Marina G D’Souza, D. Ramu, E. Haritha Reddy, Ravali Billa, N. Sai Kumar, Swathi B
Marina G D’Souza1*, D. Ramu2, E. Haritha Reddy2, Ravali Billa2, N. Sai Kumar2, Swathi B2
1Department of Pharmacognosy, Bharat Institute of Technology, Mangalpally, Hyderabad.
2Department of Pharm D, Bharat School of Pharmacy, Mangalpally, Hyderabad.
Volume - 15,
Issue - 9,
Year - 2022
Background: Osteoarthritis is a degenerative disorder commonly affecting any joints mostly joints of hands, knees, spine and hips. The disorder occurs when wear and tear of the protective layer of cartilage cushioning the ends of the bones occurs. The symptoms start with pain and stiffness the joints slowly leading to stiffness, tenderness, loss of flexibility, grating sensation, swelling and formation of bone spurs. Osteoarthritis causes deterioration of connective tissue and inflammation of the joint lining. Glucosamine sulphate found in the human body is a naturally occurring chemical which is especially present in the fluid around the joints and is involved in building ligaments cartilage and thick fluid that surrounds the joints. Sulphate part is important for building the cartilage. Sulfasalazine is anti-inflammatory drug and is used to treat and reduce inflammation. In this study the combination of glucosamine sulphate and sulfasalazine is used in combination to test the efficacy in reduction of inflammation and pain in comparison with sulfasalazine alone. Materials and Methods: In this prospective randomized controlled study 60 patients of osteoarthritites between the age group of 18 to 60 years were selected. Patients were divided into two groups (A and B). Age, severity of the disease was taken into consideration while grouping the patients. Group A was treated with Sulfasalazine alone 500mg once a day and group B with combination of Glucosamine Sulphate (oral) 750mg twice a day and Sulfasalazine (oral) 500mg once a day. Assessments of number of swollen joints and VAS and faces pain rating (scale) were carried out once in a month. Results: After six months 67% reduction in number of swollen joints and 76% of duration of morning stiffness in combination therapy was observed compared to 54% and 65% of reduction respectively in sulfasalazine alone. VAS score after six months was found to be 1 in combination therapy and 3 in suflasalazine alone. Conclusion: The study concluded that the combination treatment regimen glucosamine sulfate and oral sulfasalazine improved patient mobility, decreased number of swollen joints and decreased arthritic pain gradually.
Cite this article:
Marina G D’Souza, D. Ramu, E. Haritha Reddy, Ravali Billa, N. Sai Kumar, Swathi B. Efficacy of Oral Glucosamine Sulphate and Sulfasalazine combination in the treatment of Osteoarthritis. Research Journal of Pharmacy and Technology. 2022; 15(9):4208-1. doi: 10.52711/0974-360X.2022.00707
Marina G D’Souza, D. Ramu, E. Haritha Reddy, Ravali Billa, N. Sai Kumar, Swathi B. Efficacy of Oral Glucosamine Sulphate and Sulfasalazine combination in the treatment of Osteoarthritis. Research Journal of Pharmacy and Technology. 2022; 15(9):4208-1. doi: 10.52711/0974-360X.2022.00707 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-9-67
1. Kloppenburg M and F.Berenbaum, Osteoarthritis year in review 2019: epidemiology and therapy. Osteoarthritis and Cartilage. 2020;28(3):242-248. doi: 10.1016/j.joca.2020.01.002.
