Author(s): Dhamodharan S., Anima Nanda, B. K. Nayak

Email(s): animananda72@gmail.com

DOI: 10.52711/0974-360X.2022.00546   

Address: Dhamodharan S.1, Anima Nanda1*, B. K. Nayak2
1Department of Biomedical Engineering, Sathyabama Institute of Science and Tecchnology, Deemed to be University, Chennai - 600119, India.
2Department of Botany, Kanchi Mamunivar Govt. Institute for Postgraduate Studies and Research, Puducherry - 605008, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 7,     Year - 2022


ABSTRACT:
Antibacterial battle has appeared as one horrible problems giving a great assignment to pharmacological and medicinal segments around the globe. This gain in drug resistant microbes permits easy transmission of their resistant genes through a system of vulnerable bacteria ensuing in the advent of superbugs. Among resistance design exhibited by multidrug resistant bacteria, enzymatic worth of defense mechanism i.e., Extended Spectrum ß-lactamases (ESBL) continue as one of the active policy towards the broad spectrum drugs. Freshly, numerous articles testified the amplified occurrence of urinary tract infection because of ESBL creating Escherichia coli. There is no data are existing to date concerning patients bestowing with complex upper ESBL positive E. coli infections and sepsis. During the current study, pathogenic ESBL producing Escherichia coli isolates that cause UTI infections from dissimilar hospitals were noticed for their virulence gene employing Polymerase chain reaction, further they were examined for antibiotic sensitivity design against varied therapeutic drugs available in the market places. It was found that the antibiotic sensitivity was notably high for Carbapenems followed by Ofloxacin and Doxycycline hydrochloride. Moreover, least sensitivity was recorded for Cephalosporins. The present study found that UTI instigated by Pathogenic ESBL creating E. coli in nosocomial infections are to be the maximum among the persons with immunologically suppressed. Multidrug resistant E. coli can be readily come across in hospital conditions during daily medical practices and the urologist should act judiciously. The organization of such contagions is exceptionally significant for the future, with specific references to prevent new antibiotic resistance patterns.


Cite this article:
Dhamodharan S., Anima Nanda, B. K. Nayak. Extended spectrum of Beta-lactamase-positive Escherichia coli causing complicated Urinary Tract Infection and their resistance towards different Therapeutic drugs. Research Journal of Pharmacy and Technology. 2022; 15(7):3255-9. doi: 10.52711/0974-360X.2022.00546

Cite(Electronic):
Dhamodharan S., Anima Nanda, B. K. Nayak. Extended spectrum of Beta-lactamase-positive Escherichia coli causing complicated Urinary Tract Infection and their resistance towards different Therapeutic drugs. Research Journal of Pharmacy and Technology. 2022; 15(7):3255-9. doi: 10.52711/0974-360X.2022.00546   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-7-68


