kpraba1985@gmail.com
DOI:
10.52711/0974-360X.2023.00807 
Address:
K. Prabakaran1*, M. Sathiyaseelan2, S. Rameshkumar3, A. Shiva Kumar1
1Department of Chemistry, Sri Indu College of Engineering and Technology (Autonomous),
Sheriguda (V), Hyderabad - 501510, Telangana, India.
2Department of Chemistry, Swami Dayananda College of Arts and Science, Manjakkudi, 612610
(Affiliated to Bharthidasan University), Tamil Nadu, India.
3Department of Physics, Sri Indu College of Engineering and Technology (Autonomous),
Sheriguda (V), Hyderabad-501510, Telangana, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 11,
Year - 2023
ABSTRACT:
Launaea nudicaulis is a significant medicinal plant with anti-inflammatory, anti-cancer, antidiabetic and antibacterial properties. In the present study, we have studied the phytochemical analysis of Launaea nudicaulis leaf extract by using NMR and GC-MS technique. According to the preliminary phytochemical analysis, identify the various active ingredients. For the purposes GC-MS study was suggested to look into the organic compounds of the unique drug Launaea nudicaulis. From the results, Launaea nudicaulis' ethanolic whole plant extract was found 11 different phytochemical compounds. The GC-MS analysis confirmed their presence various Phenyl methyl esters of 6, 9, and 12-octadecatrienoic acid (368) and Phytol (296) Molecular weight compounds. Squalene, an important chemical, was identified in the fraction using a GC-MS analysis, with an 80% match rate. By analyzing the extract using spectroscopy, 1HNMR 13C NMR and GC-MS techniques, the compound squalene could be identified.
Cite this article:
K. Prabakaran, M. Sathiyaseelan, S. Rameshkumar, A. Shiva Kumar. Evaluation of Phyto components in the Ethanolic Extract from Launaea Nudicaulis. Research Journal of Pharmacy and Technology 2023; 16(11):4989-2. doi: 10.52711/0974-360X.2023.00807
Cite(Electronic):
K. Prabakaran, M. Sathiyaseelan, S. Rameshkumar, A. Shiva Kumar. Evaluation of Phyto components in the Ethanolic Extract from Launaea Nudicaulis. Research Journal of Pharmacy and Technology 2023; 16(11):4989-2. doi: 10.52711/0974-360X.2023.00807 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-11-1
REFERENCES:
1. Koduru S. Grierson DS. Afolayan AJ. Antimicrobial activity of Solanum aculeastrum. Pharm. Biol. 2006; 44: 283-286.doi.10.1080/13880200600714145.
2. Dibyajyoti S. Swati P. Pharmacognostic Studies of Aerial Part of Methanolic Extract of Alpinia conchigera Griff), Asian Journal of Pharmaceutical Analysis. 2012; 2(2):46-48.doi.10.5958/2231–5675.
3. Deepak kumar,DN.Dua,JS. and Bhatnagar,S.P. Evalution of Wound healing activity of of Ethanolic Extractof Aerva tomentosa Forsk Research Journal of Pharmacognosy and Phytochemistry, 2009; 1(3): 188-190.doi.10.5958/0975-4385.
4. De-Fatima A. Modolo LV. Conegero LS. Pilli RA. Ferreira CV. Kohn LK. de-Carvalho JE Lactones and their derivatives: biological activities, mechanisms of action and Potential leads for drug design. Curr. Med. Chem. 2006; 13: 3371-3384.doi. 10.2174/092986706779010298.
5. Shahidi F. McDonald J. Chandrasekara A. Zhong Y. Phytochemicals of foods, Beverages and fruit vinegar: chemistry and health effects. Asia Pacific J. Clin. Nutr. 2008; 17: 380-382.doi.org/10.1016/j.jff.2015.06.018.
6. Baliga MS. Jagetia GC. Rao SK. Babu K. Evaluation of nitric oxide scavenging activity of certain spices in vitro: a preliminary study. Nahrung. 2003; 47(4): 261.doi. 10.1002/food.200390061.
