Author(s): Chetan Hasmukh Mehta, Poojary Pooja Srinivas, Anusha SB, Kirollos Bahaa Fathy Mahany, KB Koteshwara, Usha Yogendra Nayak

Email(s): usha.nayak@manipal.edu

DOI: 10.52711/0974-360X.2022.00622   

Address: Chetan Hasmukh Mehta1, Poojary Pooja Srinivas1, Anusha SB1, Kirollos Bahaa Fathy Mahany2, KB Koteshwara1, Usha Yogendra Nayak1*
1Department of Pharmaceutics, Manipal College of Pharmaceutical Sciences, Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
2Faculty of Pharmacy, Assiut University, Egypt.
*Corresponding Author

Published In:   Volume - 15,      Issue - 8,     Year - 2022


ABSTRACT:
The present study is aimed at the design and development of aceclofenac co-crystals. Co-crystallization is one of the important techniques which helps to enhance the aqueous solubility of drugs by modifying the crystal structure using incorporation of the co-former into the formulation.. In the present study, supramolecular synthon approach and computational grid scan methods were used for the co-former selection. The different co-formers such as oxalic acid (OA), succinic acid (SA), maleic acid (MA), and benzoic acid (BA) were used. Aceclofenac (ACF) co-crystals were prepared by solvent evaporation and dry grinding method. Based on the computational results and experimental saturation solubility studies, maleic acid was considered as the suitable co-former for the preparation. The solid-state characterization showed partial conversion of ACF crystallinity to the amorphization as evident from the decrease in peak intensity and the number of peaks. The co-crystals showed increased aqueous solubility of ACF and higher drug release in basic pH. All the characterization parameters proved the co-crystal formation and the in vitro release studies showed that the solubility enhancement of the ACF by preparing ACF-MA co-crystals. Thus, it can be concluded that co-crystallization is one of the novel method for improving the bioavailability of aceclofenac.


Cite this article:
Chetan Hasmukh Mehta, Poojary Pooja Srinivas, Anusha SB, Kirollos Bahaa Fathy Mahany, KB Koteshwara, Usha Yogendra Nayak. Computational and Experimental Insights in Design and Development of Aceclofenac Co-Crystals. Research Journal of Pharmacy and Technology. 2022; 15(8):3709-6. doi: 10.52711/0974-360X.2022.00622

Cite(Electronic):
Chetan Hasmukh Mehta, Poojary Pooja Srinivas, Anusha SB, Kirollos Bahaa Fathy Mahany, KB Koteshwara, Usha Yogendra Nayak. Computational and Experimental Insights in Design and Development of Aceclofenac Co-Crystals. Research Journal of Pharmacy and Technology. 2022; 15(8):3709-6. doi: 10.52711/0974-360X.2022.00622   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-8-64


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