Author(s): Goyal Rupendra, Jain Suman, Agarwal D D


DOI: 10.52711/0974-360X.2022.00517   

Address: Goyal Rupendra1*, Jain Suman2, Agarwal D D3
1Assistant Professor, SOS in Pharmaceutical Sciences, Jiwaji University, Gwalior (M.P.)
2Director, SOS in Pharmaceutical Sciences, Jiwaji University, Gwalior (M.P.)
3Professor, SOS in Chemistry, Jiwaji University, Gwalior (M.P.)
*Corresponding Author

Published In:   Volume - 15,      Issue - 7,     Year - 2022

Chemically, curcumin is a diaryl heptanoid, belonging to the group of curcuminoids, which are natural phenols responsible for turmeric's yellow color. It is a Keto–enol tautomer, existing in enolic form in organic solvents and in keto form in water. The one pot three component of hydrazide substituted benzaldehyde was used for the synthesis of curcumin derivatives. In this work the synthesis of curcumin derivatives was done using an environmental friendly procedure via Mg-Al-CO3 hydrotalcites which have been used as efficient catalysts. These catalysts are inexpensive and non-toxic powders. Data of Spectra and other analytical technique supported identification of compound curcumin derivatives. The present work offers many merits such as the reaction conditions were extremely simple, there was operational simplicity, reaction time was short, easy to work up and purification was also easy for the products via simple means of re-crystallization. The antibacterial activity of three compounds B2, B4 and D3 was found to be near to the significant with standard compounds amoxicillin.

Cite this article:
Goyal Rupendra, Jain Suman, Agarwal D D. Synthesis, characterization and antimicrobial study of novel substituted Curcumin Derivatives. Research Journal of Pharmacy and Technology. 2022; 15(7):3091-5. doi: 10.52711/0974-360X.2022.00517

Goyal Rupendra, Jain Suman, Agarwal D D. Synthesis, characterization and antimicrobial study of novel substituted Curcumin Derivatives. Research Journal of Pharmacy and Technology. 2022; 15(7):3091-5. doi: 10.52711/0974-360X.2022.00517   Available on:

1.    Hatamipour M, Johnston TP, Sahebkar A. One molecule, many targets and numerous effects: the pleiotropy of curcumin lies in its chemical structure. Current Pharmaceutical Design. 2018 May 1;24 (19):2129-36. DOI : 10.2174/1381612824666180522111036
2.    Slika L, Patra D. Traditional uses, therapeutic effects and recent advances of curcumin: a mini-review. Mini Reviews in Medicinal Chemistry. 2020 Jul 1;20 (12):1072-82.
3.    Vaishali. R. Undale, Sujata S. Kurkute, Srutuja S. Jadhav. Curcumin Potentiates Therapeutic Efficacy of Metformin: A Preclinical Study in STZ-NA Induced Hyperglycemia in Wistar Rats. Research J. Pharm. and Tech 2020; 13(6):2591-2596.
4.    Jithendra Chimakurthy, Talasila EGK Murthy, Lokesh Upadhyay. Effect of Curcumin on Sub-Therapeutic Doses of AED’S And Long Term Memory In MES Induced GTC Type of Seizures in Rats. Research J. Pharm. and Tech. Oct.-Dec. 2008; 1(4): 401-404.
5.    Aparna Satapathy, Mandava V. Rao. Protective effect of Curcumin on 2, 4- Dichlorophenoxy acetic acid exerted Hepatotoxicity in Mice. Research J. Pharm. and Tech 2018; 11(2):637-642.
6.    Jayandran. M, Muhamed Haneefa. M, Balasubramanian.V. Synthesis, Characterization and Antimicrobial Activities of Turmeric Curcumin and Curcumin Stabilized Zinc Nanoparticles - A Green Approach. Research J. Pharm. and Tech. April, 2015;8 (4): 445-451.
7.    Retno Murwanti, Eva Kholifah, B. S. Ari Sudarmanto, Adam Hermawan. Curcumin and its Analogue Targeting β-Catenin and GSK-3β in Wnt Signaling Pathways: In Vitro and In Silico Study. Research J. Pharm. and Tech. 2020; 13(4):1715-1719.
8.    Prashinta Nita Damayanti, Ritmaleni, Erna Prawita Setyowati. Synthesis and antibacterial activity of 4-Piperidone curcumin analogues against Gram-positive and Gram-negative bacteria. Research J. Pharm. and Tech. 2020; 13(10):4765-4769.
9.    Ritmaleni, Sardjiman, Indah Purwantini. Antimicrobial Activity of Curcumin Analog PGV-6, HGV-6 and GVT-6. Research J. Pharm. and Tech. 2021; 14(2):599-604.
10.    Krup V, Prakash LH, Harini A. Pharmacological activities of turmeric (Curcuma longa Linn): a review. J Homeop Ayurv Med. 2013;2 (133):2167-1206.
11.    Domling A, Wang W, Wang K. Chemistry and biology of multicomponent reactions. Chemical Reviews. 2012 Jun 13;112 (6):3083-135.
12.    Toure BB, Hall DG. Natural product synthesis using multicomponent reaction strategies. Chemical Reviews. 2009 Sep 9;109 (9):4439-86.
13.    Tejedor D, Garcia-Tellado F. Chemo-differentiating ABB′ multicomponent reactions. Privileged building blocks. Chemical Society Reviews. 2007;36 (3):484-91.
14.    Sahu PK, Sahu PK, Agarwal DD, Ahmad M, Messali M, Lahsasni S, Hadda TB. POM analyses of antimicrobial activity of 4 H-pyrimido [2, 1-b] benzothiazole, pyrazole, and benzylidene derivatives of curcumin. Medicinal Chemistry Research. 2015 Jun;24 (6):2381-92.
15.    Tanabe K. Catalytic application of niobium compounds. Catalysis Today. 2003 Feb 28;78 (1-4):65-77.
16.    Robu M, Tanase C, Boscornea C, Tomas S, Albulescu R. Curcumin derivatives with potential biological activity. Circulation. 2009 Jan 1;4:5.
17.    Alshehri SM, Naushad M, Ahamad T, Alothman ZA, Aldalbahi A. Synthesis, characterization of curcumin based ecofriendly antimicrobial bio-adsorbent for the removal of phenol from aqueous medium. Chemical Engineering Journal. 2014 Oct 15; 254:181-9.
18.    Khan AT, Lal M, Ali S, Khan MM. One-pot three-component reaction for the synthesis of pyran annulated heterocyclic compounds using DMAP as a catalyst. Tetrahedron Letters. 2011 Oct 12;52 (41):5327-32.
19.    Bratu MG. Synthesis of curcumin derivatives. Acta Universitatis Cibiniensis Series E: Food Technology. 2005;9 (1):11.
20.    Balouiri M, Sadiki M, Ibnsouda SK. Methods for in vitro evaluating antimicrobial activity: A review. Journal of Pharmaceutical Analysis. 2016 Apr 1;6 (2):71-9.
21.    D.L. Mayers, S.A. Lerner, M. Ouelette, et al. Antimicrobial Drug Resistance C: Clinical and Epidemiological Aspects, vol. 2, Springer Dordrecht Heidelberg, London (2009) pp. 681–1347.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available