Author(s): Rasmita Jena, Diptirani Rath, Monalisa Rout, Sovan Pattanaik, Durga Madhab Kar

Email(s): durgamadhabkar@soa.ac.in

DOI: 10.52711/0974-360X.2022.00563   

Address: Rasmita Jena1,2, Diptirani Rath1, Monalisa Rout1, Sovan Pattanaik1, Durga Madhab Kar1*
1Department of Pharmacology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan Deemed to be University, Bhubaneswar -751003, Odisha, India.
2School of Pharmacy and Life Sciences, Centurion University of Technology and Management, Odisha, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 8,     Year - 2022


ABSTRACT:
Bacopa monnieri and Convolvulus pluricaulis with the Panchagavya ghrita are expected to have better nootropic activity than the combination of Bacopa monnieri and Convolvulus pluricaulis. These marshy herbs are found throughout India having various medicinal importances like treatment of ulcer, epilepsy, memory improvement. The present study was focused on the exploration and assessment of memory and learning activity from the aqueous and methanol extract of Bacopa monnieri (Brahmi) and Convolvulus pluricaulis (Sankhapuspi) leaves with and without the Panchagavya ghrita (PGG) by performing different pharmacological screening models. The study of nootropic activity was performed by using different screening methods such as; phenobarbitone sodium-induced sleeping time, elevated plus maze, radial arm maze, actophotometer. Both methanol and aqueous extracts of Brahmi, Sankhapuspi with the combinations of Panchagavya ghrita showed a significant increase in memory and learning activity as compared to solvent control group where methanol extract containing combination exhibited better enhancement of memory learning activity in all experimental models as compared to aqueous extract. However, it is confirmed that herbs are having excellent activities in learning and memory when combined with Panchagavya ghrita.


Cite this article:
Rasmita Jena, Diptirani Rath, Monalisa Rout, Sovan Pattanaik, Durga Madhab Kar. Evaluation of Nootropic activity of Bacopa monnieri and Convolvulus pluricaulis herbs extracts with Panchagavya ghrita. Research Journal of Pharmacy and Technology. 2022; 15(8):3365-9. doi: 10.52711/0974-360X.2022.00563

Cite(Electronic):
Rasmita Jena, Diptirani Rath, Monalisa Rout, Sovan Pattanaik, Durga Madhab Kar. Evaluation of Nootropic activity of Bacopa monnieri and Convolvulus pluricaulis herbs extracts with Panchagavya ghrita. Research Journal of Pharmacy and Technology. 2022; 15(8):3365-9. doi: 10.52711/0974-360X.2022.00563   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-8-5


REFERENCES:
1.    V. Narayanswamy: Origin and development of Ayurveda. Ancient Science of life, 1981, 1, 1-7.
2.    Sandhya S, Vinod KR, Sravan K.: Herbs used for brains disorder, Hygeia. J. D. Med, 2010, 38-45.
3.    Athar H, Amit K, Harshika A, Dewasya P S, Khan R, Mani D.: Immunomodulatory and antioxidant activities of fresh juice extracts of Brahmi and Guduchi, Indian J. Tradit. Knowle., 2017, 16 (3), 498-505.
4.    Bala P. Medicine and Medicinal Policies in India, Social and Historical Perspectives, Lexington Books, Lanham, 2007, P-38.
5.    Younus M, Younus A, Shahbaz I.: Value of Ayurvedic medicinal plants as psychotherapeutic agents – A review, Intern. J. Innov. Sci. Engg. Tech., 2015, 2 (11), 144-148.
6.    http://health.economictimes.indiatimes.com
7.    S. L. Kanthamma, J. Kriszhnamurthi et al. Insilico approach of interaction studies in Bacopa monnieri compounds targeting multi-proteins for Alzheimer’s disease. Research J. Pharm. and Tech. 11(4): April 2018: 1522-1526.
8.    E. Komali, Ch. Venkataramaiah et al. Anticonvulsant effect of Bacopa monnieri extracts on catecholamine metabolism during PTZ-induced epilepsy in different brain regions of albino rats. Research J. Pharm. and Tech. 11(4): April 2018: 1592-1598.
9.    Meenashree, G. Kathiravan et al. Effect of plant hormones and media composition on browning and growth of   Bacopa monnieri callus cultures. Research J. Pharm. and Tech. 10(2): February 2017: 497-500.
10.    R. Shasmitha and S. Saravana Kumar. Dose dependent effect of Bacopa monnieri on stress included neural degeneration in CA-1 and CA-3 hippocampus region of rat. Research J. Pharm. and Tech. 12(5): May 2019: 2353-2355.
11.    Joshi R, Reeta K H, Sharma S K, Tripathi M, Gupta Y K.: Panchagavya ghrita, an Ayurvedic Formulation attenuates seizures, cognitive impairment and oxidative stress in pentylenetetrazole induced seizures in mice, Indian. J. Exp. Biol., 2015, 53 (7), 446-451.
12.    Gerhard Vogel H., Drug discovery and evaluation, Springer 2002, 2nd ed. 428.
13.    Jaya Preethi P., Padmini K. et al. Screening models for CNS stimulant drugs: A Review. Asian J. Pharm. Res. 2013; Vol. 3: Issue 3, Pg 151-155.
14.    Sutherland, R.J., and Hamilton, D.A.: Rodent spatial navigation: at the crossroads of cognition and movement, Neurosci. Biobehav. Rev., 2004, 28, 687–697.
15.    Jayanth P. C., P. K. Kar et al. Evaluation of nootropic activity potential of Krill oil in diazepam induced amnesic mice. Research Journal of Pharmacology and Pharmacodynamics. 8(3): July -September, 2016. 111-114.
16.    Yadav K D, Reddy K. R. C., and Kumar V.: Beneficial effect of Brahmi ghrita on learning and memory in normal rat, AYU., 2014 Jul-Sep, 35(3), 325–329.
17.    Sreenu Thalla, Jyothibasu Tammu et al. Nootropic activity of Ocimum gratissimum in Streptozotocin induced amnesia. Asian J. Research Chem. 5(12): Dec., 2012. 1437-1439.
18.    Shaila D, Santosh M K, Chandrakumar T, Rao I S.: Standardization study of ghritas, J. Chem., 2004, 1, 151-157.
19.    Sharma H, Zhang X, Dwivedi C.: The effect of ghee (clarified butter) on serum lipid levels and microsomal lipid peroxidation, AYU., 2010, 31, 134-140.
20.    K. Chauhan, P. Santwani et al. Evaluation of antidepressant activity of Ailanthus excelsa roxb. using mice as experimental animal. Research J. Pharmacology and Pharmacodynamics; 3(3): 2011; 102-104.
21.    Ashitha George, Manjusha et al. Phytochemical composition and antioxidant activities of various stem extracts of Bacopa monnieri Linn. Research J. Pharm. and Tech. 6(9): September 2013.1074-1080.
22.    A. Sandhya, K. S. Kumar et al. Phytochemical screening and in vivo nootropic evaluation of Carissa carandus Linn. roots. Research Journal of Pharmacognosy and Phytochemistry. 8(2): April- June, 2016.81-84.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available