Author(s): Amol Shete, Pankaj Chothe, Rajendra Doijad, Sachin Sajane

Email(s): amol.shete@rediffmail.com

DOI: 10.52711/0974-360X.2022.00549   

Address: Amol Shete1*, Pankaj Chothe2, Rajendra Doijad1, Sachin Sajane3
1Department of Pharmaceutics, Krishna Institute of Pharmacy of Krishna Institute of Medical Sciences Deemed To Be University, Karad, - 415539, India.
2Research Group Department of Pharmaceutics and Quality Assurance, Shree Santkrupa College of Pharmacy, Ghogaon, Karad-415111, MS, India.
3Department of pharmacology, Annasaheb Dange College of pharmacy, Ashta, Maharashtra. India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 7,     Year - 2022


ABSTRACT:
The objectives of present investigation were to prepare and evaluate liquid crystalline gel, study the effect of water concentration on liquid crystalline phases, incorporate antifungal agent and itraconazole (ITZ) co-crystals into liquid crystalline vehicle. Liquid crystalline gel formulations were prepared by using glyceryl mono-oleate GMO, water and other excipients. The prepared gel formulations were evaluated for various parameters like rheological, in vitro drug diffusion and in vivo skin irritation test etc. Differential scanning calorimetric spectra of ITZ loaded gel showed higher transition peak temperature 96.71oC and ITZ loaded co-crystal gel showed 99.2oC and pH 6.8 and 6.5 respectively. Enhanced rate of diffusion was observed when gels were loaded with co-crystals. The prepared liquid crystalline gel formulations containing itraconazole and its co-crystals were found useful in a topical delivery with improvement for in vitro and in vivo performance.


Cite this article:
Amol Shete, Pankaj Chothe, Rajendra Doijad, Sachin Sajane. Formulation and In-vitro, In-vivo Evaluation of Itraconazole and Itraconazole Co-Crystals Loaded Glyceryl Monooleate Based Liquid Crystalline Gel. Research Journal of Pharmacy and Technology. 2022; 15(7):3273-9. doi: 10.52711/0974-360X.2022.00549

Cite(Electronic):
Amol Shete, Pankaj Chothe, Rajendra Doijad, Sachin Sajane. Formulation and In-vitro, In-vivo Evaluation of Itraconazole and Itraconazole Co-Crystals Loaded Glyceryl Monooleate Based Liquid Crystalline Gel. Research Journal of Pharmacy and Technology. 2022; 15(7):3273-9. doi: 10.52711/0974-360X.2022.00549   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-7-71


