Author(s): Roaa Alhamidi, Wehad Ibrahim


DOI: 10.52711/0974-360X.2022.00621   

Address: Roaa Alhamidi*, Wehad Ibrahim
Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, Tishreen University, Lattakia, Syria.
*Corresponding Author

Published In:   Volume - 15,      Issue - 8,     Year - 2022

Paracetamol (PAR) is widely used for pediatric and geriatric patients to treat pain and fever, but it has an extremely bitter taste which poses a challenge to be formulated into suitable oral dosage forms for these age categories. This study was aimed to prepare taste-masked paracetamol microcapsules by temperature-induced phase separation technique using ethylcellulose (EC) as a wall polymer and calcium carbonate (CaCO3) as a gastro-soluble pore former. The effect of drug/polymer ratio and proportions of calcium carbonate in the wall on microcapsules characteristics were studied. The taste masking efficiency was evaluated using an in vitro dissolution model simulating oral cavity conditions. The optimized formulation was characterized by FT-IR and SEM. Results show that the particle size and the drug release in 0.1 N HCl (pH 1.2) were dependent on the drug/polymer ratio and the proportion of calcium carbonate in the wall. FT-IR spectroscopy of PAR microcapsules showed no interaction between drug and polymer. The in vitro taste masking evaluation of microparticles F8 with a drug/polymer ratio (8/1), which achieved the percent drug release more than 75% at 30min in 0.1N HCL, showed efficient taste-masking of PAR compared to the bitterness threshold.

Cite this article:
Roaa Alhamidi, Wehad Ibrahim. Preparation and Evaluation of Taste Masked Paracetamol Microcapsules. Research Journal of Pharmacy and Technology. 2022; 15(8):3703-8. doi: 10.52711/0974-360X.2022.00621

Roaa Alhamidi, Wehad Ibrahim. Preparation and Evaluation of Taste Masked Paracetamol Microcapsules. Research Journal of Pharmacy and Technology. 2022; 15(8):3703-8. doi: 10.52711/0974-360X.2022.00621   Available on:

