Prafulla Tathe, Vaibhav P. Uplanchiwar, Sachin M. Hiradeve, Sushil Yadaorao Raut, Gayatri Katole, Mayuri Deshmukh, Namrata Mane, Vijendra B. Fulzele, Mohd. Hashim Mansoori
Prafulla Tathe1*, Vaibhav P. Uplanchiwar2, Sachin M. Hiradeve2, Sushil Yadaorao Raut4, Gayatri Katole2, Mayuri Deshmukh2, Namrata Mane2, Vijendra B. Fulzele3, Mohd. Hashim Mansoori3
1Research Scholar, Shri Jagdishprasad Jhabarmal Tibrewala University, Jhunjhunu, Churu Rd, Vidyanagari, Churela - 333001, Rajasthan, India.
2Nagpur College of Pharmacy, Wanadongari, Hingna Road, Nagpur - 441110, Maharashtra, India.
3School of Pharmacy, G H Raisoni University, G H Raisoni Nagar, Saikheda, Dist: Chhindwara - 480106, Madhya Pradesh, India.
4Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research,
Sant Tukaram Nagar, Pimpri, Pune, Maharashtra, India.
Volume - 16,
Issue - 10,
Year - 2023
While dealing with the herbal drugs for various chaoses, flavonoids and saponin established their position and hepatoprotection is fine example among all health related issues. So, the study was executed taking into considerations of edible herbal constituents to check the potency of fruits extract of Sesbania grandiflora (FESG) on thioacetamide induced hepatotoxicity in experimental animals. In experimentation, the petroleum ether (PE) extracts at 100, 200 and 400mg/kg/p.o was fed to rats before intoxicated with thioacetamide (100 mg/kg). To check the efficacy of plant material, the diverse factors were assessed like SGOT, SGPT, SALP, bilirubin, protein, cholesterol, albumin and triglyceride and to confirm the study, liver histopathology was also determined. The obtained result parameters authenticated the strength of plant material via assessed factors with endorsement by histopathological study. The shielding outcome of this extract was due to the occurrence of phenol, flavonoids, and various antioxidants and due to existence of quercetin in it.
Cite this article:
Prafulla Tathe, Vaibhav P. Uplanchiwar, Sachin M. Hiradeve, Sushil Yadaorao Raut, Gayatri Katole, Mayuri Deshmukh, Namrata Mane, Vijendra B. Fulzele, Mohd. Hashim Mansoori. Assessment of Antihepatotoxic potential of Sesbania grandiflora fruits extract against Organosulfur compound- thioacetamide induced hepatopathy in experimental rodents. Research Journal of Pharmacy and Technology 2023; 16(10):4929-4. doi: 10.52711/0974-360X.2023.00799
Prafulla Tathe, Vaibhav P. Uplanchiwar, Sachin M. Hiradeve, Sushil Yadaorao Raut, Gayatri Katole, Mayuri Deshmukh, Namrata Mane, Vijendra B. Fulzele, Mohd. Hashim Mansoori. Assessment of Antihepatotoxic potential of Sesbania grandiflora fruits extract against Organosulfur compound- thioacetamide induced hepatopathy in experimental rodents. Research Journal of Pharmacy and Technology 2023; 16(10):4929-4. doi: 10.52711/0974-360X.2023.00799 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-10-69
1. Kasture VS, Deshmukh VK, Chopde CT. Anxiolytic and anticonvulsive activity of Sesbania grandiflora leaves in experimental animals. Phytotherapy Research. 2002; 16:455-60.
2. Marappan S, Manickam K, Suganya DP. Bioactive compounds in Sesbania grandiflora flower and its antioxidant and antimicrobial activity. Journal of pharmacy Research. 2012; 5:390-3.
3. Doddola S, Pasupulati H, Koganti B. Evaluation of Sesbania grandiflora for antiurolithiatic and antioxidant properties. Journal of Natural Medicine. 2008; 62:300–07. https://doi.org/10.1007/s11418-008-0235-2.
4. Pari L. Protective Effect of Sesbania grandiflora against erythromycin estolate-induced hepatotoxicity. Therapies. 2003; 58(5):439-43.
5. Himgauri V et al. Study of Antiulcer Activity of Leaves of Sesbania grandiflora Linn. (Fabaceae). Research Journal of Pharmacognosy and Phytochemistry. 2012; 4(6): 322-325.
6. Krasaekoopt W, Kongkarnchanatip A. Anti-microbial properties of Thai traditional flower vegetable extracts. AU Journal of Technology. 2005; 9(2):71-4
7. Tamboli SA, Pal SC, Kasture SB. Analgesic and antipyretic activity of flowers of Sesbania grandiflora: Indian Drugs. 2000; 37: 95- 8.
8. Saravanakumar A, et al. Hypolipidemic activity of Sesbania grandiflora in triton WR 1339 induced hyperlipidaemic rats. International Journal of Phytomedicine. 2010; 2:52 8.
