Author(s):
Retno Pudji Rahayu, Bambang Sumaryono, Nadia Farikha Sandi
Email(s):
a-retno-p-r@fkg.unair.ac.id
DOI:
10.52711/0974-360X.2023.00019
Address:
Retno Pudji Rahayu, Bambang Sumaryono, Nadia Farikha Sandi
1Department of Oral and Maxillofacial Pathology, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
2Undergraduate Student, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
*Corresponding Author
Published In:
Volume - 16,
Issue - 1,
Year - 2023
ABSTRACT:
Type 2 diabetes mellitus is a disease caused by insulin resistance which will cause blood glucose levels to increase. That factor can result in an increase of proinflammatory cytokines such as TNF-alpha dan IL-1 beta which will cause the severity of the disease gets worse. Intraoral antidiabetic drugs have several side effects; therefore, it is necessary to provide probiotic supplements such as Lactobacillus casei to reduce levels of TNF- alpha dan IL-1 beta so that type 2 diabetes mellitus doesn’t get worse. These bacteria can also increase levels of anti-inflammatory cytokines such as IL-10. This study aims to learn and understand more deeply about the potential of Lactobacillus casei on TNF- alpha and IL-1 beta levels in type 2 diabetes mellitus. Diabetes mellitus type 2 is a chronic disease by the pancreas not being able to produce the hormone insulin in large quantities due to insulin resistance caused by impaired insulin secretion in pancreas. TNF- alpha and IL-1 beta is a cytokines that plays role in the body’s defense function, if cytokines produce in excess amount it will increase the inflammatory process. Lactobacillus casei is a probiotic bacterium that can be found in yoghurt, cheese, raw meat, and other food ingredients. Lactobacillus casei has the potential to reduce TNF- alpha dan IL-1 beta levels in type 2 diabetes mellitus.
Cite this article:
Retno Pudji Rahayu, Bambang Sumaryono, Nadia Farikha Sandi. The Potential of Lactobacillus casei on TNF-alpha and IL-1Beta Levels Type 2 Diabetes Mellitus. Research Journal of Pharmacy and Technology 2023; 16(1):107-0. doi: 10.52711/0974-360X.2023.00019
Cite(Electronic):
Retno Pudji Rahayu, Bambang Sumaryono, Nadia Farikha Sandi. The Potential of Lactobacillus casei on TNF-alpha and IL-1Beta Levels Type 2 Diabetes Mellitus. Research Journal of Pharmacy and Technology 2023; 16(1):107-0. doi: 10.52711/0974-360X.2023.00019 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-1-19
REFERENCES:
1. Zamaa MS. Sainudin S. Hubungan Kepatuhan Pengobatan dengan Kadar Gula Darah Sewaktu pada Pasien Diabetes Melitus Tipe II. JAmbura Nursing Journal. 2019; 1(1):11–18.doi:10.37311/jnj.v1i1.2057.
2. Rao USM. Zin T. Kyi Kyi WRN. Subramaniam SA/L. Shan TB. Mogan KA/P. Ismail ASB. Cross-Sectional Study on Knowledge, Attitude and Practice Regarding Diabetes Mellitus among Medical and Non-Medical Students. Research Journal of Pharmacy and Technology. 2018; 11(11):4837–4841.doi:10.5958/0974-360X.2018.00879.X.
3. Internasional Diabetes Federation. Managing Type 2 Diabetes in Primary Care. 2020.
4. Shita, ADP. Perubahan Level TNF-α Dan IL-1 pada Kondisi Diabetes Mellitus. Pros Dent Sci Meet II, Fakultas Kedokteran Gigi, Universitas Jember.2015; 1:11–7.
5. Fatimah RN. Diabetes Melitus Tipe 2. Jurnal Majority.2015; 4 (5):93-101
6. Zhao G. Dharmadhikari G. Maedler K. Meyer-Hermann M. Possible Role of Interleukin-1β in Type 2 Diabetes Onset and Implications for Anti-Inflammatory Therapy Strategies. Public Library of Science. 2014; 10(8):e1003798.doi:10.1371/journal.pcbi.1003798.
