Author(s): Hanan Faleh Mohsein, Faten Nsaif Jasim

Email(s): alihasan198054@yahoo.com

DOI: 10.52711/0974-360X.2023.00054   

Address: Hanan Faleh Mohsein1*, Faten Nsaif Jasim2
1Assistant Prof., Department of Chemistry, College of Education for Girls, Kufa University, Iraq.
2M.Sc. Student, Department of Chemistry, College of Education for Girls, Kufa University, Iraq.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2023


ABSTRACT:
In the present work , 4-((dicyanomethyl)diazenyl)-N-(5-methylisoxazol-3-yl)benzene sulfonamide E and 2,2'-(1E,1E')-(sulfonylbis(4,1-phenylene))bis(diazene-2,1-diyl) dimalononitrile C were synthesized from the reaction of Sulfamethaxazole and Dapsone with Malononitrile and condensed with 2,4dinitophenyl hydrazine derivatives to produce 3,5diaminopyrazole derivatives E1 and C1.condensation with hydroxyl amine hydrochloride produce isoxazole derivative E2,C2 .Treatment of E and C with urea and thiourea yielded the pyrimidine derivatives E3-E4,C3-C4 and treatment with secondary amine afforded piperazine derivatives E5,C5. While its condensation with thiosemicarbazide yielded the derivatives E6, C6. The structure of the newly synthesized compound were established on the basis of physical data and spectral methods such as IR, 1H-NMR ,13C-NMR and Mass spectra. Cytotoic evaluation of four compounds, against MCF-7 (human breast adeno carcinoma) cell lines.


Cite this article:
Hanan Faleh Mohsein, Faten Nsaif Jasim. Synthesis, Spectroscopic Study of new Substituted heterocyclic compounds derived from Molononitrile and Cytotoxic agents against MCF-7 Human Cancer Cells. Research Journal of Pharmacy and Technology 2023; 16(1):301-6. doi: 10.52711/0974-360X.2023.00054

Cite(Electronic):
Hanan Faleh Mohsein, Faten Nsaif Jasim. Synthesis, Spectroscopic Study of new Substituted heterocyclic compounds derived from Molononitrile and Cytotoxic agents against MCF-7 Human Cancer Cells. Research Journal of Pharmacy and Technology 2023; 16(1):301-6. doi: 10.52711/0974-360X.2023.00054   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-1-54


