Author(s): Shahlaa Zuhair Abdul-Majeed, Monther Faisal Mahdi, Suhad Faisal Hatem Al-Mugdadi

Email(s): pha.sha91@gmail.com

DOI: 10.52711/0974-360X.2022.00566   

Address: Shahlaa Zuhair Abdul-Majeed1*, Monther Faisal Mahdi2, Suhad Faisal Hatem Al-Mugdadi3
1Phd Student, Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
2Department of Pharmaceutical Chemistry, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
3Department of Clinical Laboratory Sciences, College of Pharmacy, Mustansiriyah University, Baghdad, Iraq.
*Corresponding Author

Published In:   Volume - 15,      Issue - 8,     Year - 2022


ABSTRACT:
To develop novel anti-inflammatory scaffolds, a new series of 4, 5-dihydro-1H- pyrazole-1-yl acetate derivatives synthesized through different chemical reactions and validated employing spectral and elemental data. To examine the interactions of these derivatives, which are thought to have anti-inflammatory effects, with cyclooxygenase-2 (COX-2) enzyme, docking studies were carried out on this enzyme. COX-2 enzyme (3LN1) was selected from the protein data bank for docking studies. The molecular docking study was applied by using Glide docking tool under Schrodinger (Maestro 11.1) software (Schrodinger, 2017). As a result of the docking process on COX-2 enzymes, the 4, 5-dihydro-1H-pyrazole ring was found to be important in its interactions with the COX-2 enzyme. The inclusion of a bulky group in the construct may eliminate some interactions with the COX-2 enzyme. To better elucidate the inhibition properties of enzymes, this study should be supported by in vitro and in vivo COX inhibition tests.


Cite this article:
Shahlaa Zuhair Abdul-Majeed, Monther Faisal Mahdi, Suhad Faisal Hatem Al-Mugdadi. Design, Molecular Docking Studies, Synthesis and Characterization of some New 4,5-dihydro-1H- Pyrazole-1-yl acetate Derivatives as Cyclooxygenase Inhibitors. Research Journal of Pharmacy and Technology. 2022; 15(8):3382-0. doi: 10.52711/0974-360X.2022.00566

Cite(Electronic):
Shahlaa Zuhair Abdul-Majeed, Monther Faisal Mahdi, Suhad Faisal Hatem Al-Mugdadi. Design, Molecular Docking Studies, Synthesis and Characterization of some New 4,5-dihydro-1H- Pyrazole-1-yl acetate Derivatives as Cyclooxygenase Inhibitors. Research Journal of Pharmacy and Technology. 2022; 15(8):3382-0. doi: 10.52711/0974-360X.2022.00566   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-8-8


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