Deepesh Parashar, Ajay Kumar Meena, Manoj Sharma
Deepesh Parashar1*, Ajay Kumar Meena2, Manoj Sharma1
1SOS in Pharmaceutical Sciences, Jiwaji University, Gwalior – 474011 (M.P).
2Regional Ayurveda Research Institute, CCRAS, Ministry of AYUSH, Gwalior - 474009 (MP).
Volume - 16,
Issue - 10,
Year - 2023
As a result of the modern lifestyle, which includes processed foods, exposure to a large number of toxins and a lack of exercise oxidative stress is induced, due to which free radical production happens continually in all cells as part of normal cellular activity. Excess free radical generation, which can come from a variety of endogenous or exogenous sources, is thought to have a role in the ageing process and the development of illnesses. High levels of reactive oxygen species, on the other hand, destroy lipids, proteins, and DNA by blocking, scavenging, or accelerating their breakdown. Consumer concerns about the safety of their health have prompted the food sector to look for natural alternatives to manufactured equivalents. So now antioxidant capabilities of medicinal plants are being utilised for their capacity to treat or prevent a variety of human illnesses, one of which appears to be oxidative stress. Flavonoids are a class of polyphenol secondary metabolite which serves as a natural antioxidant and is present in a variety of plants and diets. Antiviral, anti-inflammatory, cardioprotective, anti-diabetic, anti-cancer, anti-aging, and other bioactive qualities are known to exist in them. Flavonoids are the topic of this review, including their varieties and sources, structural characteristics, and therapeutic implications.
Cite this article:
Deepesh Parashar, Ajay Kumar Meena, Manoj Sharma. Flavonoids - A Review on Natural Antioxidants. Research Journal of Pharmacy and Technology 2023; 16(10):4952-8. doi: 10.52711/0974-360X.2023.00802
Deepesh Parashar, Ajay Kumar Meena, Manoj Sharma. Flavonoids - A Review on Natural Antioxidants. Research Journal of Pharmacy and Technology 2023; 16(10):4952-8. doi: 10.52711/0974-360X.2023.00802 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-10-72
1. Kurutas EB. The importance of antioxidants which play the role in cellular response against oxidative/nitrosative stress: current state. Nutrition Journal. 2015; 15(1):1-22. https://doi.org/10.1186/s12937-016-0186-5
2. Bright R, Raj PS, Amala K, Asokan N, Bel GL. Free Radical-A Sword with two Edges. 2021: 139-144. https://doi.org/10.5958/0974-4150.2021.00026.2
3. Finkel T, Holbrook NJ. Oxidative stress and aging: Catalase is a longevity determinant enzyme. Nature. 2000; 408: 239. https://doi.org/10.1038/35041687
4. Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB. Estrésoxidativo, inflamación y cáncer:¿cómoestánrelacionados?. Free Radical Biology and Medicine. 49(11):1603-16. https://doi.org/10.1016/j.freeradbiomed.2010.09.006
5. Aminjan HH, Abtahi SR, Hazrati E, Chamanara M, Jalili M, Paknejad B. Targeting of oxidative stress and inflammation through ROS/NF-kappaB pathway in phosphine-induced hepatotoxicity mitigation. Life Sciences. 2019; 232: 116607. https://doi.org/10.1016/j.lfs.2019.116607
6. Putta SK, Talapula BK. Detection of Free Radicals Using GC/MS Trapped By Tempo. Research Journal of Pharmacy and Technology. 2011; 4(9):1367-72.
7. Sahu P, Sahu K, Dubey RD, Chatterjee S, Chatterjee T. Herbal antioxidants: A review. Research Journal of Pharmacognosy and Phytochemistry. 2010; 2(6):434-6.
8. Sameer SJ, Vijay RS, Chandrakant SM. Daily consumption of antioxidants:-prevention of disease is better than cure. Asian Journal of Pharmaceutical Research. 2013;3(1):34-40.
9. Bright R, Raj PS, Amala K, Asokan N, Bel GL. Free Radical-A Sword with two Edges. 2021; 139-144. https://doi.org/10.5958/0974-4150.2021.00026.2
10. Selvakumar K, Madhan R, Srinivasan G, Baskar V. Antioxidant assays in pharmacological research. Asian Journal of Pharmacy and Technology. 2011; 1(4):99-103.
