Author(s):
Naveen Kumar, Pramod Kumar, Satheesha Nayak B, Melissa Glenda Lewis, Ashwini Aithal P, Ravi Bhaskar
Email(s):
ashwini.anat@gmail.com , ashwini.aithal@manipal.edu
DOI:
10.52711/0974-360X.2023.00737 
Address:
Naveen Kumar1, Pramod Kumar2, Satheesha Nayak B3, Melissa Glenda Lewis4, Ashwini Aithal P3, Ravi Bhaskar5
1Department of Anatomy, Ras Al Khaimah College of Medical Sciences, RAK Medical and Health Sciences University, Ras Al Khaimah, UAE (Present). Former Faculty of Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, India.
2Consultant Plastic Surgeon, King Fahad Central Hospital, Jazan, Saudi Arabia.
3Division of Anatomy, Department of Basic Medical Sciences, Manipal Academy of Higher Education, Manipal, India.
4Indian Institute of Public Health, Shillong, Meghalaya, India.
5Department of Anatomy, Sapthagiri Institute of Medical Sciences and Research Centre, Bengaluru, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 10,
Year - 2023
ABSTRACT:
Background: The collagen and the elastic fiber content of the dermis is known to show the asymmetric distribution across the planes of the body region. During the period of limb development, the upper and lower limbs rotate 90 degrees laterally and medially respectively. Objectives: The study aims to check if the limb bud rotation during embryonic development favors the unequal distribution of the dermal connective tissue fiber content distribution. Methods: A total of 240 skin samples from the forearm and thigh regions of adult human cadavers were collected in horizontal and vertical directions from the anatomical and oblique planes. The tissues were processed with tissue-quant analysis. The data were analyzed statistically using SPSS. Results: There were no significant differences in the pattern of distribution of the collagen and elastic fiber contents in the tissues of horizontal and vertical directions from the two planes of forearm and thigh regions. However significant Spearman's correlation was observed in both elements in the thigh region but only the collagen content in the forearm region. Conclusion: The pattern of distribution of connective tissue fibers in the dermis is regulated by the mechanical communications between the cells and their extracellular matrices. Hence, the significant role of embryologic limb rotation in the event of unequal distribution of dermal collagen and elastic fibers in the limb region is to be ruled out.
Cite this article:
Naveen Kumar, Pramod Kumar, Satheesha Nayak B, Melissa Glenda Lewis, Ashwini Aithal P, Ravi Bhaskar. Does the Embryologic Limb Rotation Modify the Distribution of Dermal Collagen and Elastic Fibers in Different Planes of Human Extremities?. Research Journal of Pharmacy and Technology 2023; 16(10):4525-9. doi: 10.52711/0974-360X.2023.00737
Cite(Electronic):
Naveen Kumar, Pramod Kumar, Satheesha Nayak B, Melissa Glenda Lewis, Ashwini Aithal P, Ravi Bhaskar. Does the Embryologic Limb Rotation Modify the Distribution of Dermal Collagen and Elastic Fibers in Different Planes of Human Extremities?. Research Journal of Pharmacy and Technology 2023; 16(10):4525-9. doi: 10.52711/0974-360X.2023.00737 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-10-7
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