Author(s):
MM. Riyaniarti Estri Wuryandari, Ninis Yuliati, Ekawati sutikno, Hartati Tuna, Nita Damayanti, Muhaimin Rifa’i, Mochammad Fitri Atho’illah, Rizky Dzariyani Laili
Email(s):
mm.riyaniarti@iik.ac.id
DOI:
10.52711/0974-360X.2023.00774 
Address:
MM. Riyaniarti Estri Wuryandari1*, Ninis Yuliati1, Ekawati sutikno2, Hartati Tuna3, Nita Damayanti4, Muhaimin Rifa’i5, Mochammad Fitri Atho’illah5, Rizky Dzariyani Laili6
1Department of Pharmacy, Faculty of Pharmacy, Institut Ilmu Kesehatan Bhakti Wiyata,
64114, Kediri, East Java, Indonesia.
2Department of D3 Medical Laboratory Technology, Faculty of Tecnology and Health Management,
Institut Ilmu Kesehatan Bhakti Wiyata, 64114, Kediri, East Java, Indonesia.
3Department of D4 Medical Laboratory Technology, Faculty of Tecnology and Health Management,
Institut Ilmu Kesehatan Bhakti Wiyata, 64114, Kediri, East Java, Indonesia.
4Departement of Dentistry, Faculty Dental, Institut Ilmu Kesehatan Bhakti Wiyata, 64114,
Kediri, East Java Indonesia.
5Department of Biology, Faculty of Mathematics and Natural Sciences, Brawijaya University, 65145,
Malang, East Java, Indonesia
6Department of Nutrition, Sekolah Tinggi Ilmu Kesehatan Hang Tuah Surabaya, 60244,
Surabaya, East Java, I
Published In:
Volume - 16,
Issue - 10,
Year - 2023
ABSTRACT:
Interleukin-21(IL-21) and interleukin-22(IL-22) expressions in the substantial intestine increase when inflammation occurs. They can also induce the production of pro-inflammatory cytokines and Matrix Metallo Proteinases (MMP) in subepithelial fibroblasts. To evaluate at IL-21 and IL-22 expressions in BALB/c mice after administering red M. oleifera leaf fermented extracts exposed to Salmonella typhi. The expression of IL-21 and IL-22 were evaluated for immunomodulatory effect was analyzed by flowcytometer. Data were analyzed by one-way ANOVA and continued with the Tukey test (p<0.05). The results showed that the fermented extract of red M. oleifera leaves could act as an immunosuppressor characterized by decreased levels of IL-21 and IL-22 both on CD4 T and CD8 T cells in mice injected with Salmonella typhi ranging from 14 mg/Kg BW to 42 mg/Kg BW and Pyrex analysis explains that the cathecin compound has the same active side as 8MR in forming bonds with MMP-9. The results of this study provide is the fermented extract of red M. oleifera leaves decreasing the expression of CD4+IL21+, CD8+IL21+ and CD4+IL22+, CD8+IL22+ through inhibition of MMP-9
Cite this article:
MM. Riyaniarti Estri Wuryandari, Ninis Yuliati, Ekawati sutikno, Hartati Tuna, Nita Damayanti, Muhaimin Rifa’i, Mochammad Fitri Atho’illah, Rizky Dzariyani Laili. Immunomodulatory effect of Red Moringa oleifera Leaves Fermentation Extract on Il-21 And Il-22 Expressions in Balb/C Mice Exposed to Salmonella typhi. Research Journal of Pharmacy and Technology 2023; 16(10):4774-0. doi: 10.52711/0974-360X.2023.00774
Cite(Electronic):
MM. Riyaniarti Estri Wuryandari, Ninis Yuliati, Ekawati sutikno, Hartati Tuna, Nita Damayanti, Muhaimin Rifa’i, Mochammad Fitri Atho’illah, Rizky Dzariyani Laili. Immunomodulatory effect of Red Moringa oleifera Leaves Fermentation Extract on Il-21 And Il-22 Expressions in Balb/C Mice Exposed to Salmonella typhi. Research Journal of Pharmacy and Technology 2023; 16(10):4774-0. doi: 10.52711/0974-360X.2023.00774 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-10-44
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