11. Saha D, Tamrakar A. Xenobiotics, oxidative stress, free radicals vs. antioxidants: dance of death to heaven’s life. Asian J Res Pharm Sci. 2011; 1(2):36-8.
12. Patel VK, Kpatel C, Patel HU, Patel CN. Vitamins, Minerals and Carotenoids as a Antioxidants. Asian Journal of Research in Chemistry. 2010; 3(2):255-60.
13. Hurrell RF. Influence of vegetable protein sources on trace element and mineral bioavailability. The Journal of nutrition. 2003; 133 (9):2973S-7S.https://doi.org/10.1093/jn/133.9.2973S
14. Middleton E. Effect of plant flavonoids on immune and inflammatory cell function. Flavonoids in the living system. 1998:175-82.https://doi.org/10.1007/978-1-4615-5335-9_13
15. Burak M, Imen Y. Flavonoids and their antioxidant properties. TurkiyeKlin Tip Bil Derg. 1999; 19: 296-304.
16. Castañeda-Ovando A, de Lourdes Pacheco-Hernández M, Páez-Hernández ME, Rodríguez JA, Galán-Vidal CA. Chemical studies of anthocyanins: A review. Food Chemistry. 2009; 113 (4): 859-71. https://doi.org/10.1016/j.foodchem.2008.09.001
17. Lee YK, Yuk DY, Lee JW, Lee SY, Ha TY, Oh KW, Yun YP, Hong JT. (−)-Epigallocatechin-3-gallate prevents lipopolysaccharide-induced elevation of beta-amyloid generation and memory deficiency. Brain research. 2009; 1250:164-74. https://doi.org/10.1016/j.brainres.2008.10.012
18. Chakraborty P, Kumar S, Dutta D, Gupta V. Role of antioxidants in common health diseases. Research Journal of Pharmacy and Technology. 2009; 2(2):238-44.
19. Wojdyło A, Oszmiański J, Czemerys R. Antioxidant activity and phenolic compounds in 32 selected herbs. Food chemistry. 2007; 105(3):940-9.https://doi.org/10.1016/j.foodchem.2007.04.038
20. Narayana KR, Reddy MS, Chaluvadi MR, Krishna DR. Bioflavonoids classification, pharmacological, biochemical effects and therapeutic potential. Indian Journal of Pharmacology. 2001; 33(1):2-16.
21. Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview. Journal of nutritional science. 2016; 5.https://doi.org/10.1017/jns.2016.41
22. Manach C, Scalbert A, Morand C, Rémésy C, Jiménez L. Polyphenols: food sources and bioavailability. The American Journal of Clinical Nutrition. 2004; 79(5):727-47. https://doi.org/10.1093/ajcn/79.5.727
23. Iwashina T. Flavonoid properties of five families newly incorporated into the order Caryophyllales. Bull NatlMus Nat Sci. 2013; 39:25-51.
24. Matthies A, Clavel T, Gütschow M, Engst W, Haller D, Blaut M, Braune A. Conversion of daidzein and genistein by an anaerobic bacterium newly isolated from the mouse intestine. Applied and environmental microbiology. 2008; 74(15):4847-52. https://doi.org/10.1128/aem.00555-08
25. Aoki T, Akashi T, Ayabe SI. Flavonoids of leguminous plants: structure, biological activity, and biosynthesis. Journal of Plant Research. 2000; 113(4):475-88. https://doi.org/10.1007/pl00013958
26. Dixon RA, Ferreira D. Genistein. Phytochemistry. 2002; 60(3):205-11.https://doi.org/10.1016/s0031-9422(02)00116-4
27. Szkudelska K, Nogowski L. Genistein—a dietary compound inducing hormonal and metabolic changes. The Journal of Steroid Biochemistry and Molecular Biology. 2007; 105(1-5):37-45.https://doi.org/10.1016/j.jsbmb.2007.01.005
28. Iinuma M, Tanaka T, Hamada K, Mizuno M, Asai F, Reher G, Kraus L. Revised structure of neoflavone in Coutareahexandra. Phytochemistry. 1987; 26(11):3096-7. https://doi.org/10.1016/s0031-9422(00)84609-9
29. Nishimuta S, Taki M, Takaishi S, Iijima Y, Akiyama T. Structures of 4-aryl-coumarin (neoflavone) dimers isolated from Pistaciachinensis BUNGE and their estrogen-like activity. Chemical and Pharmaceutical Bulletin. 2000; 48(4):505-8. https://doi.org/10.1248/cpb.48.505
30. Garazd MM, Garazd YL, Khilya VP. Neoflavones. 1. Natural distribution and spectral and biological properties. Chemistry of Natural Compounds. 2003; 39(1):54-121.https://doi.org/10.1023/a:1024140915526
31. Giusti MM, Wrolstad RE. Acylatedanthocyanins from edible sources and their applications in food systems. Biochemical Engineering Journal. 2003; 1 4(3):217-25. https://doi.org/10.1016/s1369-703x(02)00221-8
32. Hollman PH, Katan MB. Dietary flavonoids: intake, health effects and bioavailability. Food and Chemical Toxicology. 1999; 37(9-10): 937-42. https://doi.org/10.1016/s0278-6915(99)00079-4
