Author(s): Mazumder Avijit, Kumar Naveen, Das Saumya, Yadav Kumar Shivam

Email(s): nk701741@gmail.com

DOI: 10.52711/0974-360X.2022.00696   

Address: Mazumder Avijit, Kumar Naveen*, Das Saumya, Yadav Kumar Shivam
Department of Pharmacology, Noida Institute of Engineering and Technology (Pharmacy Institute), Greater Noida, Uttar Pradesh, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 9,     Year - 2022


ABSTRACT:
Gastroesophageal reflux disease (GERD) is digestive disorder of oesophagus. Reflux of food damage oesophagus and cause oesophageal ulcer and erosion. The treatment strategy starts by giving natural formulation and synthetic drugs. A comparison based on In-vivo study was carried out to determine the therapeutic efficacy of herbal formulation using Amla and Honey in combination with Pantoprazole and Rebamipide for the treatment of GERD, The effects of all above mentioned medication was also checked on intestinal motility. In vitro studies were carried out to determine the antispasmodic activity of Amla and Honey in comparison to acetylcholine by isolated rat ileum. In pylorus ligation GERD model mono-therapy was performed by giving herbal formulation of Amla and Honey. In combination therapy Pantoprazole and Rebamipide, Amla, Honey with Pantoprazole and Rebamipide were given and their therapeutic efficacy was observed at the ends of 14 days. In charcoal meal motility test the distance travelled by charcoal in intestine was measured. At the end of study it was concluded that combination therapy have highest therapeutic efficacy in comparison to mono-therapy of natural combination of Amla and Honey against Pantoprazole and Rebamipide. In In-vitro antispasmodic activity Amla and Honey formulation decreased the contractility pattern in concentration dependent manner against acetylcholine. In charcoal meal motility test highest intestinal motility were observed in Amla and Honey and can be given in GERD for easily digestion of food from stomach.


Cite this article:
Mazumder Avijit, Kumar Naveen, Das Saumya, Yadav Kumar Shivam. A Comparative Study on Mono-therapy and Combination Therapy of Additive Drugs (Rebamipide and Pantoprazole) with Amla and Honey combination for the Treatment of Gastroesophageal Reflux Disease and Intestinal motility. Research Journal of Pharmacy and Technology. 2022; 15(9):4144-0. doi: 10.52711/0974-360X.2022.00696

Cite(Electronic):
Mazumder Avijit, Kumar Naveen, Das Saumya, Yadav Kumar Shivam. A Comparative Study on Mono-therapy and Combination Therapy of Additive Drugs (Rebamipide and Pantoprazole) with Amla and Honey combination for the Treatment of Gastroesophageal Reflux Disease and Intestinal motility. Research Journal of Pharmacy and Technology. 2022; 15(9):4144-0. doi: 10.52711/0974-360X.2022.00696   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-9-56


