Author(s):
Raghavendra Rao N G, Priyanka Gupta, Sheela M A
Email(s):
raghavendra.rao@kiet.edu , drngraghu@gmail.com
DOI:
Address:
Raghavendra Rao N G1*, Priyanka Gupta2, Sheela M A3
1Department of Pharmaceutics, KIET School of Pharmacy, KIET Group of Institutions, NCR-Delhi,
Ghaziabad-201206, Uttar Pradesh, India.
2Department of Pharmacy, GRD (PG) IMT, 214, Rajpur, Dehradun-248009 Uttarakhand, India.
3Rajkumar Goel Institute of Technology(Pharmacy), Rajkumar Goel Group of Institutions, Delhi-Meerut Road, Ghaziabad, UP, India- 201003.
*Corresponding Author
Published In:
Volume - 16,
Issue - 1,
Year - 2023
ABSTRACT:
Objective: The aim of this present research work, the aim was to develop drug-loaded Bisoprolol fumarate quick-dissolving tablets by direct compression method by using Trigonella Foenum - Plantago ovata seeds mucilage. Comparative studies between synthetic and natural superdisintegrants. Bisoprolol Fumarate is an antihypertensive drug incorporated in handling hypertension, and as a prophylaxis treatment of angina pectoris, heart failure. Methods: Bisoprolol fumarate-loaded tablets were developed, estimated for different pre and post-compressional parameters, FTIR study, and short-term stability studies. Results and Discussions: The FTIR spectral analysis results indicate no interaction between the drug and formulation additives. pre and post-compressional parameters were within the authorised Pharmacopeial limits, and the results were satisfactory. The disintegration time and dissolution investigations of formulations F12 and F15 were determined to be the most promising, with disintegration times of 22 and 24 secs, respectively. FormulationsF12 and F15 containing Trigonella Foenum and plantago ovata mucilage’s showed highest drug release above 99% within 20 and 25 min respectively. Trigonella Foenum mucilage and Plantago ovata was identified to be the better superdisintegrant compare to synthetic superdisintegrants. Stability studies to optimize the formulations were carried out for about 90 days. During the studies, no considerable changes were noticed in the compressed tablets for in-vitro disintegration time, hardness, friability and uniform distribution of drug content etc. Conclusion: Based on disintegration time the developed formulations F3, F12 and F15 were found to be mostly constitutive, with disintegration times of 30, 22, and 24 secs. The result outcome can be interpreted that the formulations loaded with Bisoprolol fumarate have shown enhanced dissolution rates that might have been the cause of improved bioavailability, subsequently an effective therapy by coupling with Trigonella foenum and Plantago ovata mucilage. These mucilages were plant-derived, non-toxic, bio-compatible, bio-degradable, and least side effects.
Cite this article:
Raghavendra Rao N G, Priyanka Gupta, Sheela M A. Trigonella foenum-Plantago Ovata Seeds Mucilage as a Superdisintegrants for the Development of Bisoprolol Fumarate Loaded Quick Dissolving Tablet (QDT). Research Journal of Pharmacy and Technology 2023; 16(1):23-0. doi: 10.52711/0974-360X.2023.00005
Cite(Electronic):
Raghavendra Rao N G, Priyanka Gupta, Sheela M A. Trigonella foenum-Plantago Ovata Seeds Mucilage as a Superdisintegrants for the Development of Bisoprolol Fumarate Loaded Quick Dissolving Tablet (QDT). Research Journal of Pharmacy and Technology 2023; 16(1):23-0. doi: 10.52711/0974-360X.2023.00005 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-1-5
REFERENCES:
1. Rajitha K, Shravan YK, Adukondalu D, Ramesh G, Rao YM. Formulation and evaluation of orally disintegrating tablets of buspirone. Int J Pharm Sci Nanotechnol 2009; 1:327-34. doi.org/10.37285/ijpsn.2008.1.4.3.
2. Chang RK X. Guo BA. Burnside RA. Cough. Fast dissolving tablets. Pharm Tech 2000; 24:52-58. E-LIBRARY ID: 6095733.
3. Yeola BS, Pisal SS, Paradkar AR, Mahadik KR. New drug delivery systems. Indian Drugs 2000; 37(7):312-318.
4. Watanabe Y, Koizumi K, Zama Y, Kiriyama M, Matsumoto Y, Matsumoto M. New compressed tablet rapidly disintegrating in saliva in the mouth using crystalline cellulose and a disintegrant. Biol Pharm Bull 1995; 18(9):1308-10. DOI: 10.1248/bpb.18.1308.
