Author(s): Rana Alsamaan, Farah Alhakim

Email(s): rana.samaan@wpu.edu.sy

DOI: 10.52711/0974-360X.2023.00015   

Address: Rana Alsamaan*, Farah Alhakim
College of Pharmacy, Al-Wataniyah University, Hama, Syria.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2023


ABSTRACT:
Lots of herbal recipes are used Syria for treating and preventing gastric ulceration, especially the pomegranate peel powder, so the aim of this study was to investigate whether the pretreatment with pomegranate peel ethanolic extract PPEE in two doses (250, 500mg/kg) has any prophylactic effect on gastric mucosal damage caused by cold-restraint ulcer (CRU) in rats. It was noticed that pretreatment for four weeks was enough to protect the stomach, the ulcer index (UI) was macroscopically calculated and the stomach wall layers were histologically studied, the higher dose (500mg/kg) was more effective comparing with the lower one (250 mg/kg). These results suggest that the pomegranate peel ethanolic extract PPEE has special characteristics that make it useful for preventing from the gastric ulcers caused by stress.


Cite this article:
Rana Alsamaan, Farah Alhakim. Study of the protective effect of Pomegranate peel Ethanolic Extract on Gastric ulcer caused by stress on rats. Research Journal of Pharmacy and Technology 2023; 16(1):86-0. doi: 10.52711/0974-360X.2023.00015

Cite(Electronic):
Rana Alsamaan, Farah Alhakim. Study of the protective effect of Pomegranate peel Ethanolic Extract on Gastric ulcer caused by stress on rats. Research Journal of Pharmacy and Technology 2023; 16(1):86-0. doi: 10.52711/0974-360X.2023.00015   Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-1-15


