Author(s):
Hanan Faleh Mohsein, Faten Nsaif Jasim
Email(s):
alihasan198054@yahoo.com
DOI:
10.52711/0974-360X.2023.00054
Address:
Hanan Faleh Mohsein1*, Faten Nsaif Jasim2
1Assistant Prof., Department of Chemistry, College of Education for Girls, Kufa University, Iraq.
2M.Sc. Student, Department of Chemistry, College of Education for Girls, Kufa University, Iraq.
*Corresponding Author
Published In:
Volume - 16,
Issue - 1,
Year - 2023
ABSTRACT:
In the present work , 4-((dicyanomethyl)diazenyl)-N-(5-methylisoxazol-3-yl)benzene sulfonamide E and 2,2'-(1E,1E')-(sulfonylbis(4,1-phenylene))bis(diazene-2,1-diyl) dimalononitrile C were synthesized from the reaction of Sulfamethaxazole and Dapsone with Malononitrile and condensed with 2,4dinitophenyl hydrazine derivatives to produce 3,5diaminopyrazole derivatives E1 and C1.condensation with hydroxyl amine hydrochloride produce isoxazole derivative E2,C2 .Treatment of E and C with urea and thiourea yielded the pyrimidine derivatives E3-E4,C3-C4 and treatment with secondary amine afforded piperazine derivatives E5,C5. While its condensation with thiosemicarbazide yielded the derivatives E6, C6. The structure of the newly synthesized compound were established on the basis of physical data and spectral methods such as IR, 1H-NMR ,13C-NMR and Mass spectra. Cytotoic evaluation of four compounds, against MCF-7 (human breast adeno carcinoma) cell lines.
Cite this article:
Hanan Faleh Mohsein, Faten Nsaif Jasim. Synthesis, Spectroscopic Study of new Substituted heterocyclic compounds derived from Molononitrile and Cytotoxic agents against MCF-7 Human Cancer Cells. Research Journal of Pharmacy and Technology 2023; 16(1):301-6. doi: 10.52711/0974-360X.2023.00054
Cite(Electronic):
Hanan Faleh Mohsein, Faten Nsaif Jasim. Synthesis, Spectroscopic Study of new Substituted heterocyclic compounds derived from Molononitrile and Cytotoxic agents against MCF-7 Human Cancer Cells. Research Journal of Pharmacy and Technology 2023; 16(1):301-6. doi: 10.52711/0974-360X.2023.00054 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-1-54
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