Author(s): Rusul Y. Hameed, Israa Nathir, Waleed K. Abdulsahib, Haider Abdulkareem Almashhadani

Email(s): H_R200690@yahoo.com

DOI: 10.52711/0974-360X.2022.00579   

Address: Rusul Y. Hameed1, Israa Nathir2, Waleed K. Abdulsahib3, Haider Abdulkareem Almashhadani4,5
1Al Hikma College University, Baghdad, Iraq.
2Department of Pharmacy, Al-Rasheed University College, Baghdad.Iraq.
3Pharmacology and Toxicology Department, College of Pharmacy, Al- Farahidi University, Baghdad, Iraq.
4Department of Dentistry, Al-Rasheed University College, Baghdad, Iraq.
5Department of Medical Laboratory Techniques, Dijlah University College, Baghdad, 10021, Iraq.
*Corresponding Author

Published In:   Volume - 15,      Issue - 8,     Year - 2022


ABSTRACT:
In this paper, investigates the biosynthesis of gold nanoparticles (AuNPs) by biochemical method using Myrtus communis leaves extract as reducing agent and Chloroauric acid (HAuCl4) as precursors. X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM) and FTIR were used in addition to UV-visible spectroscopy (UV) in order to characterize the AuNPs. The biosynthesized AuNPs exhibited inhibitory effects on alpha amylase and alkaline phosphatase in sera of patient with type 2 Diabetes Miletus and the sera of healthy control subjects; the inhibition percentage with alpha amylase was 72 % and 45 % for patient and control group respectively. Oral consent obtained from the most of patients and healthy subjects before them being under study. Biological activities were investigated against some bacteria species to exploit AuNPs potential. Kinetic studies of alpha amylase exanimated. The goal of this study is to synthesized gold nanoparticles using simple, economical and environmentally green method. This stage is more suited to large-scale manufacturing since it is speedy and removes the complex steps in other bio-based methods.


Cite this article:
Rusul Y. Hameed, Israa Nathir, Waleed K. Abdulsahib, Haider Abdulkareem Almashhadani. Study the effect of biosynthesized gold nanoparticles on the enzymatic activity of alpha-Amylase. Research Journal of Pharmacy and Technology. 2022; 15(8):3459-5. doi: 10.52711/0974-360X.2022.00579

Cite(Electronic):
Rusul Y. Hameed, Israa Nathir, Waleed K. Abdulsahib, Haider Abdulkareem Almashhadani. Study the effect of biosynthesized gold nanoparticles on the enzymatic activity of alpha-Amylase. Research Journal of Pharmacy and Technology. 2022; 15(8):3459-5. doi: 10.52711/0974-360X.2022.00579   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-8-21


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