Author(s): Avneesh Awasthy, Om Prakash Agrawal

Email(s): om11agra85@gmail.com

DOI: 10.52711/0974-360X.2022.00665   

Address: Avneesh Awasthy, Om Prakash Agrawal
Department of Pharmaceutical Chemistry, Patel College of Pharmacy, Madhyanchal Professional University, Ratibad, Bhopal - 466001, Madhya Pradesh.
*Corresponding Author

Published In:   Volume - 15,      Issue - 9,     Year - 2022


ABSTRACT:
The ß-carboline alkaloids possess a wide diversity of important biochemical effects and pharmacological properties. A series of ß-carboline derivatives were synthesized from L-tryptophan through the Pictet-Spengler reaction and oxidation of K2Cr2O7 via sequential one-pot synthesis method. In vitro anti-bacterial, insecticidal, and cytotoxic activities of all synthesized compounds were investigated by the tablet diffusion, leaf disc, and MTT methods, respectively. Some of the compounds(1a, 1b, 1c and 1j) exhibited obvious anti-bacterial effects and some (1-3) had significant cytotoxic activities against tumor cells 3LL, MCF-7, BGC-823 and QGY-7701, with IC50 values of 7.79, 5.75, 3.53 and 4.02 µg/mL, respectively. No insecticidal activity against third stage instar larvae of Mythimnaseparata Walker were observed under the tested concentration.


Cite this article:
Avneesh Awasthy, Om Prakash Agrawal. Synthesis and Antimicrobial and Anticancer Activity of β-Carboline Analogues. Research Journal of Pharmacy and Technology. 2022; 15(9):3969-4. doi: 10.52711/0974-360X.2022.00665

Cite(Electronic):
Avneesh Awasthy, Om Prakash Agrawal. Synthesis and Antimicrobial and Anticancer Activity of β-Carboline Analogues. Research Journal of Pharmacy and Technology. 2022; 15(9):3969-4. doi: 10.52711/0974-360X.2022.00665   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-9-25


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