REFERENCES:
1.    Pankaj K. Abhishek K. Jean S P. Sachin A K. Nanditha B. Prashant N. Synthesis and antimicrobial evaluation of some novel 1,5 benzodiazepine derivatives derived from pyrrolyl chalcones. Research Journal of Pharmacy and Technology. 2022; 15(4):1811-4. doi: 10.52711/0974-360X.2022.00304
2.    Vishnu A. Adole, Abhijit R. Bukane, Ravindra H. Waghchaure, Rohit S. Shinde, Bapu S. Jagdale. Computational Study on Molecular Structure, UV-Visible and Vibrational Spectra and Frontier Molecular Orbital Analysis of (E)-7-((2-Chloroquinolin-3-yl)methylene)-1,2,6,7-tetrahydro-8H-indeno[5,4-b]furan-8-one. Research Journal of Pharmacy and Technology. 2022; 15(3):1101-8. doi: 10.52711/0974-360X.2022.00184
3.    Chetan Savant, Venkatrao Kulkarni, Prasanna Habbu, Preeti Kulkarni, Muhammed Majeed, Mahadeva Nayak. Screening of Novel Hybrid Combinations of Synthetic Drugs with Plant Extracts for its In vitro Antioxidant Activity. Research Journal of Pharmacy and Technology. 2022; 15(1):188-2. doi: 10.52711/0974-360X.2022.00030 .
4.    MP. Coleman , M. Quaresma, F. Berrino., Cancer survival in five continents : a worldwide population-based study (CONCORD). Lancet Oncol. , 9(8):730-756 , (2008)
5.    Mariya J. Jayaprakash A. Phytochemical Analysis and In Vitro Anticancer Activity of Enteromorpha compressa against Ovarian Cancer. Research Journal of Pharmacy and Technology. 2022; 15(5):1943-7. doi: 10.52711/0974-360X.2022.00323
6.    Gopal Muthu Boopathi, Shanmugarajan T. S. Synthesis, Characterisation and Antimicrobial Activity of Novel 2-Methyl-3-(2-(substituted ylidene)hydrazinyl)quinazolin-4(3H)-ones. Research Journal of Pharmacy and Technology. 2022; 15(5):2176-2183. doi: 10.52711/0974-360X.2022.00362
7.    Rajaa A A. Nor A A. Nagham M A. Synthesis of Triazole Derivatives via Multi Components Reaction and Studying of (Organic Characterization, Chromatographic Behavior, Chem-Physical Properties)., Egyptian Journal of Chemistry. 2020., 63(11), pp. 4163 - 4174 ., DOI: 10.21608/EJCHEM.2020.23541.2399 .
8.    Nagham M A. Synthesis and Chemical Identification of Macro Compounds of (Thiazol and Imidazol)., Research Journal of Pharmacy and Technology.; 2015 ,8(1), 78-84., DOI: 10.5958/0974-360X.2015.00016.5.
9.    Mehvish A K. Synthesis and Evaluation of Anticancer activity of some new 3(2h)-one pyridazinone derivatives by Molecular Docking Studies. Research Journal of Pharmacy and Technology. 2022; 15(5):2279-4. doi: 10.52711/0974-360X.2022.00379 .
10.    Edon V. David T. Smith, Jon T. Njardarson. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals .; 2014 .,J. Med. Chem. 57 (24): 10257–10274. doi:10.1021/jm501100b
11.    N. Arumugam, A. I. Almansour, R. S. Kumar, D. M. Al-Thamili, G. Periyasami, V. S. Periasamy, J. Athinarayanan, A. A. Alshatwi, S. M. Mahalingam, J. C. Menéndez, .Chemistry Central Journal ., 2018., 12, 1.
12.    W. M. Eldehna, D. H. EL-Naggar, A. R. Hamed, H. S. Ibrahim, H. A. Ghabbour, H. A. Abdel-Aziz, Journal of enzyme inhibition and medicinal chemistry, 33, 309, (2018).
13.    Chaniyara R., Tala S., Chen C.W., Lee P.C., Kakadiya R., Dong H., Marvania B., Chen C.H., Chou T.C., Lee T.C., Synthesis and antitumor evaluation of novel Benzo[d]pyrrolo[2,1-b] thiazole derivatives. Eur. J. Med. Chem. 2012;53:28–40. doi: 10.1016/j.ejmech.2012.03.030
14.    Ghorab M.M., Bashandy M.S., Alsaid M.S. Novel thiophene derivatives with sulfonamide, isoxazole, benzothiazole, quinoline and anthracene moieties as potential anticancer agents. Acta Pharm. 2014;64:419–431. doi: 10.2478/acph-2014-0035.
15.    60. Carter J.S., Kramer S., Talley J.J., Penning T., Collins P., Graneto M.J., Seibert K., Koboldt C.M., Masferrer J., Zweifel B. Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors. Bioorg. Med. Chem. Lett. 1999;9: 1171–1174. doi: 10.1016/S0960-894X(99)00157-2
16.    García-Valverde M., Torroba T. Special Issue: Sulfur-Nitrogen Heterocycles. Molecules . 2005;10:318–320. doi: 10.3390/10020318.
17.    Khan I., Ibrar A., Abbas N. Triazolothiadiazoles and triazolothiadiazines-Biologically attractive scaffolds. Eur. J. Med. Chem. 2013;63:854–868. doi: 10.1016/j.ejmech.2013.01.060.
18.    Husain A., Rashid M., Shaharyar M., Siddiqui A.A., Mishra R. Benzimidazole clubbed with triazolo-thiadiazoles and triazolo-thiadiazines: New anticancer agents. Eur. J. Med. Chem. 2013 ; 62:785–798. doi: 10.1016/j.ejmech.2012.07.011.
19.    Husain A., Rashid M., Mishra R., Parveen S., Shin D.S., Kumar D. Benzimidazole bearing oxadiazole and triazolo-thiadiazoles nucleus: Design and synthesis as anticancer agents. Bioorg. Med. Chem. Lett. 2012;22:5438–5444. doi: 10.1016/j.bmcl.2012.07.038.
20.    Kamel M.M., Megally Abdo N.Y. Synthesis of novel 1,2,4-triazoles, triazolothiadiazines and triazolothiadiazoles as potential anticancer agents. Eur. J. Med. Chem. 2014;86:75–80. doi: 10.1016/j.ejmech.2014.08.047.
21.    El-Sawy E.R., Mandour A.H., El-Hallouty S.M., Shaker K.H., Abo-Salem H.M. Synthesis, antimicrobial and anticancer activities of some new N-methylsulphonyl and N-benzene sulphonyl-3-indolyl heterocycles. 1st Cancer Update. Arab. J. Chem. 2013;6:67–78. doi: 10.1016/j.arabjc.2012.04.003.
22.    Mabkhot Y.N., Barakat A., Al-Majid A.M., Alshahrani S., Yousuf S., Choudhary M.I. Synthesis, reactions and biological activity of some new bis-heterocyclic ring compounds containing sulphur atom. Chem. Cent. J. 2013; 7(4) :112–120. doi: 10.1186/1752-153X-7-11

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available