Author(s): Prakash M. Somade, Pramod Anil Patil, Suraj N. Mali, Pratibha S. Gavarkar, Rohan Sharadanand Phatak, Rajashree S. Chavan, Atul R. Chopade

Email(s): prithvirajpatil87@gmail.com

DOI: 10.52711/0974-360X.2023.00006   

Address: Prakash M. Somade1, Pramod Anil Patil2, Suraj N. Mali3, Pratibha S. Gavarkar4, Rohan Sharadanand Phatak1, Rajashree S. Chavan5, Atul R. Chopade2
1Krishna Institute of Medical Science "Deemed to be University", Karad - 415539, Maharashtra.
2Rajarambapu College of Pharmacy, Kasegaon, District – Sangli, Maharashtra, 415404. India.
3Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology Mesra, Ranchi, (Jharkhand) 835215 India.
4Dept. of Pharmaceutical Chemistry, Anandi Pharmacy College, Kalambe tarf Kale, Tal - Karveer, Dist- Kolhapur 416205.
5Principal, Seth Govind Raghunath Sable College of Pharmacy, Saswad, Dist - Pune, Tal - Purandar 412301.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2023


ABSTRACT:
Main aim of study is to investigate the Rubiadin effects in mice model of chronic inflammation and pain. Complete Freund’s adjuvant (CFA) inflammatory model was used for investigation of chronic hypersensitivity. Prior CFA inflammation, Von Frey filaments and acetone induced cold sensitivity test was used to evaluate hypersensitivity, respectively. The paw edema was measured using digital plethysmometer. Intraperitoneally administered Rubiadin (100 and 200mg/kg) prior testing reduced CFA induced mechanical hypersensitivity. Rubiadin reduces evoked acetone cold hypersensitivity. Compared with vehicle, Rubiadin reduces paw edema too. Rubiadin reduced mechanical hypersensitivity significantly when administered two times a day from first to fifth day and from ninth to tenth day. In conclusion study revealed Rubiadin anti-nociceptive activity in chronic pain and also might be potential for effective management of pain.


Cite this article:
Prakash M. Somade, Pramod Anil Patil, Suraj N. Mali, Pratibha S. Gavarkar, Rohan Sharadanand Phatak, Rajashree S. Chavan, Atul R. Chopade. Antinociceptive Investigations of Rubiadin in Chronic pain induced by Freund’s adjuvant in mice. Research Journal of Pharmacy and Technology 2023; 16(1):31-4. doi: 10.52711/0974-360X.2023.00006

Cite(Electronic):
Prakash M. Somade, Pramod Anil Patil, Suraj N. Mali, Pratibha S. Gavarkar, Rohan Sharadanand Phatak, Rajashree S. Chavan, Atul R. Chopade. Antinociceptive Investigations of Rubiadin in Chronic pain induced by Freund’s adjuvant in mice. Research Journal of Pharmacy and Technology 2023; 16(1):31-4. doi: 10.52711/0974-360X.2023.00006   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-1-6


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