Tanushree C., Rajesh Verma, Jaya Sharma, Pankaj Sharma
email@example.com , firstname.lastname@example.org , email@example.com , sharmapankaj_73@@yahoo.co.in
Tanushree C., Rajesh Verma, Jaya Sharma, Pankaj Sharma
Al-Ameen College of Pharmacy, Bangalore - 27 2. Apex University, Jaipur.
Volume - 16,
Issue - 10,
Year - 2023
Clindamycin is a semisynthetic lincosamide antibiotic useful for the treatment of a number of bacterial infections. Clindamycin Phosphate (CP) belongs to BCS class III that is high solubility, low permeability with a topical bioavailability of 4-5%. In the present study permeability is enhanced by targeted drug release formulation of topical Clindamycin Phosphate nanosponges were prepared by Emulsion solvent diffusion method using Ethyl cellulose as release retardant polymer and PVA as surfactant or emulsifier. Nanosponges were prepared by emulsion solvent diffusion method by changing drug polymer ratio (1:0.05, 1:0.1, 1:0.15) and process parameters were optimized using 32 full factorial central design. CP nanosponges were then incorporated into a hydrogel prepared using Carbopol 934. The drug loaded nanosponges were evaluated for physical appearance, drug content, entrapment efficiency, and particle size. Characterization of CP nanosponges were done by and Scanning Electron Microscopy for the formulation. In-vitro release study indicated that the release of CP varied according to the concentration of matrix forming polymer. The best standardized formulation G5 and G6 were further evaluated for microbiological studies. Microbial studies were done using staphylococcus aureus as the strain organism and the activity of the gel against the organism was evaluated by measuring the zone of inhibition. It was also found to be stable for 2 months during its stability studies. Thus, it was concluded that CP can be formulated as Nanosponge hydrogel that can release the drug up to 24hrs with increased permeability and targeted release. Therefore, Topical Clindamycin Phosphate nanosponges prepared are promising drug delivery for topical application as being more useful than conventional formulation therapy.
Cite this article:
Tanushree C., Rajesh Verma, Jaya Sharma, Pankaj Sharma. Alternative Therapeutic Nanosponge approach for Treatment of Flesh-Eating Disease- Necrotizing Fasciitis. Research Journal of Pharmacy and Technology 2023; 16(10):4626-4. doi: 10.52711/0974-360X.2023.00753
Tanushree C., Rajesh Verma, Jaya Sharma, Pankaj Sharma. Alternative Therapeutic Nanosponge approach for Treatment of Flesh-Eating Disease- Necrotizing Fasciitis. Research Journal of Pharmacy and Technology 2023; 16(10):4626-4. doi: 10.52711/0974-360X.2023.00753 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-10-23
1. Sadhasivam J, Sugumaran A, Damodharan N. Nano Sponges: A Potential Drug Delivery Approach. Research J. Pharm. and Tech. 2020; 13(7): 3442-3448. doi: 10.5958/0974-360X.2020.00611.3.
2. Praveen. K, Balamurugan. K. Targeted Drug Delivery through Nanosponges and its Approach. Research J. Pharm. and Tech. 2020; 13(7): 3524-3529.doi: 10.5958/0974-360X.2020.00624.1
3. Rajam RP, Muthukumar KR. An Updated Comprehensive Review on Nanosponges – Novel Emerging Drug Delivery System. Research J Pharm. and Tech. 2021; 14(8):4476-4.
4. Prabhu PP, Mehta C H, Nayak. Nanosponges-Revolutionary Approach: A Review. Research J. Pharm. and Tech. 2020; 13(7): 3536-3544.doi 10.5958/0974-360X.2020.00626.5
5. Ahad HA, Chintaginjala H, Rahamathulla S, Rupasree A, Kumar AS, Pallavi BP. Pathfinder Nanosponges for Drug Targeting by Factorial Design: A Glance Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2021; 13(4):341-4.doi: 10.52711/0975-4377.2021.00055
6. Davoudian P. and Flint N. Necrotizing fasciitis. Continuing Education in Anaesthesia Critical Care and Pain (2012);12(5), pp.245-250. doi: 10.1093/bjaceaccp/mks033.
