Nisha kumari, Amit Chaudhary, Kapil Kumar Verma, Kritika Verma, Geetanjali Saini, Manish Vyas, Bhupendra Singh
Nisha kumari1, Amit Chaudhary2, Kapil Kumar Verma2, Kritika Verma2, Geetanjali Saini4, Manish Vyas3, Bhupendra Singh4*
1Abhilashi College of Pharmacy, Mandi, HP.
4College of Pharmacy, Teerthankar Mahaveer University, Moradabad, UP.
2School of Pharmacy, Abhilashi University, Mandi H.P, India.
3School of Pharmaceutical Sciences, Lovely Professional University Phagwara.
Volume - 15,
Issue - 7,
Year - 2022
A simple, accurate, precise, and rapid UV spectrophotometric method was developed for simultaneous estimation of Etoricoxib and Thiocolchicoside in the tablet dosage form. Etoricoxib showed maximum absorbance at 270 nm, while Thiocolchicoside showed maximum absorbance at 260 nm. These two wavelengths were selected for further analysis. The developed method was validated as ICH guidelines including parameters as linearity, range, precision, LOD, LOQ, and accuracy. The absorbance range for Etoricoxib (5-30 µg/ml) was found to be 0.210-0.799. These aliquots obeyed Beer-Lambert’s law with regression of 0.995. The absorbance range of Thiocolchicoside (5-30 µg/ml) was found to be 0.147-0.468 with a regression of 0.998. The method of precision (interday, intraday) was found within limits (RSD>2). The % recovery was found to be within the range. As per the ICH Q2 R1 guideline, the result was validated statistically and was found to be satisfactory.
Cite this article:
Nisha kumari, Amit Chaudhary, Kapil Kumar Verma, Kritika Verma, Geetanjali Saini, Manish Vyas, Bhupendra Singh. Development and validation of an analytical method for the simultaneous estimation of Etoricoxib and Thiocolchicoside in tablet dosage form by UV Spectrophotometric method. Research Journal of Pharmacy and Technology. 2022; 15(7):3051-6. doi: 10.52711/0974-360X.2022.00510
Nisha kumari, Amit Chaudhary, Kapil Kumar Verma, Kritika Verma, Geetanjali Saini, Manish Vyas, Bhupendra Singh. Development and validation of an analytical method for the simultaneous estimation of Etoricoxib and Thiocolchicoside in tablet dosage form by UV Spectrophotometric method. Research Journal of Pharmacy and Technology. 2022; 15(7):3051-6. doi: 10.52711/0974-360X.2022.00510 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-7-32
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