7. Chen P. Zhang Q. Dang H. Liu X. Tian F. Zhao J. et al. Antidiabetic Effect of Lactobacillus casei CCFM0412 on Mice with Type 2 Diabetes Induced by a High-Fat Diet and Streptozotocin. Nutrition. 2014; 30(9):1061–1068.doi:10.1016/j.nut.2014.03.022.
8. Amdekar DS. Singh V. Singh DR. Sharma DP. Keshav P. Kumar A. Lactobacillus casei Reduces the Inflammatory Joint Damage Associated with Collagen-Induced Arthritis (CIA) by Reducing the Pro-Inflammatory Cytokines. Journal of Clinical Immunology. 2011; 31:147–154.doi:10.1007/s10875-010-9457-7.
9. Amdekar S. Singh V. Kumar A. Sharma P. Singh R. Lactobacillus casei and Lactobacillus acidophilus Regulate Inflammatory Pathway and Improve Antioxidant Status in Collagen-Induced Arthritic Rats. Journal of Interferon and Cytokine Research: The Official Journal of the International Society for Interferon and Cytokine Research. 2013; 33(1):1–8.doi:10.1089/jir.2012.0034.
10. Preethikaa S. Brundha MP. Awareness of Diabetes Mellitus among General Population. Research Journal of Pharmacy and Technology. 2018; 11(5):1825–1829.doi:10.5958/0974-360X.2018.00339.6.
11. Aydoğdu S. Karamese M. Altoparlak Ü. Karameşe S. The Protective Effects of Long-Term Probiotic Application on Experimental Sepsis-Dependent Inflammation Process. Bezmialem Science. 2019; 7:180–185.doi:10.14235/bas.galenos.2018.2643.
12. Azrimaidaliza A. Asupan Zat Gizi Dan Penyakit Diabetes Mellitus. Jurnal Kesehatan Masyarakat Andalas. 2011; 6(1):36–41.doi:10.24893/jkma.v6i1.86.
13. Ali S. Kadhum. Jwad ZA. Raheem HN. Noor H. Yaseen. Ali YK. Comparing The Levels of Trace Elements in Females with Diabetes Mellitus. Research Journal of Pharmacy and Technology. 2019; 12(12):6119–6123.doi:10.5958/0974-360X.2019.01063.1.
14. Vanmathi S. Star M. Jishala MI. Sunadaram R. A Pathophysiological Approach of Macrovascular Complication in Diabetes Mellitus with Hypertension: A Systematic Review. Research Journal of Pharmacy and Technology. 2019; 12(2):901–906.doi:10.5958/0974-360X.2019.00154.9.
15. Sutawardana, JH. Yulia. Waluyo, A. Studi Fenomenologi Pengalaman Penyandang Diabetes Melitus yang Pernah Mengalami Episode Hipoglikemia. 2016; 1(1):159–175.
16. Varghese L. Murthi K. Pandey K. Teneligliptin as an Add on Therapy to Oral Anti Diabetic Agents in Type 2 Diabetes Mellitus. Research Journal of Pharmacy and Technology. 2020; 13(5):2310–2314.doi:10.5958/0974-360X.2020.00416.3.
17. Alza Y. Hubungan Hiperglikemia dengan Kadar Glyceraldehyde-3-Phosphate Dehydrogenase (GAPDH) pada Penderita Diabetes Mellitus Tipe 2. Photon: Jurnal Sain dan Kesehatan. 2013; 4(1):19–26.doi:10.37859/jp.v4i1.165.
18. Yerizel E. Hendra P. Edwar Z. Bachtiar H. Pengaruh Hiperglikemia Terhadap High Sensitive C Reactive Protein (Hs-CPR) pada Penderita Diabetes Melitus Tipe 2. Seminar Ilmiah Perhimpunan Biokimia dan Bologi Molekuler Indonesia. Fakultas Kedokteran: Universitas Gadjah Mada. 2015; 51-55.
