Author(s): Retno Pudji Rahayu, Bambang Sumaryono, Nadia Farikha Sandi

Email(s): a-retno-p-r@fkg.unair.ac.id

DOI: 10.52711/0974-360X.2023.00019   

Address: Retno Pudji Rahayu, Bambang Sumaryono, Nadia Farikha Sandi 1Department of Oral and Maxillofacial Pathology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia. *Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2023


ABSTRACT:
Type 2 diabetes mellitus is a disease caused by insulin resistance which will cause blood glucose levels to increase. That factor can result in an increase of proinflammatory cytokines such as TNF-alpha dan IL-1 beta which will cause the severity of the disease gets worse. Intraoral antidiabetic drugs have several side effects; therefore, it is necessary to provide probiotic supplements such as Lactobacillus casei to reduce levels of TNF- alpha dan IL-1 beta so that type 2 diabetes mellitus doesn’t get worse. These bacteria can also increase levels of anti-inflammatory cytokines such as IL-10. This study aims to learn and understand more deeply about the potential of Lactobacillus casei on TNF- alpha and IL-1 beta levels in type 2 diabetes mellitus. Diabetes mellitus type 2 is a chronic disease by the pancreas not being able to produce the hormone insulin in large quantities due to insulin resistance caused by impaired insulin secretion in pancreas. TNF- alpha and IL-1 beta is a cytokines that plays role in the body’s defense function, if cytokines produce in excess amount it will increase the inflammatory process. Lactobacillus casei is a probiotic bacterium that can be found in yoghurt, cheese, raw meat, and other food ingredients. Lactobacillus casei has the potential to reduce TNF- alpha dan IL-1 beta levels in type 2 diabetes mellitus.


Cite this article:
Retno Pudji Rahayu, Bambang Sumaryono, Nadia Farikha Sandi. The Potential of Lactobacillus casei on TNF-alpha and IL-1Beta Levels Type 2 Diabetes Mellitus. Research Journal of Pharmacy and Technology 2023; 16(1):107-0. doi: 10.52711/0974-360X.2023.00019

Cite(Electronic):
Retno Pudji Rahayu, Bambang Sumaryono, Nadia Farikha Sandi. The Potential of Lactobacillus casei on TNF-alpha and IL-1Beta Levels Type 2 Diabetes Mellitus. Research Journal of Pharmacy and Technology 2023; 16(1):107-0. doi: 10.52711/0974-360X.2023.00019   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-1-19


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