Author(s): Sadeel A. Shanshal, Ali Saleh Noori, Jaafar Atheer Ghazi, Abdullah Tahseen Dahham, Abdulrahman Samer Mohamed Saleh, Harith Kh. Al-Qazaz

Email(s): sadeelshanshal@uomosul.edu.iq

DOI: 10.52711/0974-360X.2022.00548   

Address: Sadeel A. Shanshal1*, Ali Saleh Noori2, Jaafar Atheer Ghazi2, Abdullah Tahseen Dahham2, Abdulrahman Samer Mohamed Saleh2, Harith Kh. Al-Qazaz1
1College of Pharmacy, University of Mosul, Mosul, Iraq.
2Nineveh Health Directorate, Mosul, Iraq.
*Corresponding Author

Published In:   Volume - 15,      Issue - 7,     Year - 2022


ABSTRACT:
Background: Peptic ulcer disease (PUD) is a serious chronic medical condition. It is considered one of the most common illnesses worldwide. PUD has its own impact on the patients’ quality of life (QOL). Objectives: This study aimed to assess the QOL in patients with peptic ulcer disease in Mosul city, Iraq. Methods: A cross sectional study was carried out among 385 patients in a public general hospital and 5 local pharmacies in Mosul city during the period from 10th May to 5th August 2021. Data collection was performed using a face-validated SF-12v2 questionnaire assessing the patients’ physical, mental, and overall health. All the data were subjected to descriptive and inferential analyses. Results: Overall, only 8.6% of the participants reported that their general health is poor. The majority (40.8% and 38.4%) stated that peptic ulcer disease has no or little impact on their moderate daily physical activity. Significant differences were found in the physical, mental and overall QOL scores with socio-demographic characteristics. Conclusion: Quality of life assessment indicated that there are some negative impacts in the patients’ daily life caused either by the patients’ environmental aspects or peptic ulcer related symptoms.


Cite this article:
Sadeel A. Shanshal, Ali Saleh Noori, Jaafar Atheer Ghazi, Abdullah Tahseen Dahham, Abdulrahman Samer Mohamed Saleh, Harith Kh. Al-Qazaz. Impact of peptic ulcer disease on the quality of life: A Cross Sectional Study. Research Journal of Pharmacy and Technology. 2022; 15(7):3267-2. doi: 10.52711/0974-360X.2022.00548

Cite(Electronic):
Sadeel A. Shanshal, Ali Saleh Noori, Jaafar Atheer Ghazi, Abdullah Tahseen Dahham, Abdulrahman Samer Mohamed Saleh, Harith Kh. Al-Qazaz. Impact of peptic ulcer disease on the quality of life: A Cross Sectional Study. Research Journal of Pharmacy and Technology. 2022; 15(7):3267-2. doi: 10.52711/0974-360X.2022.00548   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-7-70


