Author(s): Aprilita Rina Yanti Eff, Reza Ayu Pertiwi, Maharani Hestu Muktiwisesa, Annisah Nurziah Sujadi

Email(s): aprilita.rinayanti@esaunggul.ac.id

DOI: 10.52711/0974-360X.2022.00708   

Address: Aprilita Rina Yanti Eff1, Reza Ayu Pertiwi2, Maharani Hestu Muktiwisesa2, Annisah Nurziah Sujadi2
1Department of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, West Jakarta, 11510, Indonesia.
2Bachelor Program in Departement of Pharmacy, Faculty of Health Sciences, Universitas Esa Unggul, West Jakarta, 11510, Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 9,     Year - 2022


ABSTRACT:
Hypertension in people with diabetes causes accelerated complications of the heart and kidneys. Angiotensin Converting Enzyme (ACE) inhibitors are the first choice managing of hypertension in patients with diabetes mellitus. Herbal medicine is a native Indonesian treatment that has been used since time immemorial to overcome various diseases, including hypertension and diabetes mellitus. This study aims to standardize and assay the in vitro ACE inhibitor, antidiabetic, and antioxidant activities on Indonesian medicinal plants (jamu). Methods: Jamu was extracted by maceration using ethanol. Standardization includes non-specific and specific parameters. The activity of angiotensin-converting enzyme inhibitor, alpha-glucosidase enzyme inhibiting activity, and antioxidant activity using a spectrophotometer. The results showed that jamu met the requirements of both specific and non-specific parameters, had angiotensin-converting enzyme inhibitors, alpha-glucosidase enzyme inhibitors, and antioxidants activity with IC50 values 103.75 µg/ml, 49.95 µg/ml, and 11.4 µg/ml. Conclusion: jamu meets the requirements according to the Indonesian Herbal Pharmacopoeia standards and has antihypertensive, antidiabetic, and antioxidant activities.


Cite this article:
Aprilita Rina Yanti Eff, Reza Ayu Pertiwi, Maharani Hestu Muktiwisesa, Annisah Nurziah Sujadi. In vitro assay of ACE Inhibitor, Antidiabetic and Antioxidants activities from Indonesia Traditional Medicine (Jamu). Research Journal of Pharmacy and Technology. 2022; 15(9):4212-7. doi: 10.52711/0974-360X.2022.00708

Cite(Electronic):
Aprilita Rina Yanti Eff, Reza Ayu Pertiwi, Maharani Hestu Muktiwisesa, Annisah Nurziah Sujadi. In vitro assay of ACE Inhibitor, Antidiabetic and Antioxidants activities from Indonesia Traditional Medicine (Jamu). Research Journal of Pharmacy and Technology. 2022; 15(9):4212-7. doi: 10.52711/0974-360X.2022.00708   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-9-68


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