Author(s):
Maysoon Khudair. AL-Hadrawi, Ahmed Abdul Hasan Mohsin, Kais K.AL- Hadrawai, Noor Ismeal Nasser, Ali k. Metiab
Email(s):
kin.msn@atu.edu.iq
DOI:
10.52711/0974-360X.2022.00536 
Address:
Maysoon Khudair. AL-Hadrawi1, Ahmed Abdul Hasan Mohsin2, Kais K.AL- Hadrawai3, Noor Ismeal Nasser4, Ali k. Metiab
1Asisst. Prof, Department of Medical Laboratory Techniques, Kufa, Technical Institute, Al-Furat Al-Awsat Technical University31001, Kufa, Al-Najaf, Iraq.
2Asisst. Lecturer Department of Community Health, Kufa, Technical Institute, Al-Furat Al-Awsat Technical University, Kufa, Al-Najaf, Iraq.
3Asisst. Lecturer Master of Bacteriology, Radiology Techniqes Department, College of Medical Technology. The Islamic University, Najaf, Iraq.
4Assist. Prof. Department of Medical Laboratory Techniques, Kufa Technical Institute, Al-Furat Al-Awsat Technical University, Kufa, Al-Najaf, Iraq.
5Department of medical Laboratory Techniques, Kufa Technical Institute, Al-Furat Al-Awsat Technical University, Kufa, Al-Najaf, Iraq.
*Corresponding Author
Published In:
Volume - 15,
Issue - 7,
Year - 2022
ABSTRACT:
Context: Repeated pregnancy loss is causing great distress to couples and undermining their confidence in achieving reproductive success in the future. A doctor can usually diagnose the cause and manage it directly, but in some cases, the cause is not known. Aim: This study aims to investigate whether there is a correlation between recurrent miscarriage and the level of protein S, C, age and blood groups in women who have experienced recurrent miscarriage without identifying a cause for this condition. Material and methods: one hundred twenty from infected women by recurrent abortion for unknown causes were classified according to age groups. Diagnosed blood group by using a specific kit for Biorex diagnostic Limited (the United Kingdom, 2016). The concentration of protein S and C were calculated by using the equipment produced by the AESKU.DIAGNOSTIC (Germany) Statistical analysis: the statistical analyses of the data were performed by using the (SPSS) 20.0 software package. We used the following analyses, frequencies, percentage, mean, stander diversion and Pearson correlation to identify the potential correlation between the miscarriage and the level of protein S, C, age and blood groups, the p-value of less than 0.05 was considered significant. Results: The study showed that out of a total of 120 women, who suffer from recurrent abortion, 82/120 have a decrease in the level of C protein, 96/120 have a decrease in the level of S protein and 74\120 have low level of both proteins C&S. The results were statistically significant (P=0.000, P=0.000 and p=0.000), There was an intermediate direct correlation between recurrent abortion and the level of proteins C and S (rp= 0.545, rp= 0.643), also there was correlation between the level of protein S and the level of protein C (rp=0.713). It was also found that there was no correlation between age and blood groups with cases of recurrent abortion in women the results was statistically non-significant (rp= - 0.084, p= 0.279; rp= 0.108, p=0.159). Conclusion: There are several reasons for the occurrence of recurrent abortion, including what is caused by microbial infections, or it may be caused by certain abnormalities in the reproductive system, etc., also appear to the results of this research, the low level of one of the proteins S, C or both may be a cause in the case of recurrent abortion.
Cite this article:
Maysoon Khudair. AL-Hadrawi, Ahmed Abdul Hasan Mohsin, Kais K.AL- Hadrawai, Noor Ismeal Nasser, Ali k. Metiab. Study the predictable correlation between recurrent abortion with the level of proteins S, C, age and blood groups in women in AL-Najaf governorate, Iraq. Research Journal of Pharmacy and Technology. 2022; 15(7):3200-4. doi: 10.52711/0974-360X.2022.00536
Cite(Electronic):
Maysoon Khudair. AL-Hadrawi, Ahmed Abdul Hasan Mohsin, Kais K.AL- Hadrawai, Noor Ismeal Nasser, Ali k. Metiab. Study the predictable correlation between recurrent abortion with the level of proteins S, C, age and blood groups in women in AL-Najaf governorate, Iraq. Research Journal of Pharmacy and Technology. 2022; 15(7):3200-4. doi: 10.52711/0974-360X.2022.00536 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-7-58
REFERENCES:
1. Macklon NS. Geraedts JPM. Fauser BCJM. Conception to ongoing pregnancy: the “black box” of early pregnancy loss. Hum Reprod Update. 2002;8:333–343.