5. Bi Y, Sunada H, Yonezawa Y, Danjo K, Otsuka A, Iida K. Preparation and evaluation of a compressed tablet rapidly disintegrating in the oral cavity. Chem Pharm Bull (Tokyo) 1996;44(11):2121-7. DOI: 10.1248/cpb.44.2121.
6. Ishikawa T, Watanabe Y, Utoguchi N, Matsumoto M. Preparation and evaluation of tablets rapidly disintegrating in saliva containing bitter taste masked granules by the compression method. Chem Pharm Bull (Tokyo) 1999; 47:1451-4. DOI: 10.1248/cpb.47.1451.
7. Ishikawa T, Koizumi N, Mukai B, Utoguchi N, Fujii M, Matsumoto M, et al. Pharmacokinetics of acetaminophen from rapidly disintegrating compressed tablet prepared using microcrystalline cellulose (PH-M-06) and spherical sugar granules. Chem Pharm Bull (Tokyo) 2001; 49:230-2. DOI: 10.1248/cpb.49.230.
8. Grassano A, Marchiorri M, Ditoro M, Castegin F. Fast dissolving compositions having analgesic activity. US patent. 2001; 6:197, 336. I E990557A1.
9. Gills PM, Deconde VF. Fast dissolving galanthamine hydrobromide tablet. US patent. 2000; 6:099.863. US6099863A.
10. Makooi Morehead WT, Buehler JD, Landmann BR. Formulation of fast dissolving efavirenz capsules or tablets using super disintegrants, US patent. 2001; 6:238, 695. US6238695B1.
11. Grassano A, Marchiorri M, Ditoro M, Castegin F. Fast dissolving compositions having analgesic activity. US Patent. 2001; 6:197, 336. EP 1 100 470 B1.
12. Chue P, Welch R, Binder C. Acceptability and disintegration rates of orally disintegrating risperidone tablet in patients with schizophrenia or schizoaffective disorder. Can. Jr. Psychiatry. 2004; 49:701-3. doi: 10.1177/070674370404901009.
13. Shu T, Suzuki H, Hirohonda, K. Studies of rapidly disintegrating tablets in oral cavity using co-ground mixture of mannitol with crospovidone. Chem. Pharm. Bull. (Tokyo). 2002; 50:193-8. DOI: 10.1248/cpb.50.193.
14. Seager H, Drug delivery products and the zydis fast dissolving dosage form. Jr. Pharm. Pharmacol. 1998; 50:375-382. DOI: 10.1111/j.2042-7158.1998.tb06876.x.
15. Fini Adamo, Valentina Bergamanate, Gian Carlo Ceschel, Celestino Ronchi, Carlos Alberto Fonseca de Moraces, Fast dispersible/slow releasing ibuprofen tablets, Eur.Jr. Pharm and biopharm. 2007: 335-341. DOI: 10.1016/j.ejpb.2007.11.011.
16. Seong Hoon Jeong, Yuuki Takaishi, Yourong fu and Kinam Park. Material properties for making fast dissolving tablet by a compression method. J. Mater. Chem. 2008; 18:3527-3535. doi.org/10.1039/B800209F.
17. Dobetti L. Fast melting tablets: Developments and Technologies. Pharma Tech 2001; Suppl:44-50. Corpus ID: 13788707.
18. Kuchekar BS, Arumugam V. Fast dissolving tablets. Indian J Pharm Educ Res 2001; 35:150-2.
19. Sean C, and Sweetman A, "Martindale the Complete Drug Refrences" 35th edited by Phamaceutical Press, 2006. p875.
20. Prichard BN. Bisoprolol: a new betaadrenoceptor blocking drug. Eur. Heart J. Suppl 1M., 1987. 121(9). DOI: 10.1093/eurheartj/8.suppl_m.121.
21. Washi SP, Sharma VD and Sinha P. (1985). Plantago ovata: genetic diversity, cultivation, utilization and chemistry. Indian J Nat Prod.1:3-6. D OI: https://doi.org/10.1079/PGR200582.
22. Bavega SK, Rao KV and Arora J. (1989). Examination of natural gums and mucilages as sustaining materials in tablet dosage forms. Part-II. Indian J Pharm Sci.51:115-118.
23. Basawaraj S. Patil, Raghavendra Rao NG. Formulation and evaluation of fast dissolving tablets of Candesartan Cilexetil using natural and synthetic Superdisintegrants. Journal of Applied Pharmacy. JAP: 03(03): 250-261 (2011). doi:10.21065/19204159.3.250.
