Author(s): Indah Amalia Amri, Hilmi Praja Suradinata, Fidi Nur Aini EPD, Ida Bagus Gde Rama Wisesa

Email(s): indahamaliaamri@ub.ac.id

DOI: 10.52711/0974-360X.2023.00043   

Address: Indah Amalia Amri1*, Hilmi Praja Suradinata2, Fidi Nur Aini EPD1, Ida Bagus Gde Rama Wisesa3
1Laboratory of Microbiology and Immunology, Faculty of Veterinary Medicine, Universitas Brawijaya.
2Undergraduate Student, Faculty of Veterinary Medicine, Universitas Brawijaya.
3Laboratory of Physiology Veterinary, Faculty of Veterinary Medicine, Universitas Brawijaya.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2023


ABSTRACT:
Oregano leaves (Origanum vulgare) are potentially known as antibacterial agent. Colibacillosis is an infectious disease caused by Escherichia coli as the primary agent. Besides that, E.coli reported inducing various other systemic diseases that harm human health and the economy due to the massive transmission of bacteria in humans and livestock. This study investigated the potential use of oregano leaves to overcome the growth of E. coli in the colibacillosis mice model. Mice were infected with the E. coli, then administered with oregano leaf extract with increasing doses of 5mg/kg BW, 10mg/kg BW, and 20mg/kg BW. The spleen was collected and the histopathology and histomorphometry were analyzed. Administration of oregano leaf extract showed the potential to significantly reduce the rate of tissue damage (p<0.05) through the reduction of the size of white pulp, an indicator of the immune system's active resistance in overcoming pathogenic bacterial infections. It can be concluded that oregano extract improved the white pulp enlargement of spleen.


Cite this article:
Indah Amalia Amri, Hilmi Praja Suradinata, Fidi Nur Aini EPD, Ida Bagus Gde Rama Wisesa. The Impact of Oregano Extract (Origanum vulgare) on Spleen Histomorphometry of the Colibacillosis Mouse Model. Research Journal of Pharmacy and Technology 2023; 16(1):236-0. doi: 10.52711/0974-360X.2023.00043

Cite(Electronic):
Indah Amalia Amri, Hilmi Praja Suradinata, Fidi Nur Aini EPD, Ida Bagus Gde Rama Wisesa. The Impact of Oregano Extract (Origanum vulgare) on Spleen Histomorphometry of the Colibacillosis Mouse Model. Research Journal of Pharmacy and Technology 2023; 16(1):236-0. doi: 10.52711/0974-360X.2023.00043   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-1-43


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