REFERENCES:
1.    Patrick T. Progress in liquid crystalline dispersions: Cubosomes. Current Opinion in Colloid & Interface Science. 2005; 10 (56):274-279.
2.    Namdeo A, Jain N. Liquid crystalline pharmacogel based enhanced transdermal delivery of propranolol hydrochloride. Journal of Controlled Release. 2002; 82 (2) :223-36.
3.    Chen Y, Lu Y, Zhong Y, Wang Q, Wu W, Gao S. Ocular delivery of cyclosporine A based on glycerylmonooleate/ poloxamer 407 liquid crystalline nanoparticles: preparation, characterization, in vitro corneal penetration and ocular irritation. Journal of Drug Target. 2012; 20 (10): 856–63.
4.    Westesen K, Bunjes H, Hammer G, Siekmann B. Novel colloidal drug delivery systems. PDA Journal of Pharmaceutical sciences and technology. 2001;55(4):240–247
5.    Mugheirbi NA, Tajber L. Mesophase and size manipulation of itraconazole liquid crystalline nanoparticles produced via quasi nanoemulsion precipitation. European Journal of  Pharmaceutics and Biopharmaceutics. 2015; 96:226-36.
6.    Heike B, Thomas R. Thermotropic liquid crystalline drugs. J Pharm Pharmacol 2005; 57: 807–816.
7.    Nesseem D. Formulation and evaluation of Itraconazole via liquid crystal for topical delivery system. J Pharmaceutical  Biomedical Analysis. 2001; 26(3):387-99.
8.    Cheney, Miranda L. The Role of Cocrystals in Solid-State Synthesis of Imides and the Development of Novel Crystalline Forms of Active Pharmaceutical Ingredients 2009. Graduate School Theses and Dissertations. Paper 3693.
9.    Shete As, Murthy SM, Korpale S, Yadav AV, Sajane SJ, Sakhare SS,  Doijad RC. Cocrystals of Itraconazole with Amino Acids: Screening, Synthesis, Solid State Characterization, In Vitro Drug Release and Antifungal Activity. Journal of Drug Delivery Science and Technology. 2015; 28: 46-55.
10.    Aytekin M, Gursoy RN, Ide S, Soylu EH, Hekimoglu S. Formulation and characterization of liquid crystal systems containing azelaic acid for topical delivery. Drug Development and Industrial Pharmacy.2013; 39(2):228-39.
11.    Mohamed MI, Abdelbary AA, Kandil SM, Mahmoud TM. Preparation and evaluation of optimized zolmitriptanniosomal emulgel. Drug Development and Industrial Pharmacy.2019; 28:1-11.
12.    Shah JC, Sadhale Y, Chilukur DM.  Cubic phase gels as drug delivery systems. Advanced drug Delivery Reviews. 2001; 47:229–250.
13.    Rizwan SB, Boyd BJ, Rades T, Hook S. Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opinion on  Drug Delivery.  2010; 7(10):1133-44.
14.    Lu J, Li YP, Wang J, Li Z, Rohani S, Ching CB. Pharmaceutical cocrystals: a comparison of sulfamerazine with sulfamethazine. Journal of Crystal Growth. 2011; 335:110–14.
15.    Choi JH, Lee HY, Kim J, Kim Y.C. Monoolein Cubic Phase Containing Hydrophobically Modified Poly (N-isopropylacrylamide). Journal of  Industrial  Engineering and  Chemistry. 2007; 3:380-386.
16.    Barakat NS. Evaluation of Glycofurol-Based Gel as a New Vehicle for Topical Application of Naproxen. AAPS Pharm Sci Tech. 2010; 3:1138-1146.
17.    Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic modeling on drug release from controlled drug delivery systems. Acta Polania Pharmaceutica.  2010; 67(3):217-23
18.    Kokare C. Pharmaceutical microbiology, principles and application. Nirali Prakashan, Pune.2005.
19.    Hata K, Kimura J, Miki H, Toyosawa T, Nakamura T, Katsu K. In Vitro and In Vivo Antifungal Activities of ER-30346, a Novel Oral Triazole with a Broad Antifungal Spectrum. Antimicrobial Agents Chemotherapy. 1996; 40(10):2237-42.
20.    Thapa RK, Baskaran R, Madheswaran T,  Kim JO, Yong CS, Yoo BK. In vitro release and skin permeation of tacrolimus from monoolein-based liquid crystalline nanoparticles. Journal of Drug Delivery Science and Technology. 2012; 22(6): 479-484.
21.    Holler S, Clandia V. Effect of selected fluorinated drug in a ringing gel on rheological behavior and skin permeation. European Journal of Pharmaceutics and Biopharmaceutics. 2007; 66(1):120-6.
22.    Madheswaran T, Baskaran R, Thapa RK, Rhyu JY, Choi HY, Kim JO, Yong CS, Yoo BK. Design and in vitro evaluation of finasteride-loaded liquid crystalline nanoparticles for topical delivery. AAPS Pharm Sci Tech. 2013; 14(1):45-52.
23.    Qin Z, Chen F, Chen D, Wang Y, Tan Y, Ban J. Transdermal permeability of triamcinolone acetonide lipid nanoparticles. International Journal of Nanomedicine. 2019; 8(14)2485-2495.  
24.    Gaikwad, D., N. Jadhav, Terminalia Arjuna Transdermal Matrix Formulation Containing Different Polymer Components Asian Journal of Pharmaceutical and Clinical Research.2019; 26: 266.
25.    Kulkarni, M., V. Hastak, S. Jadhav. Development and characterization of transdermal delivery system of doxazosinmesylate International Journal of Applied Pharmaceutics. 2019; 11: 43.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available