33. Majewska M, Czeczot H. Flavonoids in prevention and therapy of diseases. Farm. Pol. 2009; 65: 369-77.
34. Ren W, Qiao Z, Wang H, Zhu L, Zhang L. Flavonoids: promising anticancer agents. Medicinal Research Reviews. 2003; 23(4):519-34.https://doi.org/10.1002/med.10033
35. Lopez M, Martınez F, Del Valle C, Orte C, Miro M. Analysis of phenolic constituents of biological interest in red wines by high-performance liquid chromatography. Journal of Chromatography A. 2001; 922(1-2): 359-63. https://doi.org/10.1016/s0021-9673(01)00913-x
36. Yamanishi T. Special issue on tea: Flavor of tea. Food Review Int.. 1995; 11:477-525.
37. Kreft S, Knapp M, Kreft I. Extraction of rutin from buckwheat (Fagopyrumesculentum Moench) seeds and determination by capillary electrophoresis. Journal of Agricultural and Food Chemistry. 1999; 47(11):4649-52. https://doi.org/10.1021/jf990186p
38. Stewart AJ, Bozonnet S, Mullen W, Jenkins GI, Lean ME, Crozier A. Occurrence of flavonols in tomatoes and tomato-based products. Journal of Agricultural and Food Chemistry. 2000; 48(7):2663-9.
39. Miyake Y, Shimoi K, Kumazawa S, Yamamoto K, Kinae N, Osawa T. Identification and antioxidant activity of flavonoid metabolites in plasma and urine of eriocitrin-treated rats. Journal of agricultural and food chemistry. 2000 Aug 21; 48(8):3217-24.https://doi.org/10.1021/jf990994g
40. Rouseff RL, Martin SF, Youtsey CO. Quantitative survey of narirutin, naringin, hesperidin, and neohesperidin in citrus. Journal of Agricultural and Food Chemistry. 1987; 35(6):1027-30. https://doi.org/10.1021/jf00078a040
41. Kaufman PB, Duke JA, Brielmann H, Boik J, Hoyt JE. A comparative survey of leguminous plants as sources of the isoflavones, genistein and daidzein: implications for human nutrition and health. The Journal of Alternative and Complementary Medicine. 1997; 3(1):7-12. https://doi.org/10.1089/acm.1997.3.7
42. Reinili K, Block G. Phytoestrogen content of foods–a compendium. Nutrition and Cancer. 1996; 26:123-48. https://doi.org/10.1080/01635589609514470
43. Formica JV, Regelson W. Review of the biology of quercetin and related bioflavonoids. Food and Chemical Toxicology. 1995; 33(12):1061-80. https://doi.org/10.1016/0278-6915(95)00077-1
44. Hertog MG, Feskens EJ, Kromhout D, Hollman PC, Katan MB. Dietary antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. The Lancet. 1993; 342(8878):1007-11.https://doi.org/10.1016/0140-6736(93)92876-U
45. Ferrandiz ML, Alcaraz M. Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids. Agents and Actions. 1991; 32(3):283-8. https://doi.org/10.1007/BF01980887
46. Laughton MJ, Evans PJ, Moroney MA, Hoult JR, Halliwell B. Inhibition of mammalian 5-lipoxygenase and cyclo-oxygenase by flavonoids and phenolic dietary additives: relationship to antioxidant activity and to iron ion-reducing ability. Biochemical pharmacology. 1991; 42(9):1673-81.https://doi.org/10.1016/0006-2952(91)90501-u
