R. Devi, M. Komala, B. Jayanthi
R. Devi1*, M. Komala2, B. Jayanthi1
1Department of Pharmacy, FEAT, Annamalai University, Chidambaram – 608002. Tamilnadu.
2School of Pharmaceutical Sciences, Vel’s Institute of Science, Technology and Advanced Studies, Pallavaram, Chennai – 600117.
Volume - 15,
Issue - 8,
Year - 2022
Aim: This study determine the consistency of Lamotrigine with various drug formulations using the testing procedures such as differential scanning calorimetry and Fourier Transform Infrared Mass spectrometry. Method: Possible strong interactions between the drug and excipients affect the molecular nature, stability, and bioavailability of drugs, affecting therapeutic efficacy and protection. To see if there was a connection, the FTIR spectrum and DSC thermograms of raw drug, excipients, or drug-excipient mixtures were evaluated. Results and Conclusion: The drug had not come into contact with the excipients, according to the facts. Either of the excipients were mostly found to be consistent with the medication and can be used in the production of novel formulations based on the results obtained from DSC and FTIR.
Cite this article:
R. Devi, M. Komala, B. Jayanthi. Studies on Drug Compatibility with different Pharmaceutical excipients in Nanoparticle Formulation. Research Journal of Pharmacy and Technology. 2022; 15(8):3443-6. doi: 10.52711/0974-360X.2022.00576
R. Devi, M. Komala, B. Jayanthi. Studies on Drug Compatibility with different Pharmaceutical excipients in Nanoparticle Formulation. Research Journal of Pharmacy and Technology. 2022; 15(8):3443-6. doi: 10.52711/0974-360X.2022.00576 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-8-18
1. Seema US. Nikita DG. Pradnya PS. Akshay BK. An Overview of Nanoparticles: Current Scenario. Research J. Pharm. and Tech 2021; 13(3):239-6. doi: 10.52711/0975-4377.2021.00040
2. Durgesh G. Raksha G. Deepak K. Anjana G. Steffy C. A Review on Chitosan Nanoparticle as a Drug delivery system. Asian J. Pharm. Res 2020; 10(4):299-306. https://doi.org/10.5958/2231-5691.2020.00051.9
3. Prashant SW. Kshirsagar MD. Design and Characterization of Solid Lipid Nanoparticle Based Transdermal Drug Delivery System. Asian J. Res. Pharm. Sci 2017; 7(2): 87-91. https://doi.org/10.5958/2231-5659.2017.00013.3
4. Sirisha. Praveena R. A Complete Review. Nanoparticles Targeting to Brain. Asian J. Res. Pharm. Sci. 2020; 10(3):199-203. https://doi.org/10.5958/2231-5659.2020.00038.7
5. Sumit K. Dinesh B. Influence of Sodium Alginate and Calcium Chloride on the Characteristics of Isoniazid Loaded Nanoparticles. Research J. Pharm. and Tech 2021; 14(1):389-396. https://doi.org/10.5958/0974-360X.2021.00071.8
6. Somasundaram I. Sathesh V. Preparation and evaluation of Pramipexole dihydrochloride loaded chitosan nanoparticles for brain-targeting. Research J. Pharm. and Tech 2017; 10(1): 245-251. https://doi.org/10.5958/0974-360X.2017.00051.8
7. Ajazuddin et al Development of Lamotrigine Solid Dispersion for the Formulation and Evaluation of Fast Dissolving Tablets. Research J. Pharm. and Tech 2018; 11(6): 2468-2472. https://doi.org/10.5958/0974-360X.2018.00455.9
8. Prannoy S. Lakshmi PK. Design and Optimization of Hydrodynamically balanced oral In-situ gel of Lamotrigine. Research J. Pharm. and Tech 2020; 13(10):4865-4870. https://doi.org/10.5958/0974-360X.2020.00856.2
9. Vinal A. Dharmendra R. Shailesh J. Vishal K. Naveen G. Formulation and Development of Lamotrigine Fast Dissolving Tablet by Enhancing its Solubility through Solid Dispersion. Research J. Pharm. and Tech 2021; 14(2):873-878. https://doi.org/10.5958/0974-360X.2021.00155.4
10. Aboul-Kheir A. Hanaa S. Magda M. Sharf MN. Spectrophotometric Estimation of Lamotrigine and Minoxidil in Bulk and Dosage Forms Research J. Pharm. and Tech. 2012; 5(5): 697-708.
11. Thumma S. Compatibility studies of promethazine hydrochloride with tablet excipients by means of thermal and non-thermal methods. Pharmazie 2009; 64(3): 183-189.
12. Marsac PJ. Theoretical and practical approaches for prediction of drug-polymer miscibility and solubility. Pharm. Res 2006; 23(10): 2417-2426. https://doi.org/10.1007/s11095-006-9063-9.
13. Stephenson GA. Characterization of the solid state: quantitative issues. Adv Drug Deliv Rev 2001; 48(1): 67-90. https://doi.org/10.1016/s0169-409x(01)00099-0
14. Pani N. Nath L. Acharya S. Bhuniya B. Application of DSC, IST, and FTIR study in the compatibility testing of nateglinide with different pharmaceutical excipients. J. Therm. Anal. Calorim 2012; 108(1): 219-226. https://doi.org/10.1007/s10973-011-1299-x
15. Mora. Differential scanning calorimetry as a screening technique in compatibility studies of DHEA extended release formulations. J. Pharm. Biomed. Anal 2006; 42(1): 3-10. https://doi.org/10.1016/j.jpba.2006.02.038
16. Serajuddin AT et al. Selection of solid dosage form composition through drug-excipient compatibility testing. J. Pharm. Sci 1999; 88(7): 696-704. https://doi.org/10.1021/js980434g
17. Morsi N. Ghorab D. Refai H. Teba H. Preparation and evaluation of alginate/chitosan nanodispersions for ocular delivery. International Journal of Pharmacy and Pharmaceutical Sciences 2015; 7(7):234-40.
18. Parveen S. Sahoo SK. Polymeric nanoparticles for cancer therapy. J Drug Targeting 2008; 16: 108-23. https://doi.org/10.1080/10611860701794353
19. Calvo P. Vila-Jato JL. Alonso M. Evaluation of cationic polymer-coated nanocapsules as ocular drug carriers. Int J Pharm 1997; 153:41-50. http://dx.doi.org/10.1016%2FS0378-5173(97)00083-5
20. Shah S. Pal A. Kaushik V. Devi S. Preparation and characterization of venlafaxine hydrochloride loaded chitosan nanoparticles and in vitro release of drug. J Appl Polym Sci 2009; 112:2876-87. https://doi.org/10.1002/app.29807