Author(s): Afshan Khan, Aisha Siddiqui, M. A Jafri, Divya Vohora, Mohd Asif

Email(s): afshankhan2490@gmail.com

DOI: 10.52711/0974-360X.2022.00616   

Address: Afshan Khan1, Aisha Siddiqui2*, M. A Jafri3, Divya Vohora4, Mohd Asif5
1,2,3,5Department of Ilmul Advia, School of Unani Medical Education and Research, Jamia Hamdard, New Delhi. India.
4Department of Pharmacy, School of Pharmaceutical Education and Research, Jamia Hamdard, New Delhi. India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 8,     Year - 2022


ABSTRACT:
Background: India is an opulent provenance of medicinal plants used therapeutically to treat various disorders including depression. The present study was designed to scrutinize the antidepressant activity of Sharbat Ahmad Shahi (SAS) in swiss albino mice. Methods: The antidepressant activity was studied in swiss albino mice using two behavioural paradigms i.e forced swimming test (FST) and tail suspension test (TST). Sharbat ahmad shahi (6ml/kg), hydroalcoholic and aqueous extract of the ingredients of SAS (0.34mg/kg and 0.64mg/kg) respectively, was used as test drugs, Flauxatine (20mg/kg) was used as a standard drug and vehicle was distilled water (10ml/kg), orally for 14 days. Results: SAS, hydroalcoholic and aqueous extract of the ingredients of SAS produced a significant antidepressant effect in both FST and TST as they reduced the immobility time. A significant reduction in TBARS and an increased in GSH levels were observed in brains of mice exposed to FST and TST. Conclusion: The present study propound that SAS, hydroalcoholic and aqueous extract of the ingredients of SAS possess an antidepressant like effect.


Cite this article:
Afshan Khan, Aisha Siddiqui, M. A Jafri, Divya Vohora, Mohd Asif. Pre-Clinical Evaluation of Antidepressant and Antioxidant Activities of a Renowned Polyherbal Formulation. Research Journal of Pharmacy and Technology. 2022; 15(8):3674-0. doi: 10.52711/0974-360X.2022.00616

Cite(Electronic):
Afshan Khan, Aisha Siddiqui, M. A Jafri, Divya Vohora, Mohd Asif. Pre-Clinical Evaluation of Antidepressant and Antioxidant Activities of a Renowned Polyherbal Formulation. Research Journal of Pharmacy and Technology. 2022; 15(8):3674-0. doi: 10.52711/0974-360X.2022.00616   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-8-58


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