47. Robak J, Gryglewski RJ. Bioactivity of flavonoids. Polish Journal of Pharmacology. 1996; 48(6):555-64.
48. Kim HP, Mani I, Iversen L, Ziboh VA. Effects of naturally-occurring flavonoids and biflavonoids on epidermal cyclooxygenase and lipoxygenase from guinea-pigs. Prostaglandins, Leukotrienes and Essential Fatty Acids. 1998; 58(1):17-24.https://doi.org/10.1016/S0952-3278(98)90125-9
49. Tapas A, Sakarkar D, Kakde R. The chemistry and biology of bioflavonoids. Research Journal of Pharmacy and Technology. 2008; 1(3):132-43.
50. Loft S, Poulsen HE. Cancer risk and oxidative DNA damage in man. Journal of molecular medicine. 1996 Jun; 74(6):297-312.https://doi.org/10.1007/BF00207507
51. Arya B, Krishnaveni K, Sambathkumar R. Review on Antioxidant Supplements use in Cancer Chemotherapy. Research Journal of Pharmacology and Pharmacodynamics. 2020; 12(1):21-4. https://doi.org/10.5958/2321-5836.2020.00005.1
52. De Stefani E, Boffetta P, Deneo-Pellegrini H, Mendilaharsu M, Carzoglio JC, Ronco A, Olivera L. Dietary antioxidants and lung cancer risk: a case-control study in Uruguay. Nutrition and Cancer. 1999; 34(1):100-10. https://doi.org/10.1207/S15327914NC340114
53. Fotsis T, Pepper MS, Aktas E, Breit S, Rasku S, Adlercreutz H, Wähälä K, Montesano R, Schweigerer L. Flavonoids, dietary-derived inhibitors of cell proliferation and in vitro angiogenesis. Cancer Research. 1997; 57(14):2916-21.
54. Fan TP, Jagger R, Bicknell R. Controlling the vasculature: angiogenesis, anti-angiogenesis and vascular targeting of gene therapy. Trends in Pharmacological Sciences. 1995; 16(2):57-66. https://doi.org/10.1016/S0165-6147(00)88979-8
55. Paper DH. Natural products as angiogenesis inhibitors. Plantamedica. 1998; 64(8):686-95.https://doi.org/10.1055/s-2006-957559
56. Lou FQ, Zhang MF, Zhang XG, Liu JM, Yuan WL. A STUDY ON Tea-Pigmentin Prevention of Atherosclerosis. Chinese Medical Journal. 1989; 102(08):579-83. https://doi/abs/10.5555/cmj.0366-6999.102.08.p579.01
57. Osman HE, Maalej N, Shanmuganayagam D, Folts JD. Grape juice but not orange or grapefruit juice inhibits platelet activity in dogs and monkeys (Macacafasciularis). The Journal of Nutrition. 1998; 128(12):2307-12. https://doi.org/10.1093/jn/128.12.2307
58. Gryglewski RJ, Korbut R, Robak J, Świȩs J. On the mechanism of antithrombotic action of flavonoids. Biochemical Pharmacology. 1987; 36(3):317-22.https://doi.org/10.1016/0006-2952(87)90288-7
59. Hegarty V M, May HM, Khaw KT. Tea drinking and bone mineral density in older women. The American Journal of Clinical Nutrition. 2000; 71(4):1003-7. https://doi.org/10.1093/ajcn/71.4.1003
60. Wang HK, Xia Y, Yang ZY, Morris Natschke SL, Lee KH. Recent advances in the discovery and development of flavonoids and their analogues as antitumor and anti-HIV agents. Flavonoids in the Living System. 1998:191-225.https://doi.org/10.1007/978-1-4615-5335-9_15
61. Kaul TN. Middleton E Jr, Ogra PL. Antiviral effect of flavonoids on human viruses. J Med Virol. 1985; 15: 71-9.https://doi.org/10.1002/jmv.1890150110
62. Bae EA, Han MJ, Lee M, Kim DH. In vitro inhibitory effect of some flavonoids on rotavirus infectivity. Biological and Pharmaceutical Bulletin. 2000; 23(9):1122-4. https://doi.org/10.1248/bpb.23.1122