24. Vikash Jakhmola, Raghavendra Rao NG, Raja Ram Mohan Rai. Formulation and Evaluation of Mouth dissolving tablet of Zafirlukast using directly compressible excipients: a Review. International Journal of Research and Analytical Reviews (IJRAR): May 2020, 7(2):189-193. IJRAR19L1410.
25. Chandran CS, Shijith KV, Vipin, Augusthy AR. Chitosan Based Mucoadhesive Buccal Patches Containing Bisoprolol Fumarate. Int J Adv Pharm Bio Chem. 2013; 2(3): 465-469. ID: 53605331
26. Basawaraj S.Patil, Raghavendra Rao NG, Dayakar Rao K. Formulation and Evaluation of Fast Dissolving Tablets of Granisetron Hydrochloride. International Journal of Applied Biology and Pharmaceutical Technology. IJABPT: Vol: 2: Issue-2: Apr-June 2011, 22-28.
27. Basawaraj S. Patil, Raghavendra Rao NG. Enhanced Dissolution and Bioavailability of Granisetron Hydrochloride By Direct Compression Technique.International Journal of Medical and Pharmaceutical Sciences. IJMPS:2011: Vol 1: issue 4; 1-9.
28. Priyanka Joshi, Manju, Mohd Vaseem Fateh, Raghavendra Rao NG. Review on Mouth Dissolving Tablet. Asian Journal of Pharmaceutical Research. AJPR: 9(1): January- March, 2019: 42-54. DOI: 10.5958/2231-5691.2019.00008.X .
29. Prathibha Suvarna, Ravi Kumar, Yamunappa, Pooja Shetty, Narayana Swamy VB. Development and In Vitro Evaluation of Fast Dissolving Tablets of Tapentadol. Asian Journal of Pharmaceutical Research. Asian J. Pharm. Res. 6(1): January -March, 2016; Page 11-21. DOI: 10.5958/2231-5691.2016.00003.4.
30. Avinash Bhagwat, Suhas M Kakade, Chirag V Naval, Mukesh Tilker, Ravindra M Walture, Sagar A Adichwal, and Atul P Chaudhari. Formulation and Evaluation of Mouth Dissolving Tablets of Domperidone. Research Journal of Pharmacy and Technology. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 821-824.
31. Mahaveer Singh, Gautam Singhvi, SG Kaskhedikar, Love soni. Development of Fast Dispersible Tablets of Carvedilol: Effect of Functionality of Superdisintegrants. Research Journal of Pharmacy and Technology. Research J. Pharm. and Tech.3 (3): July-Sept. 2010; Page 942-944
32. Bhalerao AV, Deshkar SS, Shirolkar SV, Gharge VG, Deshpande AD. Development and Evaluation of Clonazepam Fast Disintigrating Tablets Using Superdisintigrates and Solid Dispersion Technique. Research Journal of Pharmacy and Technology. Research J. Pharm. and Tech.2(2): April.-June.2009; Page 375-377.
33. Jagdale SC, Chabukswar AR, Kuchekar BS, Padalkar AN, Kale AU. Comparative Evaluation of Superdisintegrants with Formulation Development of Orodispersible Tablets of Mosapride Citrate Dihydrate. Research J. Pharm. and Tech. 2(1): Jan.-Mar. 2009; Page 91-96.
34. Uday S Rangole, PS Kawtikwar, DM Sakarkar. Formulation and In-vitro Evaluation of Rapidly Disintegrating Tablets Using Hydrochlorothiazide as a Model Drug. Research J. Pharm. and Tech. 1(4): Oct.-Dec. 2008; Page 349-352.
35. Shailesh Sharma, Sudhir Bharadwaj, Gupta GD. Fast dissolving tablets of Promethazine theoclate by using natural superdisintegrants. Research J. Pharm. and Tech. 1(3): July-Sept. 2008; Page 218-224.
36. Chitra Govind Rajput. Formulation and Evaluation of Fenugreek powder as Nutraceutical from seeds of Trigonella foenum graecum. Research Journal of Pharmacognosy and Phytochemistry. Res. J. Pharmacognosy and Phytochem. 2021; 13(2):78-80. DOI: 10.52711/0975-4385.2021.00013.
37. Raghavendra Rao NG, Durga Bhavani, Shwetha. Design and Evaluation of Valsartan Fast dissolving Tablets by Direct Compression Method. Indo-American Journal of Pharm Research. IAJPR:2015:5(01)158-168.