REFERENCES:
1.    Mittal R, Vaezi MF. Esophageal Motility Disorders and Gastroesophageal Reflux Disease. N Engl J Med. 2020; 383(20):1961-1972. doi: 10.1056/NEJMra2000328.
2.    Katz PO, Gerson LB, Vela MF Guidelines for the diagnosis and management of gastroesophageal reflux disease American Gastroenterology. 2013; 108 (3): 308-328.
3.    Pankaj Rakha, Raj Kumar, Supriya, Nidhi, Manju Nagpal, Gitika Arora. Gastroesophageal Reflux Disease: Pathophysiology and Treatments Available. Research J. Pharmacology and Pharmacodynamics. 2010; 2(2):160-164.
4.    Herregods TV, Bredenoord AJ, Smout AJ. Pathophysiology of gastroesophageal reflux disease: new understanding in a new era. Neurogastroenterol Motil. 2015; 27:1202–1213.
5.    Juveriya Fatima, Saniya Khan, Nuha Rasheed, Abdul Saleem Mohammad. Conceptual Importance of Acidifiers, Antacids and Cathartics for its Significance in Pharmaceuticals – A Brief Review. Asian J. Pharm. Tech. 2017; 7(2): 59-62. doi: 10.5958/2231-5713.2017.00009.5
6.    Dharmendra Rajput, Anuradha Verma, Azra Qureshi, Sonam Singh, Bhavana Yadav, Naveen Das Manikpuri, Sonal Daniel, Pelesh Kumar Sahu, B. Rajgopal, Shailendra Nayak, Jaideep Dewangan, Kamal Deo Sahu, D. K. Tripathi, Amit Alexander, Ajazuddin. Evaluation of Stability Parameters for Calcium Carbonate Antacid Suspension using Different Concentrations of Suspending Agents. Research J. Pharm. and Tech. 7(9): Sept. 2014 Page 999-1003.
7.    D.J. Mikami, K.M. Murayama. Physiology and pathogenesis of gastro esophageal reflux disease Surgery, American Gastroenterology, 2015 ;( 5):515-525.
8.    Freedberg DE, Kim LS, Yang YX. The risks and benefits of long-term use of proton pump inhibitors: expert review and best practice advice from the American Gastroenterological Association. Gastroenterology. 2017; 152(4):706–715.
9.    Scholten Theo. “Long-term management of gastroesophageal reflux disease with Pantoprazole.” Therapeutics and clinical risk management (2007):3(2) 231-43. doi:10.2147/tcrm.2007.3.2.231
10.    Eteraf-Oskouei T, Najafi M. Traditional and modern uses of natural honey in human diseases: a review. Iran J Basic Med Sci. 2013; 16(6):731-742.
11.    Jain PK, Das D, Pandey N, Jain P “Traditional Indian Herb Emblica Officinalis & Its Medicinal Importance”. Innovare Journal of Ayurvedic Sciences, 2016; 4(4):1-15.
12.    Li S, Huang M, Wu G, Huang W, Huang Z. Efficacy of Chinese Herbal Formula Sini Zuojin Decoction in Treating Gastroesophageal Reflux Disease: Clinical Evidence and Potential Mechanisms. Frontiers in Pharmacology,2020;76(11):1-20.doi:10.3389/fphar.2020.00076
13.    Mosaddegh M, Shirzad M, Minaii M. Ahmadian-Attari M. Jovārish-e Jālīnūs, the Herbal Treatment of Gastro-Oesophageal Reflux Disease in the History of Medicine. Journal of Research on History of Medicine, 2013; 2(2):67-76.
14.    MacFarlane B. Management of gastroesophageal reflux disease in adults: a pharmacist's perspective. Integr Pharm Res Pract. 2018 Jun 5; 7:41-52. doi: 10.2147/IPRP.S142932.
15.    Chuang TW, Chen SC, Chen KT. Current status of gastroesophageal reflux disease: diagnosis and treatment. Acta Gastroenterol Belg. 2017; 80(3):396-404.
16.    Dasaroju S, Gottumukkala KM. Current Trends in the Research of Emblica officinalis (Amla): A Pharmacological Perspective International Journal of Pharmaceutical Sciences Review and Research, 2014; 24(2):150-159
17.    Lanka S. A review on pharmacological, medicinal and ethno botanical important plant: phyllanthus emblica linn. (Syn. Emblica officinalis), World Journal of Pharmaceutical Research, 2018;7(4): 380-396
18.    Snehal SP, Goyal R.K. Emblica officinalis Geart. A Comprehensive Review on Phytochemistry, Pharmacology and Ethnomedicinal Uses, Research Journal of Medicinal Plant, 2012; 6(1):6-16, DOI:10.3923/rjmp.2012.6.16.
19.    Bhuvaneswari G., Hepshibha Kerubhamani. Mangala Gowri, P. Effects on Honey dates Amla mix on level of Fatigue on Iron Deficiency Anaemia among Adolescent Girls at Selected Setting. Research J. Pharm. and Tech 2018; 11(8): 3337-3340