1.    Kharb, V., Saharan, V. A., Kharb, V., et al. Formulation and evaluation of lipid based taste masked granules of ondansetron HCl. European Journal of Pharmaceutical Sciences. 2014; 62:180-188.
2.    Pein, M., Preis, M., Eckert, C., et al. Taste-masking assessment of solid oral dosage forms–a critical review. International Journal of Pharmaceutics. 2014; 465(1-2):239-254. ‏
3.    Arima, H., Higashi, T., and Motoyama, K. Improvement of the bitter taste of drugs by complexation with cyclodextrins: applications, evaluations and mechanisms. Therapeutic Delivery. 2012; 3(5):633-644.
4.    Gupta, S. K., Kumar, B., and Sharma, P. K. Study on Taste Masking of Ranitidine HCl Using Ion Exchange Resin. Asian J. Pharm. Tech. 2013; 3(2):60-62.
5.    Ghanchi, S. D and Dhawale, S. C. Taste Masking Technologies of Pharmaceuticals. Research J. Pharm. and Tech. 2011; 4(10):1513-1518.
6.    Ayenew, Z., Puri, V., Kumar, L., et al. Trends in pharmaceutical taste masking technologies: a patent review. Recent Patents on Drug Delivery & Formulation. 2009; 3(1):26-39. ‏
7.    Qin, W., He, Y., Guo, Z., et al. Optimization of taste-masking on ibuprofen microspheres with selected structure features. Asian Journal of Pharmaceutical Sciences. 2019; 14(2):174-182. ‏
8.    Pagar, H. B., Shinde, U. P., Agrawal, Y. S., et al. Taste Masking: A Review. Research J. Pharm. and Tech. 2012; 5(2):152-157.
9.    Suzuki, H., Onishi, H., Takahashi, Y., et al. Development of oral acetaminophen chewable tablets with inhibited bitter taste. International Journal of Pharmaceutics. 2003; 251(1-2):123-132.
10.    Almurisi, S. H., Akkawi, M. E., Chatterjee, B., et al. Taste masking of paracetamol encapsulated in chitosan-coated alginate beads. Journal of Drug Delivery Science and Technology. 2020; 56:101520. ‏
11.    Shiino, K., Iwao, Y., Miyagishima, A., et al. Optimization of a novel wax matrix system using aminoalkyl methacrylate copolymer E and ethylcellulose to suppress the bitter taste of acetaminophen. International Journal of Pharmaceutics. 2010; 395(1-2):71-77. ‏
12.    El-Refaie, W. M., El-Massik, M. A., Abdallah, O. Y., et al. Khalafallah NM. Formulation and evaluation of taste-masked paracetamol-lipid sachets and chewable tablets. Journal of Pharmaceutical Investigation. 2014; 44(6):431-442.
13.    Akel, H., Madani, F., and Ibrahim, W. Preparation of Paracetamol Microcapsules by Complex Coacervation and Studying the effect of some Factors Influencing Microencapsulation Yield and Efficacy. Research J. Pharm. and Tech. 2017; 10(10):3271-3275.
14.    Pawar, P. B., Wagh, M. P., and Bhandare, S. N. Formulation and Evaluation of Taste Masked Fast Dissolving/ Disintegrating Tablets of Hydroxyzine Hydrochloride. Asian J. Pharm. Tech. 2014; 4(2):63-68.
15.    Faisal, W., Farag, F., Abdellatif, A. A., et al. Taste masking approaches for medicines. Current drug delivery. 2018; 15(2):167-185.
16.    Albertini, B., Passerini, N., González‐Rodríguez, M. L., et al. Characterization and taste-masking evaluation of acetaminophen granules: comparison between different preparation methods in a high-shear mixer. European Journal of Pharmaceutical Sciences. 2004; 21(2-3):295-303.
17.    Lam, P. L., and Gambari, R. Advanced progress of microencapsulation technologies: in vivo and in vitro models for studying oral and transdermal drug deliveries. Journal of Controlled Release. 2014; 178:25-45.
18.    Mali, S. D., Khochage, S. R., Nitalikar, M. M., et al. Microencapsulation: A Review. Research J. Pharm. and Tech. 2013; 6(9):954-961.
19.    Palva, R., Singh, S. K., Verma, P. R. P., et al. Controlled release Microcapsules for Oral Delivery of Aceclofenac: Formulation and Characterization. Research J. Pharm. and Tech. 2015; 8(3):251-258. ‏
20.    Lengyel, M., Kállai-Szabó, N., Antal, V., et al. Microparticles, microspheres, and microcapsules for advanced drug delivery. Scientia Pharmaceutica. 2019; 87(3):20. ‏
21.    Jyothi, N. V. N., Prasanna, P. M., Sakarkar, S. N., et al. Microencapsulation techniques, factors influencing encapsulation efficiency. Journal of Microencapsulation. 2010; 27(3):187-197.
22.    Douroumis, D. Practical approaches of taste masking technologies in oral solid forms. Expert Opinion on Drug Delivery. 2007; 4(4):417-426.  
