Author(s): S Narendra Kumar, Chetan D M, Lingayya Hiremath, Ajeet Kumar Srivastava, Muralidhara P L, Jyothsana R, Rithika Pravin Iye, Ruchika Pravin Iyer

Email(s): narendraks@rvce.edu.in

DOI: 10.52711/0974-360X.2022.00535   

Address: S Narendra Kumar1, Chetan D M2, Lingayya Hiremath3, Ajeet Kumar Srivastava4, Muralidhara P L5, Jyothsana R6, Rithika Pravin Iye7, Ruchika Pravin Iyer8
1,3,4Assistant Professor, Department of Biotechnology, RV College of Engineering, Bangalore.
2Associate Professor, Department of Biotechnology, NMAMIT, NITTE, Karkala.
5Assistant Professor, Department of Chemical Engineering, RV College of Engineering, Bangalore.
6,7,8BE-Graduate Students, R V College of Engineeering, Bengaluru.
*Corresponding Author

Published In:   Volume - 15,      Issue - 7,     Year - 2022


ABSTRACT:
Cancer is a group of diseases which involves abnormal cell growth that can spread to other parts of the body. There are certain characteristics that are required to produce a malignant tumour. They include: Avoidance of programmed cell death and uncontrolled cell division to name a few. The progression from normal cells to cells that can form a detectable mass to outright cancer involves multiple steps known as malignant progression. Cannabinoids are among the treatment available. Recent research has shown that cannabinoid coupled with hydroxy citric acid can be used in the treatment of melanoma. Hydroxy citric acid is a derivative of citric acid well known for its anti-obesity and anti-inflammatory property. The current project involves the coupling of tetrahydrocannabinol with hydroxy citric acid to develop a novel drug molecule for potential cancer treatment. Simulation tool like Argus lab is used to construct the 3D structure of the novel drug. Autodock was used to bind the drug with the receptors like TRPV1, CB1, CB2, 4QO1 and 2YGB.


Cite this article:
S Narendra Kumar, Chetan D M, Lingayya Hiremath, Ajeet Kumar Srivastava, Muralidhara P L, Jyothsana R, Rithika Pravin Iye, Ruchika Pravin Iyer. Molecular Docking studies of THC-HCA on Cancer Receptors. Research Journal of Pharmacy and Technology. 2022; 15(7):3195-9. doi: 10.52711/0974-360X.2022.00535

Cite(Electronic):
S Narendra Kumar, Chetan D M, Lingayya Hiremath, Ajeet Kumar Srivastava, Muralidhara P L, Jyothsana R, Rithika Pravin Iye, Ruchika Pravin Iyer. Molecular Docking studies of THC-HCA on Cancer Receptors. Research Journal of Pharmacy and Technology. 2022; 15(7):3195-9. doi: 10.52711/0974-360X.2022.00535   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-7-57


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