19. Purwaningsih W. Pemberian Suspensi Bubuk Kedelai Dapat Menurunkan Kadar Malondialdehid (Mda) Serum pada Tikus Putih Diabetus Melitus yang Diinduksi Streptozotozin. 2012; 9(2):7.
20. Sangeetha R. Jayaraj V. Stress Induced Type 2 Diabetes Mellitus among Industrial Workers – A Review. Research Journal of Pharmacy and Technology. 2019; 12(1):396–402.doi:10.5958/0974-360X.2019.00072.6.
21. Maheshwari P. Shanmugarajan TS. Evaluation of Prescribing Practices of Metformin in Patients with Type-2 Diabetes Mellitus. Research Journal of Pharmacy and Technology. 2019; 12(2):531–534.doi:10.5958/0974-360X.2019.00093.3.
22. Fayyadh AA. Ibrahim H. Zain HHM. Al-Qubaisi MS. The Effect of Agarwood Leaf Extracts on Blood Glucose Level of Type II Diabetes Mellitus in ICR Male Mice. Research Journal of Pharmacy and Technology. 2020; 13(1):237–242.doi:10.5958/0974-360X.2020.00048.7.
23. Shita ADP. Perubahan Level TNF-α Dan IL-1 pada Kondisi Diabetes Mellitus. Pros Dent Sci Meet II, Fakultas Kedokteran Gigi, Universitas Jember. 2015; 1:1–7.doi:10.1017/CBO9781107415324.004.
24. Aronson JK. Meyler’s Side Effects of Drugs. Elsevier Science. 2015.
25. Senthilnathan B. Vivekanandan K. Bhavya E. Masilamani SPB. Impact of Nanoparticulate Drug Delivery System of Herbal Drug in Control of Diabetes Mellitus. Research Journal of Pharmacy and Technology. 2019; 12(4):1688–1694.doi:10.5958/0974-360X.2019.00282.8.
26. Akash MSH. Rehman K. Liaqat A. Tumor Necrosis Factor-Alpha: Role in Development of Insulin Resistance and Pathogenesis of Type 2 Diabetes Mellitus. Journal of Cellular Biochemistry. 2018; 119(1):105–110.doi:10.1002/jcb.26174.
27. Hassan MM. The Significance of Interleukin 4 (IL-4) (590-C/T) Gene Polymorphism in Iraqi Patients with Type 2 Diabetes Mellitus: A Case-Control Study. Research Journal of Pharmacy and Technology. 2019; 12(11):5133–5137.
28. Hwang DH. Encyclopedia of Human Nutrition. Elsevier Inc., Philadelphia. 2013; 2–4.
29. Maghzi AH. Minagar A. IL1-β Expression in Multiple Sclerosis. Journal of the Neurological Sciences. 2014; 343(1):1.doi:10.1016/j.jns.2014.05.009.
30. Herder C. Donath MY. Interleukin-1 Receptor Antagonist: Friend or Foe to the Heart? The Lancet. Diabetes & Endocrinology. 2015; 3(4):228–229.doi:10.1016/S2213-8587(15)00035-2.
31. Soelistijo SA. Novida H. Rudijanto A. Soewondo P. Suastika K. Manaf A. et al. Konsesus Pengelolaan dan Pencegahan Diabetes Melitus Tipe 2 di Indonesia 2015. Pengurus Besar Perkumpulan Endokrionologi Indonesia (PB PERKENI). 2015.
32. Laeli H. Nazaruddin N. Werdiningsih W. Kajian Sifat Kimia Dan Organoleptik Yogurt Jagung Manis (Zea Mays Saccharata) dengan Menggunakan Beberapa Jenis Inokulum. Pro Food. 2017; 2(1):77–84.