23.    Gittings, S., Turnbull, N., Roberts, C. J., et al. Dissolution methodology for taste masked oral dosage forms. Journal of Controlled Release. 2014; 173:32-42.
24.    Murtaza, G. Ethylcellulose microparticles: A review. Acta Pol Pharm. 2012; 69(1):11-22.
25.    Wasilewska, K., and Winnicka, K. Ethylcellulose–a pharmaceutical excipient with multidirectional application in drug dosage forms development. Materials. 2019; 12(20):3386.
26.    Sarkar, K., Sadat, S. M. A., Islam, M. S., et al. Study of ethyl cellulose based sustained release microspheres of naproxen sodium. Dhaka University Journal of Pharmaceutical Sciences. 2011; 10(2):123-129. ‏‏
27.    Bhanja, S. B., Martha, S. K., Sahu, P. K., et al. Preparation and In-Vitro Evaluation of Nicardipine Hydrochloride Microcapsules. Research J. Pharm. and Tech. 2011; 4(11):1737-1741.
28.    Akiladevi, D., Elango, K., and Basak, S. Preparation and In Vitro Controlled Release Characteristics of Salbutamol Microcapsules by Coacervation Phase Separation Technique. Research J. Pharm. and Tech. 2011; 4(2):276-278.
29.    Rogers, T. L., and Wallick, D. Reviewing the use of ethylcellulose, methylcellulose and hypromellose in microencapsulation. Part 2: Techniques used to make microcapsules. Drug Development and Industrial Pharmacy. 2011; 37(11):1259-1271. ‏
30.    Drašković, M., Medarević, D., Aleksić, I., et al. In vitro and in vivo investigation of taste-masking effectiveness of Eudragit E PO as drug particle coating agent in orally disintegrating tablets. Drug Development and Industrial Pharmacy. 2017; 43(5):723-731.
31.    Maniruzzaman, M., Boateng, J. S., Bonnefille, M., et al. Taste masking of paracetamol by hot-melt extrusion: an in vitro and in vivo evaluation. European Journal of Pharmaceutics and Biopharmaceutics. 2012; 80(2):433-442. ‏
32.    Thi, T. H. H., Morel, S., Ayouni, F., et al. Development and evaluation of taste-masked drug for paediatric medicines–Application to acetaminophen. International journal of pharmaceutics. 2012; 434(1-2):235-242. ‏
33.    Sajeev, C., Vinay, G., Archna, R., et al. Oral controlled release formulation of diclofenac sodium by microencapsulation with ethyl cellulose. Journal of Microencapsulation. 2002; 19(6):753-760. ‏
34.    Alpar, H. O. and Walters, V. The prolongation of the in vitro dissolution of a soluble drug (phenethicillin potassium) by microencapsulation with ethyl cellulose. Journal of Pharmacy and Pharmacology. 1981; 33(1):419-422. ‏
35.    Chemtob, C., Chaumeil, J. C., and N'Dongo, M. Microencapsulation by ethylcellulose phase separation: microcapsule characteristics. International Journal of Pharmaceutics. 1986; 29(1):1-7.‏.
36.    Oh, D. M., and Lee, M. H. Characteristics of ethylcellulose microcapsules of sulfisoxazole. Archives of Pharmacal Research. 1982; 5(2):61-70.
37.    Jalsenjak, I., Nicolaidou, C. F., and Nixon, J. R. The in vitro dissolution of phenobarbitone sodium from ethyl cellulose microcapsules. Journal of Pharmacy and Pharmacology. 1976; 28(12):912-914.
38.    Shivhare, U. D., Darakh, V., Mathur, V. B., et al. Preparation and Evaluation of Metformin Hydrochloride Microcapsules. Research J. Pharm. and Tech. 2009; 2(3):559-562.
39.    Avachat, A. M., Bornare, P. N., and Dash, R. R. Sustained release microspheres of ropinirole hydrochloride: Effect of process parameters. Acta Pharmaceutica. 2011; 61(4):363-376. ‏‏
40.    Prasertmanakit, S., Praphairaksit, N., Chiangthong, W., et al. Ethyl cellulose microcapsules for protecting and controlled release of folic acid. AAPS Pharmscitech. 2009; 10(4):1104-1112. ‏
41.    Zaki Rizkalla, C. M., latif Aziz, R., and Ibrahim Soliman, I. Microencapsulation of hydroxyzine HCl by thermal phase separation: in vitro release enhancement and in vivo pharmacodynamic evaluation. Pharmaceutical Development and Technology. 2013; 18(1):196-209. ‏
42.    Mohamed-Ahmed, A. H., Soto, J., Ernest, T., et al. Non-human tools for the evaluation of bitter taste in the design and development of medicines: a systematic review. Drug Discovery Today. 2016; 21(7):1170-1180.‏

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