REFERENCES:
1.    Nanda A. and Saravanan M., Biosynthesis of silver nanoparticles from Staphylococcus aureus and its antimicrobial activity against MRSA and MRSE, Journal of Nanomedicine: Nanotechnology, biology and medicine, 2009; 5: 452–456.
2.    Drieux L., Brossier F., Sougakoff W., Jarlier. Phenotypic detection of extended-spectrum β-lactamase production in Enterobacteriaceae: review andbench guide. Clin Microbiol Infect; 14(Suppl. 1): 2008; 90-103.
3.    Kirby-Bauer W M, Sherris J C, Turck M. Antibiotic Susceptibility Testing by Single Disc Method. Am J Clin Pathol. 1966; 45:4
4.    Ali MH, Kalima P, Maxwell SRJ. Failure to implement hospital antimicrobial prescribing guidelines: a comparison of two UK academic centres. J Antimicrob Chemother2006; 57:959-62.
5.    Hogerzeil VH. Promoting rational prescribing: an international perspective. Br J Clin Pharmacol 1995;39:1-6.
6.    Kotwani A, Holloway K. Trend in antibiotic use among outpatient in New Dehli, India. BMC Infect Dis 2011; 11:99-107.
7.    Cerquetti, M., M. Giufre and A. Gareia-Fernandez,2010. Clin Microbid Infect., 16: 1555-1558.
8.    Rajesh Kondian Rangachari, Mathavi Suresh Kumar and Indra Priyadharsini. Detection of extended spectrum beta-lactamase producing gram negative bacilli in urinary isolates. Int.J. Biol. Med. Res. 2010; 1(4): 130-132.
9.    Livermore DM, Woodford N. The beta-lactamase threat in Enterobacteriaceae, Pseudomonas and Acinetobacter. Trends Microbiol. 2006;14(9):413-20.
10.    Ramphal R, Ambrose PG. Extended-spectrum beta-lactamases and clinical outcomes: current data. Clin Infect Dis. 2006 Apr 15;42 Suppl 4:S164-72.
11.    Amita Jain, Indranil Roy, Mahendra K.Gupta, Mala Kumar and S. K. Agarwal. Prevalence of extended spectrum lactamase producing Gram-negative bacteria in septicaemic neonates in a tertiary care hospital. J. Med. Microbiol. 2003. 52: 421 425.
12.    Anil Rajput, Bhavin Prajapati,.Bimal Chauhan, Atit Shah, Toral Trivedi, and Mina Kadam. Prevalence of Metallo-beta-lactamases (MBL) producing Pseudomonas aeruginosa in a Tertiary care Hospital. Indian. J. Basic. Appl. Med. Res. 2012; 1(4): 304-308.
13.    Sarikaya M, Tamerler C, Jen AK, Schulten K, Baneyx F: Molecular biomimetics: nanotechnology through biology. Nat Mater 2003; 2:577-585
14.    Philippon, A., Arlet, B. and Jacoby, G. A.  Plasmid-determined Amp C-type β–lactamases.  Antimicrobial Agents Chemotherapy, 2002; 46, 1-11.
15.    Rajesh Kondian Rangachari, Mathavi Suresh Kumar and Indra Priyadharsini. Detection of extended spectrum beta-lactamase producing gram negative bacilli in urinary isolates. Int. J. Biol. Med. Res.  2010; 1(4): 130-132.
16.    Dinesh, S. Chandel, Judith A. Johnson, Rama Chaudhry et al. Extended spectrum beta-lactamase-producing Gram-negative bacteria causing neonatal sepsis in India in rural and urban settings. J. Med. Microbiol. 2011; 60: 500 507.
17.    Mark E. Rupp and Paul D. Fey.  Extended spectrum beta-lactamase (ESBL)-Producing Enterobacteriaceae. Drugs. 2003; 63(4): 353-365.
18.    Hodiwala (bhesania), A., R. Dhoke, and A.D. Urhekar. Incidence of metallo-beta-lactamase producing Pseudomonas, Acinetobacter & enterobacterial isolates in hospitalised patients. Inter. J. Pharm. Biol. Sci.  2013; 3(1): 79-83.
19.    Nirav P. Pandya, Sweta B. Prajapati, Sanjay J. Mehta, Kunjan M. Kikani and Pratima J. Joshi. Evaluation of various methods for detection of metallo- lactamase (MBL) production in gram negative bacilli. Int. J. Biol. Med. Res. 2011; 2(3): 775-777.
20.    Okeke, I. N., Laxminarayan, R., Bhutta, Z.A., Duse, A. G., Jenkins, P., O’Brien, T. F. and Pablos-Mendez, A.  Antimicrobial resistance in developing countries.  Part I: Recent trends and current status.  Lancet Infectious Disease 2005; 5, 481-493.
21.    Carraminana, J. J., Rota, C., Agustin, I. and Herrera, A. (2004).  High prevalence of multiple resistance to antibiotics in Salmonella serovars isolated from poultry slaughter house in Spain.  Veterinary Microbiology 104, 133-139.
22.    Redondo-Lopez V, Cook RL, Sobel JD (1992). Emerging role of lactobacilli in the control and maintenance of the vaginal microflora. Rev. Infect. Dis.12: 856-872.
23.    Chang CE, Pavlova SI, Tao L, Kim EK, Kim SC, Yun HS, So JS (2002). Molecular identification of Vaginal Lactobacillus spp. isolated from Korean Women. J. Microbiol. Biotechnol. 12: 312-317.

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