REFERENCES:
1.    Cires MJ, Wong X, Carrasco-Pozo C, et al. The gastrointestinal tract as a key target organ for the health-promoting effects of dietary proanthocyanidins. Frontiers in Nutrition. 2017; 3 57.
2.    Nauta AJ, Engels F, Knippels LM, et al. Mechanisms of allergy and asthma. European Journal of Pharmacology. 2008; 585(2–3): 354–60.
3.    Vieira WA, Pretorius E. The impact of asthma on the gastrointestinal tract (GIT). Journal of Asthma and Allergy. 2010; 3 123–30.
4.    Ramanan D, Cadwell K. Intrinsic defense mechanisms of the intestinal epithelium. Cell Host and Microbe. 2016; 19(4): 434–41.
5.    Ramakrishnan K, Salinas RC. Peptic ulcer disease. American Family Physician. 2007; 76(7): 1005–12.
6.    Chan HL-Y, Wu JC-Y, Chan FK-L, et al. Is non-Helicobacter pylori, non-NSAID peptic ulcer a common cause of upper GI bleeding? A prospective study of 977 patients. Gastrointestinal Endoscopy. 2001; 53(4): 438–42.
7.    Ifeanyi OE, Sunday AG. Some haematological and biochemical parameters in peptic ulcer patients in umudike, Abia state, Nigeria. World J Pharm Pharm Sci. 2014; 3(4): 294–302.
8.    Mahurkar N, Sayeed Ul Hasan SM. Synergistic Antiulcer Effect of Melatonin and Esomeprazole Combination in Pylorus Ligation, Ethanol, Aspirin induced Peptic Ulcers. Asian Journal of Pharmaceutical Research. 2015; 5(1): 10–4.
9.    Yuan Y, Padol IT, Hunt RH. Peptic ulcer disease today. Nature Clinical Practice Gastroenterology and Hepatology. 2006; 3(2): 80–9.
10.    Farsakh NAA. Risk factors for duodenal ulcer disease. Saudi Medical Journal. 2002; 23(2): 168–72.
11.    Venkatesan H. Retrospective Analytical Case Series Study on the Acid Peptic Disorders treated with Homoeopathic Medications. Research Journal of Pharmacology and Pharmacodynamics. 2020; 12(2): 97–100.
12.    Huh CW, Kim B-W. Clinical significance of risk factors for asymptomatic peptic ulcer disease. Clinical Endoscopy. 2017; 50(6): 514–5.
13.    Milosavljevic T, Kostić-Milosavljević M, Jovanović I, et al. Complications of peptic ulcer disease. Digestive Diseases. 2011; 29(5): 491–3.
14.    Snowden FM. Emerging and reemerging diseases: a historical perspective. Immunological Reviews. 2008; 225(1): 9–26.
15.    Boparai V, Rajagopalan J, Triadafilopoulos G. Guide to the use of proton pump inhibitors in adult patients. Drugs. 2008; 68(7): 925–47.
16.    Tinker A. How to improve patient outcomes for chronic diseases and comorbidities. Health Catalyst. 2017;
17.    Eiser C, Morse R. A review of measures of quality of life for children with chronic illness. Archives of disease in childhood. 2001; 84(3): 205–11.
18.    Bala M, Kalia R, Kaur J, et al. Assessment of Quality of Life among Diabetic Patients Visiting Medical Out Patient Department at Selected Health Care Facilities at Punjab. International Journal of Advances in Nursing Management. 2017; 5(4): 327–30.
19.    Group W. The World Health Organization quality of life assessment (WHOQOL): position paper from the World Health Organization. Social Science and Medicine. 1995; 41(10): 1403–9.
20.    Tripathi N, Balai MK. A Study to assess the Quality of life among Persons living with Hypertension, Diabetes Mellitus and Arthritis in selected Village of Ludhiana, Punjab. International Journal of Nursing Education and Research. 2018; 6(4): 379–82.
21.    Connell J, O’Cathain A, Brazier J. Measuring quality of life in mental health: are we asking the right questions? Social Science and Medicine. 2014; 120: 12–20.
22.    Megari K. Quality of life in chronic disease patients. Health Psychology Research. 2013; 1(3): e27.
23.    Prabha SL. Assess the Quality of Life (QOL) of patients undergoing Haemodialysis in Vinayaka Mission Hospital, Salem, Tamilnadu. International Journal of Advances in Nursing Management. 2015; 3(3): 197–9.
24.    Geurink KV. Community Oral Health Practice for the Dental Hygienist-E-Book. (Elsevier Health Sciences, 2014).
25.    Batra K, Sharma S. A Descriptive Study to Assess the Quality of Life in ESRD (End Stage Renal Disease) Patients Undergoing Hemodialysis in Selected Hospital of Mohali, Punjab. International Journal of Nursing Education and Research. 2018; 6(1): 31–6.
26.    Baghery H, Memarian R, Alhani F. Evaluation of the effect of group counselling on post myocardial infarction patients: determined by an analysis of quality of life. Journal of Clinical Nursing. 2007; 16(2): 402–6.
27.    Selai CE, Trimble MR, Rossor MN, et al. Assessing quality of life in dementia: Preliminary psychometric testing of the Quality of Life Assessment Schedule (QOLAS). Neuropsychological Rehabilitation. 2001; 11(3–4): 219–43.
28.    Bullinger M, Quitmann J. Quality of life as patient-reported outcomes: principles of assessment. Dialogues in Clinical Neuroscience. 2014; 16(2): 137.
29.    Salyers MP, Bosworth HB, Swanson JW, et al. Reliability and validity of the SF-12 health survey among people with severe mental illness. Medical Care. 2000; 1141–50.
30.    Burdine JN, Felix MR, Abel AL, et al. The SF-12 as a population health measure: an exploratory examination of potential for application. Health Services Research. 2000; 35(4): 885.