2. Tiku ML, Sabaawy HE. Cartilage regeneration for treatment of osteoarthritis: a paradigm for nonsurgical intervention. Ther Adv Musculoskelet Dis. 2015;7(3):76-87. doi:10.1177/1759720X15576866
3. Bruyère, Olivier & Altman, Roy & Reginster, Jean-Yves.. Efficacy and Safety of Glucosamine Sulfate in the Management of Osteoarthritis: Evidence from Real-Life Setting Trials and Surveys. Seminars in Arthritis and Rheumatism. 2016:45. 10.1016/j.semarthrit.2015.11.011. DOI: 10.1016/j.semarthrit.2015.11.011
4. Rains CP, Noble S, Faulds D. Sulfasalazine. A review of its pharmacological properties and therapeutic efficacy in the treatment of rheumatoid arthritis. Drugs. 1995;50(1):137-156. DOI: 10.2165/00003495-199550010-00009
5. MC Caffery, Margo RN, Faan MS, Choosing a faces pain scale. Nursing. 2002:32(5):68. doi: 10.1097/00152193-200205000-00064
6. H. Breivik, P. C. Borchgrevink, S. M. Allen, L. A. Rosseland, L. Romundstad, E. K. Breivik Hals, G. Kvarstein, A. Stubhaug, Assessment of pain, BJA: British Journal of Anaesthesia, 2008;101( 1): 17–24. https://doi.org/10.1093/bja/aen103
7. Stack RJ, Sahni M, Mallen CD, Raza K. Symptom complexes at the earliest phases of rheumatoid arthritis: a synthesis of the qualitative literature. Arthritis Care Res (Hoboken). 2013;65(12):1916-1926. doi:10.1002/acr.22097
8. Vasiliadis HS, Tsikopoulos K. Glucosamine and chondroitin for the treatment of osteoarthritis. World J Orthop. 2017;8(1):1-11. DOI: 10.5312/wjo.v8.i1.1
9. Steinmeyer J, Bock F, Stöve J, Jerosch J, Flechtenmacher J. Pharmacological treatment of knee osteoarthritis: Special considerations of the new German guideline. Orthop Rev (Pavia). 2018;10(4):7782. doi: 10.4081/or.2018.7782
10. Plosker, Greg & Croom, Katherine. (2005). Sulfasalazine: a review of its use in the management of rheumatoid arthritis. Drugs. 65. 1825-49.Seo Yeong-Mi, Won Hee Choi, Tae Kyung Kim. Factors affecting The Pain of Osteoarthritis Patients. Research J. Pharm. and Tech 2019; 12(2):699-705. DOI: 10.5958/0974-360X.2019.00124.0
11. Liudmila Lobuteva, Dmitrii Babaskin, Tatyana Degtyarevskaya, Tatyana Sakharova. Comparative effects of non-steroidal anti-inflammatory drugs in patients with osteochondrosis. Research J. Pharm. and Tech 2020; 13(2):589-592. DOI: 10.5958/0974-360X.2020.00111.0
12. Kamath M. Comprehensive method of managing Osteoarthritis in line with Complementary and alternative Medicine – A Review. Research J. Pharm. and Tech. 2020; 13(10):5009-5011. DOI: 10.5958/0974-360X.2020.00877.X
13. Liudmila Lobuteva, Dmitrii Babaskin, Tatyana Degtyarevskaya, Tatyana Sakharova. Comparative effects of non-steroidal anti-inflammatory drugs in patients with osteochondrosis. Research J. Pharm. and Tech 2020; 13(2):589-592. DOI: 10.5958/0974-360X.2020.00111.0
14. Sowmya. M.V, Shaik Chandbee, Rahul Dev. Influence of closed Kinematic chain exercise versus open Kinematic Chain Exercise on Q-Angle in subjects with Osteoarthritis Knee. Research J. Pharm. and Tech. 2020; 13(4):1813-1816. DOI: 10.5958/0974-360X.2020.00326.1
15. Sowmya M. V, Mangayarkarasi. M. Effect of Physiotherapy Intervention after Platelet Rich Plasma Procedure in Subjects with Grade 3 Osteoarthritis Knee. Research J. Pharm. and Tech 2020; 13(5):2065-2068. DOI: 10.5958/0974-360X.2020.00371.6
16. Sowmya MV, Rahul Dev. A Study to find the Influence of Hamstring strengthening on prevention of Osteoarthritis Knee from Mild to Moderate. Research J. Pharm. and Tech 2020; 13(3):1092-1094. DOI: 10.5958/0974-360X.2020.00200.0
17. K. Sathiya, Mohan Kumar. Effectiveness of Myotherapy on pain among patients subjected to major Orthopaedic surgery at a Tertiary care Hospital. Research J. Pharm. and Tech. 2019; 12(11): 5399-5406. DOI: 10.5958/0974-360X.2019.00937.5
18. Naresh Bhaskar Raj, Soumendra Saha, Srilekha Saha, Hazliza Razali, Nur Yanti Haryana Othman, Mahadeva Rao US. Does Proprioception of knee improve after various forms of Training in Osteoarthritis of Knee?. Research J. Pharm. and Tech 2019; 12(9):4379-4386. DOI: 10.5958/0974-360X.2019.00753.4
19. Jibu George Varghese, Dilakshana S, Dilli Ganesh S, Varshini L. A Study to Analyze the effectiveness of Mobilization with movement in OA knee Dysfunction: A Quasi Experimental Study. Research J. Pharm. and Tech. 2019; 12(5):2279-2282. doi: 10.5958/0974-360X.2019.00380.9