Author(s): Yeamy Agustina Marpaung, Trimurni Abidin, Syafruddin Ilyas, Irwana Nainggolan, Basri A. Gani

Email(s): tri.murni@usu.ac.id and , basriunoe@unsyiah.ac.id

DOI: 10.52711/0974-360X.2022.00583   

Address: Yeamy Agustina Marpaung1, Trimurni Abidin1*, Syafruddin Ilyas2, Irwana Nainggolan3, Basri A. Gani4*
1Department of Dentistry Conservative, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.
2Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.
3Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Sumatera Utara, Indonesia.
4Department of Oral Biology, Faculty of Dentistry, Universitas Syiah Kuala, Darussalam, Banda Aceh, Aceh Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 8,     Year - 2022


ABSTRACT:
Pulpitis can cause sensitivity and trigger endodontic infections that threaten to lose dentin. Nacre and Biodentine were reported as a stimulator of TGF-ß1 expression to induce tertiary dentin formation. To evaluate the ability of Nacre and Biodentine in inducing the TGF-ß1 expression of tertiary dentin formation. Thirty male Wistar rats (Rattus Novregicus) were divided into three groups. Haemotoxylin and Eosin staining observed the dentinal bridge formation while TGF-ß1 expression was evaluated by immunohistochemistry. Quantitative data were obtained based on the staining score. Kruskal-Wallis tests were used for statistical analysis. Nacre contains Calcium (95.04%), Oxygen (4.96%), and Carbon (0%). The dentin bridge formed after induced by Nacre and Biodentine was significant (p<0.05). Biodentine is stronger in reducing dentin bridges than Nacre in the hard tissue formed of the initial dentinal bridge and complete dentin bridges. The Quantity level expression of TGF-ß1 of dentine is higher than that influenced by Biodentine compared to the Nacre of all score categories. They are significant among the treatment of 7 days, 14 days, and 30 days (p<0.05). Nacre and Biodentine can support the healing of reversible pulpitis of Rattus novregicus, which is indicated by an increase in TGF-ß1 expression in inducing the dentinal bridge formation of 7, 14, and 30 days.


Cite this article:
Yeamy Agustina Marpaung, Trimurni Abidin, Syafruddin Ilyas, Irwana Nainggolan, Basri A. Gani. Role of Nacre and Biodentine to Inducing the TGF-β1 in the Dentin Tertiary Formation on the Pulpitis Reversible of Rattus norvegicus. Research Journal of Pharmacy and Technology. 2022; 15(8):3479-4. doi: 10.52711/0974-360X.2022.00583

Cite(Electronic):
Yeamy Agustina Marpaung, Trimurni Abidin, Syafruddin Ilyas, Irwana Nainggolan, Basri A. Gani. Role of Nacre and Biodentine to Inducing the TGF-β1 in the Dentin Tertiary Formation on the Pulpitis Reversible of Rattus norvegicus. Research Journal of Pharmacy and Technology. 2022; 15(8):3479-4. doi: 10.52711/0974-360X.2022.00583   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-8-25


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