Author(s):
Yatish Byndoor, Tamilisetti Vidya Sagar, Raju H Patil, Dakkumalla Veeraiah
Email(s):
dr.yati1988@gmail.com , veerudakkumalla@gmail.com
DOI:
10.52711/0974-360X.2023.00798 
Address:
Yatish Byndoor1, Tamilisetti Vidya Sagar2, Raju H Patil3, Dakkumalla Veeraiah4
1Associate Professor, Department of Pharmacology, Apollo Institute of Medical Sciences and Research, Chittoor, AP, India.
2Associate Professor, Department of Pharmacology, GSL Medical College, Rajahmundry, India.
3Associate Professor, Department of Community Medicine, Varun Arjun Medical College and Rohilkhand Hospital, Banthra, UP.
4Assistant Professor, Department of Pharmacology, Rangaraya Medical College, Kakinada, AP.
*Corresponding Author
Published In:
Volume - 16,
Issue - 10,
Year - 2023
ABSTRACT:
Objective: To compare vitamin D with placebo in patients with pulmonary tuberculosis in terms of clinical improvement and sputum conversion. Materials And Methods: This is a prospective randomized, double blind, placebo controlled comparative study conducted for a period of 12 weeks in a tertiary care centre in south India. Total Subjects were 60 new cases of pulmonary tuberculosis who are getting TB treatment initiation, Subjects were randomly allocated into two groups, group A and group B comprising of 30 patients in each group. Group A received vitamin D and group B received placebo. Dosage of vitamin D was 0.25mg/day, given in initial six weeks of antituberculosis drug therapy. Serum level of 25-hydroxyvitamin D was measured at time of diagnosis and at 8 weeks of anti-tuberculous therapy. Measurements of haemoglobin, leukocyte count and serum calcium were done at beginning and repeated at 6th, 8th and 12 weeks. Acid fast bacilli were examined at beginning and on 6th, 8thand 12 weeks. Primary outcome was evaluation of conversion time of sputum smear; secondary outcome was clinical improvement as assessed by TB score. Results: There is no significant difference in mean values of age, haemoglobin level, calcium level,serum Vitamin D, TB score and total lymphocyte count in both groups at start of study.There was no statistical difference in serum calcium level, haemoglobin level and total lymphocyte level at end of study. Mean serum vitamin D level at 8th week of treatment was 27.83±7.09ng/dl in group A and 18.83±2.27 in group B, there was statistically significant difference between two groups. Sixth week sputum conversion in 30 subjects of vitamin D group is 100% and in placebo group, it is 76.7%, which was statistically significant. Conclusion: Supplementary vitamin D when added to first line anti-tuberculous drugs results in shorter conversion time and less severe TB clinical manifestation without any manifestations of hypercalcemia. Therefore, it is recommended to add vitamin D as supplementary treatment to first-line anti-tuberculous drugs in treatment course of active pulmonary TB.
Cite this article:
Yatish Byndoor, Tamilisetti Vidya Sagar, Raju H Patil, Dakkumalla Veeraiah. Vitamin D as Supplementary Treatment for Newly Diagnosed Pulmonary Tuberculosis patients. Research Journal of Pharmacy and Technology 2023; 16(10):4924-8. doi: 10.52711/0974-360X.2023.00798
Cite(Electronic):
Yatish Byndoor, Tamilisetti Vidya Sagar, Raju H Patil, Dakkumalla Veeraiah. Vitamin D as Supplementary Treatment for Newly Diagnosed Pulmonary Tuberculosis patients. Research Journal of Pharmacy and Technology 2023; 16(10):4924-8. doi: 10.52711/0974-360X.2023.00798 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-10-68
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