31.    Lacson E, Xu J, Lin S-F, et al. A comparison of SF-36 and SF-12 composite scores and subsequent hospitalization and mortality risks in long-term dialysis patients. Clinical Journal of the American Society of Nephrology. 2010; 5(2): 252–60.
32.    Ware J, Kisinski M, Keller S. How to Score SF-12 Physical and Mental Health Summary Scales. (The Health Institute, New England Medical Center, 1995).
33.    Ware Jr JE, Kosinski M, Keller SD. A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Medical Care. 1996; 220–33.
34.    Chaney P. Wellness in the Urban Workplace: Strategies for Keeping Your Workforce Healthy. https://thebenefitsguide.com/ wellness-in-the-urban-workplace-strategies-for-keeping-your-workforce-healthy/ (2018).
35.    Galea S, Freudenberg N, Vlahov D. Cities and population health. Social science and medicine. 2005; 60(5): 1017–33.
36.    Conway P, Favet H, Hall L, et al. Rural health networks and care coordination: health care innovation in frontier communities to improve patient outcomes and reduce health care costs. Journal of Health Care for the Poor and Underserved. 2016; 27(4A): 91.
37.    Lee PN. The effect of reducing the number of cigarettes smoked on risk of lung cancer, COPD, cardiovascular disease and FEV1–A review. Regulatory Toxicology and Pharmacology. 2013; 67(3): 372–81.
38.    Godtfredsen NS, Prescott E. Benefits of smoking cessation with focus on cardiovascular and respiratory comorbidities. The Clinical Respiratory Journal. 2011; 5(4): 187–94.
39.    Mehta H, Nazzal K, Sadikot RT. Cigarette smoking and innate immunity. Inflammation Research. 2008; 57(11): 497–503.
40.    Qiu F, Liang C-L, Liu H, et al. Impacts of cigarette smoking on immune responsiveness: Up and down or upside down? Oncotarget. 2017; 8(1): 268.
41.    Rosenstock S, Jørgensen T, Bonnevie O, et al. Risk factors for peptic ulcer disease: a population based prospective cohort study comprising 2416 Danish Adults. Gut. 2003; 52(2): 186–93.
42.    Cheng Y, Macera CA, Davis DR, et al. Does physical activity reduce the risk of developing peptic ulcers? British Journal of Sports Medicine. 2000; 34(2): 116–21.
43.    Cheng Y, Macera CA, Davis DR, et al. Physical activity and peptic ulcers. Western Journal of Medicine. 2000; 173(2): 101.
44.    Shephard RJ. Peptic ulcer and exercise. Sports Medicine. 2017; 47(1): 33–40.
45.    Stephens MAC, Wand G. Stress and the HPA axis: Role of glucocorticoids in alcohol dependence. Alcohol Research: Current Reviews. 2012; 34(4): 468–83.
46.    Bartolomucci A, Leopardi R. Stress and depression: preclinical research and clinical implications. PloS One. 2009; 4(1): e4265.
47.    Gheena S. Cortisol in saliva of uncontrolled diabetes patients and Adrenal stress index. Research Journal of Pharmacy and Technology. 2016; 9(10): 1786–8.
48.    Brown ES, Varghese FP, McEwen BS. Association of depression with medical illness: does cortisol play a role? Biological Psychiatry. 2004; 55(1): 1–9.
49.    Di Mario F, Goni E. Gastric acid secretion: changes during a century. Best Practice and Research Clinical Gastroenterology. 2014; 28(6): 953–65.
50.    Hannibal KE, Bishop MD. Chronic stress, cortisol dysfunction, and pain: a psychoneuroendocrine rationale for stress management in pain rehabilitation. Physical Therapy. 2014; 94(12): 1816–25.
51.    Centers of Disease Control and Prevention (CDC). Mental Health Conditions: Depression and Anxiety. https://www.cdc.gov/ tobacco/campaign/tips/diseases/depression-anxiety.html.
52.    Saris IMJ, Aghajani M, van der Werff SJA, et al. Social functioning in patients with depressive and anxiety disorders. Acta Psychiatrica Scandinavica. 2017; 136(4): 352–61.
53.    Wensing M, Vingerhoets E, Grol R. Functional status, health problems, age and comorbidity in primary care patients. Quality of Life Research. 2001; 10(2): 141–8.
54.    Wen Z, Li X, Lu Q, et al. Health related quality of life in patients with chronic gastritis and peptic ulcer and factors with impact: a longitudinal study. BMC Gastroenterology. 2014; 14(1): 1–10.
55.    Rayyani M, Malekyan L, Forouzi MA, et al. Self-care self-efficacy and quality of life among patients receiving hemodialysis in South-East of Iran. Asian Journal of Nursing Education and Research. 2014; 4(2): 165–71.
56.    Pezzilli R, Morselli-Labate AM, Frulloni L, et al. The quality of life in patients with chronic pancreatitis evaluated using the SF-12 questionnaire: a comparative study with the SF-36 questionnaire. Digestive and Liver Disease. 2006; 38(2): 109–15.
57.    Apolone G, Mosconi P, Ware JE. Questionario sullo stato di salute SF-36: manuale d’uso e guida all’interpretazione dei risultati. (Guerini, 1997).
58.    Dasgupta P, Dubey K. Factors Affecting Stress Level of Married Working Women in Dual Income Family. Asian Journal of Management. 2015; 6(4): 265–75.
59.    Indra V. Health-Promoting Factors related to lifestyle among nursing students in University of Hail. Asian Journal of Nursing Education and Research. 2018; 8(4): 535–7.

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