7. Nitish, Jeganath S, Fathelrahman KA. A Review on Nanosponges – A Promising Novel Drug Delivery System. Research J. Pharm. and Tech. 2021; 14(1):501-505.doi:10.5958/0974-360X.2021.00091.3
8. Satpathy TK, Chaubey N, Chandan Kumar Brahma, Mittal Maheshwari. Formulation and Evaluation of Lamotrigine Loaded Nanosponges. Research J Pharm. and Tech. 2022; 15(1):229-5. doi:10.52711/0974-360X.2022.00038
9. Farsana P, Sivakumar R, Haribabu Y. Hydrogel based Nanosponges drug delivery for topical applications – A updated review. Research J. Pharm. and Tech. 2021; 14(1):527-530.doi: 10.5958/0974-360X.2021.00096.2
10. Ranjitha R, Elango K, Damayanthi DR, Niyaz SH U. Formulation and Evaluation of Lovastatin Loaded Nanosponges for the treatment of Hyperlipidemia. Research J Pharm and Tech. 2021; 14(11):5653-0. doi: 10.52711/0974-360X.2021.00983
11. En.wikipedia.org. (2019). Necrotizing fasciitis. [online] Available at: https://en.wikipedia.org/wiki/Necrotizing_fasciitis [Accessed 14 Apr. 2019].
12. Vishwakarma, A. Review On Nanosponges: A Beneficiation For Novel Drug Delivery. Int.J. PharmTech Res (2014); 6(1), pp.11-20.
13. Gedam SS, Basarkar GD. Formulation, Design and In-Vitro Characterization of Clopidogrel Bisulphate Nanosponge Tablets for Oral Administration. Research Journal of Pharmacy and Technology. 2021; 14(4):2069-5.doi:10.52711/0974-360X.2021.00367
14. Harsha G, Shaik NB, PK Lakshmi and Latha K. Formulation and Evaluation of Sertaconazole nitrate loaded Nanosponges for topical application. Research J. Pharm. and Tech. 2021; 14(2):895-902.doi:10.5958/0974-360X.2021.00159.1
15. Mitragotri S, D. Designer Biomaterials for Nanomedicine. Adv. Funct. Mater. (2009); 19(24), pp.3843-3854.doi1:https://doi.org/10.1002/adfm.200901538
16. Azadi A, Hamidi M, Pedram R. Hydrogel nanoparticles in drug delivery. Adv. Drug Deliv. Rev. (2008); 60(15), pp.1638-1649. doi:10.1016/j.addr.2008.08.002
17. Sajja HK, East MP, MaoH, Wang AY, Nie S,and Yang L. Development of multifunctional nanoparticles for targetted drug delivery and noninvasive imaging of therapeutic effect. Curr. Drug Discov. Technol. (2009); 6(1), pp.43-51.doi:10.2174/157016309787581066.
18. Trotta F, S. Formulation of beta cyclodextrin based nanosponges of itraconazole (2007); J Incl Phenom Macro Chem, 5(7), pp.89-94.doi: https://doi.org/10.1080/17425247.2019.1591365.
19. Kumari P, Mishra SK.. A comprehensive review on novel microsponges drug delivery approach. Asian J Pharm Clin Res (2016);9(1), pp.25-30. doi:10.9790/3008-1505030113.
20. Emedicine.medscape.com. (2019). Necrotizing Fasciitis: Background, Pathophysiology, Etiology. [online] Available at: https://emedicine.medscape.com/article/2051157-overview [Accessed 14 Apr. 2019].
21. NORD (National Organization for Rare Disorders). (2019). Necrotizing Fasciitis - NORD (National Organization for Rare Disorders). [online] Available at: https://rarediseases.org/rare-diseases/necrotizing-fasciitis/ [Accessed 14 Apr. 2019].
22. Hakkarainen, T., Kopari, N., Pham, T. and Evans, H. Necrotizing soft tissue infections: Review and current concepts in treatment, systems of care, and outcomes. Current Problems in Surgery. 2014; 51(8): 344-362.doi 10.1067/j.cpsurg.2014.06.001
23. Shoaib Q. Development and evaluation of scaffold-based nanosponge formulation for controlled drug delivery of naproxen and ibuprofen. Trop. J. Pharm. Res 2018;17(18):1465-1474.doi: 10.4314/tjpr.v17i8.2
24. Jainey P. James, Sneh Priya, Divya Jyothi. Effect of PLGA polymer on Antimicrobial Activity and the Release Studies of Nanoparticle Hydrogel Containing Mimosa pudica Extract. Research J. Pharm. and Tech. 2018; 11(7): 2876-2880.doi: 10.5958/0974-360X.2018.00530.9