Author(s): Komal Jain, Chandana Majee


DOI: 10.52711/0974-360X.2022.00680   

Address: Komal Jain*, Chandana Majee
Department of Pharmaceutical Chemistry, NIET Institute of Pharmacy, Greater Noida, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 9,     Year - 2022

The extensive of liver disease is increase the delight of natural products to treat hepatic diseases. This research aimed to evaluated the hepatoprotective activity of semi-synthetic derivative of andrographolide obtained from Andrographis paniculate (Acanthaceae) generally known as king of bitter. Andrographolide was isolated from the methanolic extract of Andrographis paniculata. In recently various derivative synthesized from andrographolide for pharmacological activity like anti-cancer, antibacterial, anti-diabetic, anti-feedant, anti-viral and so on. In this research 3,19(4-bromo benzylidene) andrographolide were derivatized from andrographolide and evaluate its hepatoprotective potentiality. In this compound 3-19(4-bromo benzylidene andrographolide showed comparatively solubility than andrographolide. In the in- vivo experiment, 3-19(4-bromo benzylidene) andrographolide showed significant hepatoprotective activity by reducing the level of bilirubin, SGOT, SGPT and transminases and histogram support the result. Experimental results showed that 3-19(4-bromo benzylidene derivative able to treat hepatic disease with low toxicity and improved efficacy.

Cite this article:
Komal Jain, Chandana Majee. Hepatoprotective Activity of Andrographolide and its Semi-Synthetic Derivatives. Research Journal of Pharmacy and Technology. 2022; 15(9):4055-0. doi: 10.52711/0974-360X.2022.00680

Komal Jain, Chandana Majee. Hepatoprotective Activity of Andrographolide and its Semi-Synthetic Derivatives. Research Journal of Pharmacy and Technology. 2022; 15(9):4055-0. doi: 10.52711/0974-360X.2022.00680   Available on:

1.    S. Rajagopal, R. A. Kumar, D. S. Deevi, C. Satyanarayana, and R. Rajagopalan, “Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata,” Journal of Experimental Therapeutics and Oncology, vol. 3, no. 3, 2003 pp. 147–158.
2.    Visen, P.K.S., B. Shukla, G.K. Patnaik and B.N. Dhawan. 1993. Andrographolide protects rat hepatocytes against paracetamol-induced damage. J Ethnopharmacol 40: 131-136.
3.    Choudhury, B.R and M.K. Poddar. 1985. Andrographolide and Kalmegh (Andrographispaniculata).
4.    R. A. Kumar, K. Sridevi, N. Vijaya Kumar, S. Nanduri, and S. Rajagopal. Anticancer and immunostimulatory compounds from Andrographis paniculate.  Journal of Ethnopharmacology.  vol. 92, no. 2-3, pp. 291–295, 2004.
5.    Ahmad, M. and Asmawi, M.Z. (1993). Some pharmacological effects of aqueous extract of Andrographis paniculata Nees. The International Conference on the Use of Traditional Medicine and Other Natural Products in Health- Care. (Abstracts), pp. 122.
6.    Mascolo, N., Sharma, R., Jain, S.C. and Capasso, F. (1988). Ethnopharmacology of Calotropis procera flowers. Journal of Ethnopharmacology, 22: 211-221.
7.    Handa, S.S. and Sharma, A. Hepatoprotective activity of andrographolide from Andrographis paniculata against carbontetrachloride. Indian Journal of Medical Research, 92: 276-283.
8.    Oyagbemi, A.A. and Odetola, A.A. (2010). Hepatoprotective effects of ethanolic extract of Cnidoscolus aconitifolius on paracetamol –induced hepatic damage in rats. Pakistan Journal of Biological Sciences, 13(4). 164-169.
9.    Sridevi K, et al. Anticancer and immunostimulatory compounds from Andrographis paniculata. J Ethnopharmacol 2004;92(2-3):291–5.
10.    KakkarP, dasB, Viswanathan PN.A modifiedspectrophotometric assay of superoxide dismutase Ind J BiochemBiophys 1984;21:131-132.
11.    M.E. Rinella, Nonalcoholic fatty liver disease: a systematic review, J. Am. Med. Assoc. 313 (22) (2015) 2263–2273.
12.    B. Wang, C. Tang, C. Chan, R. Guo, C. Qian, W. Huang, Synthesis and preliminary antihyperlipidaemic activities evaluation of andrographolide derivatives, Med. Chem. 8 (2012) 293–298.
13.    Ahsan, R., Islam, M., Bulbul, J. I., Musaddik, A. and Haque, E. (2009). Hepatoprotective activity of Methanol extract of some medicinal plants against carbon tetrachloride-induced hepatotoxicity in rats. European Journal of Scientific Research, 37(2): 302-310.
14.    Chatterjee, T.K. (2000). Medicinal plants with hepatoprotective properties. In: Herbal options, 3ed. Calcuta Books and Allied Publishers Limited, pp.135-137.
15.    C. Aromdee, Modifications of andrographolide to increase some biological activ-ities: a patent review (2006–011), Expert Opin. Ther. Pat. 22 (2) (2012) 169–180.
16.    E. Rusu, G. Enache, M. Jinga, R. Dragut, R. Nan, H. Popescu, C. Parpala, C. Homentcovschi, M. Nitescu, M. Stoian, A. Costache, M. Posea, F. Rusu, V. Jinga, D. Mischianu, G. Radulian, Medical nutrition therapy in non-alcoholic fatty liver disease −a review of literature, J. Med. Life. 8 (3) (2015) 258–262.
17.    M.J. Armstrong, L.A. Adams, A. Canbay, W.K. Syn, Extrahepatic complications of nonalcoholic fatty liver disease, Hepatol 59 (3) (2014) 1174–1197.
18.    Vermeulen ,N.P.E. Bessems,J.G.MVan de Straat,R,1992.Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism based prevention. Drug Metab .Rev,24,367-407.
19.    C. Tang, G. Gu, B. Wang, X. Deng, X. Zhu, H. Qian, W. Huang, Design, synthesis, and biological evaluation of andrographolide derivatives as potent hepatoprotective agents, Chem. Biol. Drug Des. 83 (2014) 324–333.
20.    Handa SS, Sharma A. Hepatoprotective activity of andrographolide against galactosamine & paracetamol intoxication in rats. Indian J Med Res 1990; 92 : 284-92.
21.    Rang HP, Dale MM, Ritter JM, Moore PK. Harmful effects of drugs. In: Pharmacology, 5 ed. Churchill Livingstone. Edinburgh; 2003. p. 724-37.
22.    S. Pandeti, R. Sonkar, A. Shukla, G. Bhatia, N. Tadigoppula, Synthesis of new an-drographolide derivatives and evaluation of their antidyslipidemic: LDL-oxidation and antioxidant activity, Eur. J. Med. Chem. 69 (2013) 439–448.
23.    S. Reagan-Shaw, N. Minakshi, N. Ahmad, Dose translation from animal to human studies revisted, FASEB J. 22 (2007) 659–661.
24.    Choudhury BR, Poddar MK. Andrographolide and Kalmegh (Andrographis paniculata) extract: in vivo and in vitro effect on hepatic lipid peroxidation. Methods Find Exp Clin Pharmacol 1984; 6 : 481-5.

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