20.    Hasan R, Islam N, Islam R. Phytochemistry, pharmacological activities and traditional uses of Emblica officinalis: A review. International Current Pharmaceutical Journal, (2016);5(2):14-21
21.    Rao PV, Krishnan KT, Salleh S, Gan SH, Biological and therapeutic effects of Honey produced by Honey bees and stingless bees: a comparative review, Revista Brasileira de Farmacognosia, (2016); 26(5):657-664.
22.    Oskouei TE, Najafi M “Traditional and modern uses of natural Honey in human diseases: a review.” Iranian journal of basic medical sciences (2013);16(6): 731-42
23.    Buelga S, Celestino and lez-Param G,"Chemical Composition of Honey", Bee Products Chemical and Biological Properties" Springer International Publishing (2017); 43—82
24.    R. Bright, G. L. Abisha Bel. Honey in the Management of Childhood Illnesses. Int. J. of Advances in Nur. Management. 2021; 9(1):94-98.
25.    Disha M Dhabarde, HV Shahare, SS Gedam, PK Bhoyar, RO Ganjiwale. Aging of Honey Enhances Its Antibacterial Activity. Research J. Pharm. and Tech. 2009; 2 (4): 872-873.
26.    Wissam Zam, Rim Harfouch, Salwa Bittar, Meray Sayegh. Antibacterial activity of various Syrian honey types against Pseudomonas aueruginosa. Res. J. Pharmacognosy and Phytochem. 2017; 9(2): 73-76. doi: 10.5958/0975-4385.2017.00013.9
27.    Samarghandian S, Farkhondeh T, Samini F. Honey and Health: A Review of Recent Clinical Research. Pharmacognosy Res. 2017; 9(2):121-127. doi:10.4103/0974-8490.204647
28.    Cianciosi D, Forbes-Hernández TY, Afrin S, et al. Phenolic Compounds in Honey and Their Associated Health Benefits: A Review. Molecules. 2018; 23(9):2322. doi:10.3390/molecules23092322
29.     Mandal MB and Mandal S. “Honey: its medicinal property and antibacterial activity.” Asian Pacific journal of tropical biomedicine 2011:1(2) 154-60. doi:10.1016/S2221-1691(11)60016-6
30.    S. Sneha Aishwarya, V. Gowri, D. Darling Chellathai. Honey a Therapeutic Trial in Osteosarcoma. Research J. Pharm. and Tech. 2019; 12(6): 2959-2962. doi: 10.5958/0974-360X.2019.00498.0
31.    Rout SK, Dutta S, Sengupta M, Das S. Evaluation and Comparison Study of Acetylcholine and Histamine on Isolated Chick, Rat, Guinea pig and Rabbit Ileum with Special Reference to PD2 Value in Pharmacology Practical. Research J. Pharm. and Tech. 4(5): 2011; 715-718.
32.    Bhutada P S, Mundhada Y, Jain K S, Nandakumar K. Isolated goat ileum preparation: An alternative to isolated ileum preparation from laboratory animals. Indian J Pharmacol 2006; 38:140-151.
33.    Mittelstadt SW, Hemenway CL, Spruell RD. Effects of fasting on evaluation of gastrointestinal transit with charcoal meal. J Pharmacol Toxicol Methods. 2005; 52(1):154-8. doi: 10.1016/j.vascn.2005.04.017.
34.    Noy, D et al. Vehicle selection in the gastro - intestinal transit screen. Journal of Pharmacological & Toxicological Methods 2009; 60: 229–230.
35.    Prior H, Ewart L, Bright J, Valentin JP. Refinement of the charcoal meal study by reduction of the fasting period. Altern Lab Anim.2012; 40(2):99-107.doi: 10.1177/026119291204000209.
36.    Saha JK, Xia J, Grondin JM, Engle SK, Jakubowski JA. Acute hyperglycemia induced by ketamine/xylazine anesthesia in rats: mechanisms and implications for preclinical models. Exp Biol. Med (Maywood). 2005; 230(10):777-784. Doi:10.1177/153537020523001012
37.    Monteiro KM, Spindola HM, Possenti A, Tinti S V. Characterization of a refinement of the “pylorus ligation” model of rat gastric ulceration resulting in “no pain” and a more specific pharmacological response. Journal of Pharmacological and Toxicological Methods. 2013; 67(2): 121–128. doi:10.1016/j.vascn.2012.09.002
38.    Siepmann J, Faisant N, Akiki J, Richard J, Benoit JP. Effect of the size of biodegradable microparticles on drug release: experiment and theory. Journal of Controlled Release.2004; 96(1):123–134. doi: 10.1016/j.jconrel.2004.01.011.
39.    Wissam Z, Reine D. Overview of the Probiotics’ role in gastrointestinal disorders. Research J. Pharm. and Tech. 2020; 13(11):5557-5561.
40.    Patel V. Formulation and evaluation of delayed release pantoprazole Tablets. Asian J. Res. Pharm. Sci. 2013; 3(2):95-106.

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