9. Ramesh T, et al. Cardio protective effects of Sesbania grandiflora in cigarette smoke-exposed rats. Journal of Cardiovascular Pharmacololgy. 2008; 52(4): 338-43. doi:10.1097/FJC.0b013e3181888383
10. Veerapur VP, Desai PP, Vijayakumar S. Pharmacognostic and Preliminary Phytochemical Screening of Sesbania grandiflora root. Research Journal of Pharmacognosy and Phytochemistry. 2018; 10(4): 285-290.
11. Sahu P, et al. Herbal Antioxidants: A Review. Research Journal of Pharmacognosy and Phytochemistry. 2010; 2(6): 427-434.
12. Ahsan R, et al. Hepatoprotective activity of methanol extract of some medicinal plants against carbon tetrachloride induced hepatotoxicity in albino rats. European Journal of Scientific Research. 2009; 37: 302-10.
13. OECD 2001-Gudeline on acute oral toxicity (AOT) Environmental health and safety monograph series on testing and adjustment number 425.
14. Gupta M, et al. Antioxidant and hepatoprotective effects of Bauhinia racemosa against paracetamol and carbon tetrachloride induced liver damage in rats. Iranian Journal of Pharmacology & Therapeutics. 2004; 3(1): 1-12.
15. Thamarai Selvi P et al. Antistress activity of aqueous extract of leaves of Centella asiatica. Linn by in- vivo methods. Asian Journal of research in pharmaceutical sciences. 2012; 2(3):91-94.
16. Reitman S, Frankle S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology. 1957; 28:56-63. https://doi.org/10.1093/ajcp/28.1.56
17. King J. The trasferases-alanine and aspartate transaminases. In: D. Van (ed). Practical Clinical Enzymology, Nostrand Company Ltd, London (1965):121-38
18. Malloy HT, Evelyn KA. The determination of Bilirubin with the photometric colorimeter: Journal of Biological Chemistry. 1937; 19: 481.
19. Jyothi Y, et al. Effect of hexane extract of Coleus forskohlii on chemically induced liver damage. Research Journal of Pharmacology and Pharmacodynamics. 2010; 2(6): 380-383.
20. Vadivelan R, Umasankar P, Dipanjan Mandal, Shanish A, Dhanabal SP, Elango K. Oxidative Stress Induced Diabetic Nephropathy. Research Journal of Pharmacology and Pharmacodynamics. 2010; 2(5): 321-323.
21. S. Manokaran, V.S. Saravanan, Y. Bhargavi. Hepatoprotective Activity of Prunus persica Peaches against Paracetamol Induced Hepatotoxicity. Research Journal of Pharmacognosy and Phytochemistry 2011; 3(2): 75-76
22. Li S, et al. The Role of Oxidative Stress and Antioxidants in Liver Diseases: International Journal of Molecular Sciences. 2015; 16(11): 26087–124. https://doi.org/10.3390/ijms161125942.
23. Fernánde CD, Sanz N, Cascales M. Changes in glucose-6-phosphate dehydrogenase and malic enzyme gene expression in acute hepatic injury induced by thioacetamide. Biochemical Pharmacology. 1996; 51(9):1159-63.
24. Sawarkar DJ, et al. Hepatoprotective activity of ethanolic and ethyl acetate extract of Ziziphus mauriatiana on liver damage caused by paracetamol in rats. Research Journal of Pharmacognosy and Phytochemistry. 2009; 1(3): 194-197.
25. Pradeep Kumar Samal. Hepatoprotective activity of Tamarindus indica on liver damage caused by thioacetamide. Research Journal of Pharmacognosy and Phytochemistry. 2013; 5(3): 123-126.
26. Rajesh MG, Latha MS. Hepatoprotective activity of Glycyrrhiza glabra Linn on experimental liver damage in albino rats. Research Journal of Pharmacognosy and Phytochemistry 2010; 2(4): 313-316.
27. Pyo Y, et al. Antioxidant activity and phenolic compounds of Swiss chard (Beta vulgaris subspecies cycla) extracts: Food Chemistry. 2004; 85:19-26. doi: 10.1016/S0308-8146(03)00294-2
28. Umesh B. Telrandhe, Anuj Modi, Vaibhav Uplanchiwar, Avinash Gahane, S. Hemalatha, D.V.Goswami. Hepatoprotective and Antioxidant activity of Root of Cadaba farinosa, Forsk. Against Carbon Tetra Chloride induced Hepatotoxicity in Rats. Journal of Pharmacy Research 2010, 3(6).
29. B. Venkatesh, Bheemachari, Vaibhav Uplanchiwar, Anuj Modi, Avinash Gahane, S.K.Jain, Siddharth Tiwari. “Hepatoprotective Effect of L-35-A Polyherbal Formulation”. Pharmacologyonline. 2010; 3: 431-438.