33. Gobetti M. Minervini F. Encyclopedia of Food Microbiology. Elsevier. 2013; 432-438.
34. Kellow NJ. Coughlan MT. Savige GS. Reid CM. Effect of Dietary Prebiotic Supplementation on Advanced Glycation, Insulin Resistance and Inflammatory Biomarkers in Adults with Pre-Diabetes: A Study Protocol for a Double-Blind Placebo-Controlled Randomised Crossover Clinical Trial. BMC Endocrine Disorders. 2014; 14(1):55.doi:10.1186/1472-6823-14-55.
35. Abbas AC. Al-Kraity WRH. Abbas EC. Effect Antioxidant and Serotonin Level in the Sera on Type II Diabetes Mellitus Males Patients and Compare with Control Group. Research Journal of Pharmacy and Technology. 2019; 12(5):2453–246010.5958/0974-360X.2019.00411.6.
36. Ermawati T. Periodontitis dan Diabetes Melitus. Stomatognatic-Jurnal Kedokteran Gigi. 2015; 9(3):152–154.
37. Yekti N. Rochmah YS. Mujayanto R. Analisa Profil Kadar C-Reactive Protein Pada Status Kesehatan Periodontal Pasien Diabetes Melitus Tipe 2 (Studi di Rumah Sakit Islam Sultan Agung Semarang). Odonto: Dental Journal 2014; 1(2):19–24.doi:10.30659/odj.1.2.19-24.
38. Huang SC. Lei YP. Lin CP. Hsiao PW. Chi YT. The Suppressive Effect of Supplementation of Combined Probiotic on Helicobacter Pylori Infection. Current Developments in Nutrition. 2020; 4 (Suppl 2):1565–1565.doi:10.1093/cdn/nzaa062_022.
39. Lesbros-Pantoflickova D. Corthésy-Theulaz I. Blum AL. Helicobacter Pylori and Probiotics. The Journal of Nutrition. 2007; 137 (3 Suppl 2):812S-8S.doi:10.1093/jn/137.3.812S.
40. Azad MAK. Sarker M. Wan D. Immunomodulatory Effects of Probiotics on Cytokine Profiles. BioMed Research International. 2018; 2018:e8063647.doi:10.1155/2018/8063647.
41. Miraghajani M. Dehsoukhteh SS. Hamedani SG. Sabihi S. Ghiasvand R. Potential Mechanisms Linking Probiotics to Diabetes: A Narrative Review of the Literature. Sao Paulo Med J. 2017; 135(2):169–178.doi: 10.1590/1516-3180.2016.0311271216.
42. Wang G. Li X. Zhao J. Zhang H. Chen W. Lactobacillus casei CCFM419 Attenuates Type 2 Diabetes via a Gut Microbiota Dependent Mechanism. Food & Function. 2017; 8 (9):3155–3164.doi:10.1039/c7fo00593h.
43. Li X. Wang E. Yin B. Fang D. Chen P. Wang G. et al. Effects of Lactobacillus casei CCFM419 on Insulin Resistance and Gut Microbiota in Type 2 Diabetic Mice. Beneficial Microbes. 2017; 8(3):421–432.doi:10.3920/BM2016.0167.
44. Gurung M. Li Z. You H. Rodrigues R. Jump DB. Morgun A. Shulzhenko, N. Role of Gut Microbiota in Type 2 Diabetes Pathophysiology. EBioMedicine. 2020; 51:102590.doi:10.1016/j.ebiom.2019.11.051.
45. Liu T. Zhang L. Joo D. Sun SC. NF-ΚB Signaling in Inflammation. Signal Transduction and Targeted Therapy. 2017; 2:17023.doi:10.1038/sigtrans.2017.23.
46. Tripolt NJ. Leber B. Blattl D. Eder M. Wonisch W. Scharnagl H. et al. Short Communication: Effect of Supplementation with Lactobacillus casei Shirota on Insulin Sensitivity, β-Cell Function, and Markers of Endothelial Function and Inflammation in Subjects with Metabolic Syndrome--a Pilot Study. Journal of Dairy Science.2013; 96(1):89–95.doi:10.3168/jds.2012-5863.