Author(s):
Amol S. Dighe, Ashim K. Sen
Email(s):
amoldighe143@gmail.com , ashims01@gmail.com
DOI:
10.52711/0974-360X.2023.00001
Address:
Amol S. Dighe1,2*, Ashim K. Sen3
1PhD. Scholar, Department of Pharmacy, Sumandeep Vidyapeeth Deemed University, Pipariya, Vadodara, Gujarat State, India.
2Assistant Professor, Department of Pharmaceutical Chemistry, Pravara Rural College of Pharmacy, Loni (413736), MH, India.
3Professor, Department of Pharmacy, Sumandeep Vidyapeeth Deemed University, Pipariya, Vadodara, Gujarat State, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 1,
Year - 2023
ABSTRACT:
Triazolo-thiodiazole and related fused heterocyclic compounds are of interest as potential bioactive molecules. Triazolo-thiodiazole derivatives have attracted the attention of organic chemists due to their biological and chemotherapeutic significance. Research in the field of anti-mycobacterium, anti-inflammatory and anti-microbial therapies is ongoing and studies are seeking. Therefore, the discovery of new effective anti-mycobacterium, anti-inflammatory and antimicrobial agents is imperative. The literature survey indicates that the fuse ring of triazolo-thiazazole derivatives has proven to be a good bioactive molecule. They showed various biological activities such as antibacterial, antifungal, anti-inflammatory, tubercular, anticancer, anticonvulsant, antioxidant, analgesic. In view of the above facts it was felt that some were interested in triazo- synthesis. All drugs were screened for their anti-diabetic activity with the standard drug Acarbose by an in vitro alpha-amylation method. The compounds C1 and C3 have been shown to have significant anti-diabetic activity.
Cite this article:
Amol S. Dighe, Ashim K. Sen. Synthesis and Evaluation of some Novel Triazolo-thiadizoles Derivatives as Anti-diabetic Activity. Research Journal of Pharmacy and Technology 2023; 16(1):1-7. doi: 10.52711/0974-360X.2023.00001
Cite(Electronic):
Amol S. Dighe, Ashim K. Sen. Synthesis and Evaluation of some Novel Triazolo-thiadizoles Derivatives as Anti-diabetic Activity. Research Journal of Pharmacy and Technology 2023; 16(1):1-7. doi: 10.52711/0974-360X.2023.00001 Available on: https://rjptonline.org/AbstractView.aspx?PID=2023-16-1-1
REFERENCES:
1. Winter CA, Risley EA, Nuss GN. Carrageenan-induced edema in the hind paw of mice as an assay for anti-inflammatory drugs. Proscock Exp Biol. 1962; 86 (111); 544–47.
2. Vivona N, Busemi S, Esta S, Carona T. Photo induced molecular rearrangement. Photochemistry of 1,2,4-oxadizoles in the presence of sulfur nucleophiles. Synthesis of 1,2,4-thiadizole. Tetrahedron. 1997; 53: 12,629.
3. Cho NS, Sean HI, Parkainyi C Synthesis of 5-amino-1,2,4-thiadiazole-3-one. Journal of Heterocyclic. 1991; 28: 1645.
4. Mameva EA, Bakibaev AA. The oxidative azacylation of 1-monosubstised thiores in reaction with [bis (axyloxy) iodo] produces 1,2,4-thiadiazole derivatives. Tetrahedron. 2003; 59: 7521
5. Turner S, Mayer M. Antihypertensive thiadiazole. 1. Synthesis of some 2-aryl-5-hydrazino-1,3,4-thiadizoles with vasodilator activity. J of Med Che. 1988; 31: 902
6. Shehri MF, Abu-Hashem AA, El-Telbani EM. Synthesis of 3 - ((2,4-dichlorophenoxy methyl) -1,2,4-triazolo (thiadiazoles and thiadiazines) as anti-inflammatory and molluscicidal agents. European J of Med Chem. 2010; 45: 1906–1911.
7. Elias G, Rao M N A. Dehydration activity and its analogs of albumin erosion and anti-dehydration activity. Indian J. Exp. Biol. 1988; 26: 540.
8. Leeson P.D., Springthorpe B. The influence of drug-like concepts on decision-making in medicinal chemistry. Nat. Rev. Drug Discov. 2007; 6: 881-890.
9. Lipinski C.A., Lombardo F., Dominy B.W., Feeney P.J. Experimental and computational approaches to estimate solubility and permeability in drug discovery and development settings. Adv. Drug. Deliv. Rev. 1997; 23: 3-25.
10. Mohan H. Textbook of Pathology Jaypee Brothers Medical Publishers Limited. 2000;114–60.
11. Furniss B.S., Hanford A. J., Smith P. W. J. and Pathel A. R.Vogel's Text Book of Practical Organic Chemistry, ELBS Publications Private Limited. 2007; 5: 229: 1260
12. Alagarasamy V. Textbook of Medicinal Chemistry, Volume I, Elsevier Publications. 2010; 204–206.