7. Wagner H,Ulrich Mezenith, G.Synergy research :approaching a new generation of phytopharmaceuticals.Phytomedicine. 2009; 16: 97-100 doi.org/10.1016/j.phymed.2008.12.018.
8. Baquar SR. Medicinal and Poisonous Plants of Pakistan, Printas Press, Karachi, 1989. p.31.doi. 10.3923/ajb.2013.24.32
9. Krishnamurthi, The Wealth of India, Vol. I, Council of Scientific and Industrial Research, NewDelhi, 1969. p.68. doi.10.4236/msa.2018.910060.
10. S. Rashid, M. Ashraf, S. Bibi, and R. Anjum, Pak. J. Biol. Sci. 2000; 3: 630.doi. 10.3923/pjbs.2000.808.809.
11. S. Collenette, An illustrated guide to the flowers of Saudi Arabia, Flora publicationNo.1,Scorpion Publishing Ltd, Buckhurst hill, Essex, 1985,p. 162.
12. Bembde N. S,. Meshram P. V. Pati , M. K, Junaid Shaikh. The Preliminary Phytochemical Analysis of Ethanolic extract of Tylophora indica. Res. J. Pharmacognosy and Phytochem. 2020; 12(1):. 1-6. doi: 10.5958/0975-4385.2020.00001.1.
13. Madhuri M. Deshmukh, Chhaya S. Ambad, Nutan Kendre, Navnath G. Kashid. Biochemical Screening, Antibacterial and GC- MS ,Analysis of Ethanolic Extract of Hemidesmus indicus (L) R.Br. root. Res. J. Pharmacognosy and Phytochem. 2019; 11(2): 73-80. doi: 10.5958/0975-4385.2019.00014.1.
14. Evaluation of anti-inflammatory activities of isorhamnetin 3-O-α-L-(6’’-E-p-coumaroyl) rhamnoside isolated from Indigofera tinctoria” K Prabakaran, M Sathiyaseelan. Research J. Pharm. And Tech. 2020; 13 (5): 2187-2191. doi.10.5958/0974- 360X.2020.00393.5.
15. Chanchal Kumari, J. Deepalakshmi. Qualitative and GC-MS Analysis of Phytoconstituents of Parthenium hysterophorus Linn Res. J. Pharmacognosy and Phytochem. 2017; 9(2): 105-110. doi: 10.5958/0975-4385.2017.00019.X.
16. Suman T., Chakkaravarthi K, R. Elangomathavan. Phyto-chemical profiling of Cleistanthus collinus leaf extracts using GC-MS analysis. Research J. Pharm. and Tech. 2013; 6(11): 1173-1177. doi. 10.5958/0974-360X.
17. Vinod Kumar, Anket Sharma, Harpreet Kaur, Ashwani Kumar Thukral, Renu Bhardwaj. Phytochemical profiling of the leaves of Chenopodium and Polygonum using GC-MS. Research J. Pharm. and Tech. 2015; 8(12): 1629-1632. doi: 10.5958/0974-360X.2015.00292.9.
18. Ryszard A. Squalene: a natural antioxidant Eur J Lipid Sci Technol. 2009; 111: 411– 412. doi. 10.1002/ejlt.200900102.
19. Traber MG, Atkinson J. Vitamin E, antioxidant and nothing more. Free Radic Bio Med. 2007;43(1):4–15.doi. 10.1016/j.freeradbiomed.2007.03.024.
20. Suman T., Chakkaravarthi K, R. Elangomathavan. Phyto-chemical profiling of Cleistanthus collinus leaf extracts using GC-MS analysis. Research J. Pharm. and Tech. 2013; 6(11): 1173-1177.
21. Rao CV, Newmark HL, Reddy BS. Chemopreventive effect of squalene on colon cancer.Carcinogen. 1998; 19(2): 287- 297.doi. 10.1093/carcin/19.2.287.