REFERENCES:
1.    Nitu V. Madan, Mahesh S. Sahu, Yogeshwari T. Jambhulkar, Atreyee S. Mamidwar, Nilesh T. Hingawe, Amit N. Maliye. A Review on Euphorbiaceae plants for peptic ulcer. Res. J. Pharmacognosy and Phytochem. 2018; 10(4): 336-339. doi: 10.5958/0975-4385.2018.00054.7
2.    Bhattacharyya AS Chattopadhyay RA et al. Oxidative stress: An essential factor in the pathogenesis of gastrointestinal mucosal diseases. Physiol Rev. 2014 Apr 94: 329–354. DOI: 10.115/ physrev.00040.2012.
3.    Nitin Mahurkar, S.M. Sayeed Ul Hasan, Arati A. Malpani . Gastroprotective Influence of Vitamin C and its Combination with Rabeprazole in Pylorus Ligation Induced Ulcers. Asian J. Res. Pharm. Sci. 4(2): April-June 2014; Page 71-76.
4.    Dibyajyoti Saha, Ankit Tamrakar. Xenobiotics, Oxidative Stress, Free Radicals Vs. Antioxidants: Dance Of Death to Heaven’s Life. Asian J. Res. Pharm. Sci. 1(2): April-June 2011; Page 36-38.
5.    Plummer MA et al. Stress ulceration: prevalence, pathology and association with adverse outcomes, Plummer et al. Critical Care. 2014 Mar 18:213.  DOI: 10.1186/cc13780.
6.    K. HILLMAN. Acute Stress Ulceration. Anaesth Intens Care. 1985 Aug 13(3): 230-240.
7.    Yogesh Shivhare, Priya Singh, Radhika Gadekar, Prashant Soni. Botanicals as Antioxidants: A Renovate Review. Research J. Pharmacognosy and Phytochemistry 2010; 2(4): 255-259.
8.    Mohamed MA, Mabrok HO. Protective Effect of Pomegranate Peel Powder Against Gastric Ulcer in Rats. Biointerface Research in Applied Chemistry. 2022 Oct 12(4): 4888 – 4899. DOI: 10.33263/ BRIAC: 124.48884899.
9.    Al-badry FA. Efficacy of pomegranate peel (punica granatum) extract on gastric ulceration induced experimental rats. Biochem. Cell. Arch. 2019 Jan 19(2): 2865-2871DOI: 10.35124/bca.2019.19.2.2865.
10.    Ranjith Anishetty, Satya Swapna, B. Aishwarya, K. Chaitanya Sravanthi. Evaluation of antibacterial activity potential of extracts of Ricinus communis, Zingiber officinalis and Punica granatum in a Polyherbal Extract. Research J. Pharm. and Tech. 5(11): Nov. 2012; Page 1385-1388.
11.    Pankaj M. Chaudhari, Dheeraj T. Baviskar. Evaluation of Anti-leucodermal activity of medicinal plant in rats. Research J. Pharm. and Tech. 2020; 13(10):4731-4734. doi: 10.5958/0974-360X.2020.00833.1
12.    Maher Al-Absi, Abdu Faisal, Safwan Alagbarri, Mofeed Al- Nowihi. Development and Rheological Properties Evaluation of a Burn Healing Ointment Composed of Pomegranate peels and Beta-sitosterol Using Factorial Design. Asian J. Pharm. Tech. 2021; 11(1):59-65.
13.    Sánchez AN et al.Chemical Composition, Antioxidant Capacity, and Sensory Quality of Pomegranate (Punica granatum L.) Arils and Rind as Affected by Drying Method. Food Bioprocess Technol. 2012 Feb. DOI:10.1007/s11947-012-0790-0.
14.    Rajasekhar Pinnamaneni. Preliminary Phytochemical Investigation of peel of Pomegranate Punica granatum L. Research J. Pharm. and Tech 2018; 11(8): 3609-3613. doi: 10.5958/0974-360X.2018.00664.9.
15.    Keta Otilija et al. Pomegranate (Punica granatum L.) Peel Extract: Potential Cytotoxic Agent against Different Cancer Cell Lines. Rec. Nat. Prod. 2020 Feb 14(5):326-339.
16.    Dursun HA et al. Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. BMC Gastroenterology.  2009 9:36. DOI: 10.1186/1471-230X-9-36; PMID: 19457229.
17.    Morsy MO, Rofaeil RE.  Protective effects of nebivolol against cold restrant stress-induced gastric ulcer in rats: Role of NO, HO-1, and COX-1,2.  Nitric Oxide.  2012 Aug 27(2): 117-122. DOI: 10.1016/j.niox.2012.06.001.
18.    Robert A. et al. Effects of prostaglandin E1 on Gastric Secretion and Ulcer Formation in Rats. Gastroenterology. 1968 55(4): 481-487. PMID: 5698627.
19.    Xie WE et al. Esomeprazole alleviates the damage to stress ulcer in rats through not only its antisecretory effect but its antioxidant effect by inactivating the p38 MAPK and NF-κB signaling pathways.  Drug Design, Development and Therapy.  2019 13: 2969–2984. DOI: 10.2147/DDDT.S193641; PMID: 31686780.
20.    Chaturvedi AD et al. Effects of Ethanolic Extract of Eugenia Jambolana Seeds on Gastric Ulceration and Secretion in Rats.  Indian J PHysiol PHarmacol.  2007 Jun 51(2) : 131–140. PMID: 18175656.
21.    Nitin Dubey, Nidhi Dubey, RS Mehta, AK Saluja, DK Jain. Antiulcer Activity of a Traditional Pearl Preparation: Mukta Bhasma. Research J. Pharm. and Tech.2(2): April.-June.2009,;Page 287-290.
22.    Elsaed WA et al. Gastroprotective and antioxidant effects of fluvoxamine on stress-induced peptic ulcer in rats.  Journal of Taibah University Medical Sciences. 2018 May 13(5): 422-431. DOI: 10.1016/j.jtumed. 2018.04.010.
23.    Jadhav Sameer S., Salunkhe Vijay R. , Magdum Chandrakant S.. Daily Consumption of Antioxidants: -Prevention of Disease is better than Cure. Asian J. Pharm. Res. 3(1): Jan.-Mar. 2013; Page 33-39.
24.    Al-Rawahi AM et al. Phenolic Constituents of Pomegranate Peels (Punica granatum L.) Cultivated in Oman. European Journal of Medicinal Plants. 2014 Jan 4(3): 315-331.


Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available