2. Stephenson MD. Frequency of factors associated with habitual abortion in 197 couples. Fertil Steril. 1996;66:24–29.
3. Marlar RA. Neumann A. Neonatal purpura fulminans due to homozygous protein C or protein S deficiencies. Semin Thromb Hemost 1990;16: 299–309.
4. Lim W. Eikelboom JW. Ginsberg JS. Inherited thrombophilia and pregnancy associated venous thromboembolism. BMJ. 2007;334:1318–21
5. Brenner B. Thrombophilia and pregnancy loss in first intended pregnancy. J Thromb Haemost. 2005;3:2176–7.
6. Micco PD. Uva MD. Recurrent pregnancy loss and thrombophilia. Open Atheroscler Thromb J. 2009;2:33–5.
7. Kujovich JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol. 2004;191:412–24.
8. Preston FE. Rosendaal FR. Walker ID. Briët E. Berntorp E. Conard J. et al. Increased fetal loss in women with heritable thrombophilia. Lancet. 1996;348:913–6.
9. Carp H. Salomon O. Seidman D. Dardik R. Rosenberg N. Inbal A. Prevalence of genetic markers for thrombophilia in recurrent pregnancy loss. Hum Reprod. 2002;17:1633–7.
10. Bowles L. Cohen H. Inherited thrombophilias and anticoagulation in pregnancy. Best Pract Res Clin Obstet Gynaecol 2003;17: 471–89.
11. Coulam CB. Clark DA. Beer AE. et al. Current clinical options for diagnosis and treatment of recurrent spontaneous abortion. Am. J. Reprod. Immunol.1997;. 38:57–74
12. Preston FE. Rosendaal FR. Walker ID. et al. Increased fetal loss in women with heritable thrombophilia. Lancet.1996; 348: 913–916.
13. Marlar RA. Gausman JN. Protein S abnormalities: a diagnostic nightmare. Am J Hematol 2011; 86(5):418-21.
14. Lalan DM. Jassawalla MJ. Bhaleraonm SA. Successful Pregnancy Outcome in a Case of Protein S Deficiency. J Obstet Gynaecol India 2012; 62(1): 21–22.
15. Shinozaki N. Ebina Y. Deguchi M. Tanimura K. Morizane M. Yamada H. Protein S deficiency complicated pregnancy in women with recurrent pregnancy loss. Gynecological Endocrinology.2016; 32(8): 672-674.
16. Preston FE. Rosendaal FR. Walker I. Briët E. Berntorp E. et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348: 913-916.
17. Raziel AK. ornberg Y. Friedler S. Schachter M. Sela BA. et al. Hypercoagulable thrombophilic defects and hyperhomocysteinemia in patients with recurrent pregnancy loss. Am J ReprodImmunol 2001; 45: 65-71.
18. Rey E. Kahn SR. Davi M. Shrie, I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361 :901-908.
19. Vora S. Shetty S. Salvi V. Satoskar. Ghosh K. Thrombophilia and unexplained pregnancy loss in Indian patients. Natl Med J India 2008; 21:116-9.
20. Jyotsna. Sharma S. Trivedi SS. Coagulation inhibitors and activated protein C resistance in recurrent pregnancy losses in Indian women.2011; 54(4): 752-755.
21. Hansda J. Roychowdhury J. Study of Thrombophilia in Recurrent Pregnancy Loss. J Obstet Gynaecol India 2012; 62(5): 536–540.
22. Hussein N. Hadi M. Almosawi F. Deficiency of Protein C and Protein S in Recurrent Pregnancy Loss.2015.Babylon Journal, vol.12, No .2.page:348-356.
23. Magnu MC. Wilcox A J. Morken NH. Weinber CR. Håberg, SE. Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study. bmj,2019; 364.