Author(s): Komal Jain, Chandana Majee

Email(s): komaljain5689@gmail.com

DOI: 10.52711/0974-360X.2022.00680   

Address: Komal Jain*, Chandana Majee
Department of Pharmaceutical Chemistry, NIET Institute of Pharmacy, Greater Noida, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 9,     Year - 2022


ABSTRACT:
The extensive of liver disease is increase the delight of natural products to treat hepatic diseases. This research aimed to evaluated the hepatoprotective activity of semi-synthetic derivative of andrographolide obtained from Andrographis paniculate (Acanthaceae) generally known as king of bitter. Andrographolide was isolated from the methanolic extract of Andrographis paniculata. In recently various derivative synthesized from andrographolide for pharmacological activity like anti-cancer, antibacterial, anti-diabetic, anti-feedant, anti-viral and so on. In this research 3,19(4-bromo benzylidene) andrographolide were derivatized from andrographolide and evaluate its hepatoprotective potentiality. In this compound 3-19(4-bromo benzylidene andrographolide showed comparatively solubility than andrographolide. In the in- vivo experiment, 3-19(4-bromo benzylidene) andrographolide showed significant hepatoprotective activity by reducing the level of bilirubin, SGOT, SGPT and transminases and histogram support the result. Experimental results showed that 3-19(4-bromo benzylidene derivative able to treat hepatic disease with low toxicity and improved efficacy.


Cite this article:
Komal Jain, Chandana Majee. Hepatoprotective Activity of Andrographolide and its Semi-Synthetic Derivatives. Research Journal of Pharmacy and Technology. 2022; 15(9):4055-0. doi: 10.52711/0974-360X.2022.00680

Cite(Electronic):
Komal Jain, Chandana Majee. Hepatoprotective Activity of Andrographolide and its Semi-Synthetic Derivatives. Research Journal of Pharmacy and Technology. 2022; 15(9):4055-0. doi: 10.52711/0974-360X.2022.00680   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-9-40


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