Author(s): Rahul Vishvakarma, Arti Majumdar, Neelesh Malviya

Email(s): rahulvishvakarma5@gmail.com

DOI: 10.52711/0974-360X.2022.00540   

Address: Rahul Vishvakarma*, Arti Majumdar, Neelesh Malviya
Department of Pharmaceutics, Smriti College of Pharmaceutical Education, Indore - 452010 MP India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 7,     Year - 2022


ABSTRACT:
The motivation behind this investigation was to design novel drug delivery system containing orlistat micro sponges. Microsponges containing orlistat and Ethyl cellulose/ Eudragit RS 100 prepared by quasi emulsion solvent diffusion (Technique) method. The formulations were prepared step by step increases Drug: polymer ratio. The particle size (Malvern analyzer), Surface Morphology and structure examination (SEM) Production yield, Drug entrapment Efficiency and in vitro drug release studied of microsponges were examined. Shape or surface morphology and topography of the orlistat microsponges were examined by scanning electron microscopy. The drug orlistat disperse in GIT for better therapeutic effect as microsponges disperse freely in GIT. To improve absorption of orlistat so as to enhance bioavailability, micro sponges is used as delivery systems which show better absorption and bioavailability then other dosage form of orlistat. The particle size were prepared microsponges was observed in the range of 50.45 ± 0.85µm to 57.77 ± 1.35µm. The drug entrapment of the orlistat microsponges was observed in the range of 73.23 ± 0.23 to 83.41 ± 1.17 % The in vitro drug release study of the microsponges over 8 hour range from 59.28 ± 0.41% to 73.16 ± 0.89 %. The objective of this research work was to formulation and evaluation of orlistat loaded microsponges for management of obesity disease. Microsponges drug delivery system landscape have been highly and rapidly evolving. They are allowing for novel product form. Microsponges are safe biologically and extraordinary preferred position programmable release. This delivery system are being integrated to optimize the efficacy or free streaming effectiveness treatment.


Cite this article:
Rahul Vishvakarma, Arti Majumdar, Neelesh Malviya. Formulation and evaluation of orlistat loaded microsponges for the treatment of obesity. Research Journal of Pharmacy and Technology. 2022; 15(7):3221-5. doi: 10.52711/0974-360X.2022.00540

Cite(Electronic):
Rahul Vishvakarma, Arti Majumdar, Neelesh Malviya. Formulation and evaluation of orlistat loaded microsponges for the treatment of obesity. Research Journal of Pharmacy and Technology. 2022; 15(7):3221-5. doi: 10.52711/0974-360X.2022.00540   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-7-62


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