Author(s): Dwi Yani Sastika, Trimurni Abidin, Harry Agusnar, Basri A. Gani

Email(s): tri.murni@usu.ac.id and , basriunoe@unsyiah.ac.id

DOI: 10.52711/0974-360X.2022.00496   

Address: Dwi Yani Sastika1, Trimurni Abidin1*, Harry Agusnar2, Basri A. Gani3*
1Department of Conservative Dentistry, Faculty of Dentistry, Universitas Sumatera Utara Medan-Indonesia.
2Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Sumatera Utara, Medan Indonesia.
3Department of Oral Biology, Dentistry Faculty, Universitas Syiah Kuala, Darussalam, Banda Aceh, Aceh, Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 7,     Year - 2022


ABSTRACT:
Calcium hydroxide is often used as a root canal medicament. Together with vehicle aqueous, glycerine, polyethylene glycol, and chitosan can increase calcium ion diffusion, pH balance, and anti-bacterial power. To analyze the effect of different vehicles on alkaline pH changes, diffusion of calcium ions, roughness, and frequency of chemical elements in the root canal after applying calcium hydroxide. A total of 100 dental samples in 5 groups of vehicles were examined for pH using a pH meter, calcium ion diffusion using Atomic Absorption Spectrophotometric, and surface roughness of the root canals chemical compounds were analyzed by SEM-EDX. All the vehicles can maintain the balance of pH changes to alkaline in the root canal wall (p<0.05: 0.00). Maximum calcium ion diffusion occurs on day 30, especially in the vehicle Chitosan and Polyethylene glycol (p <0.05: 0.00). Vehicle chitosan and glycerine more strongly reduce root surface wall roughness after calcium hydroxide medicament (20% roughness score). Specifically, vehicle chitosan can increase calcium (21.71%) compared to control and other vehicles in the root canal wall (p<0.05: 0.02). The chitosan vehicles and other vehicles can maintain an alkaline pH balance, diffusion of calcium ions, and decrease in roughness and increase in the quantity of calcium in the root canal wall.


Cite this article:
Dwi Yani Sastika, Trimurni Abidin, Harry Agusnar, Basri A. Gani. Application of Calcium Hydroxide with Vehicles Relate to the pH Change, Calcium Ion Diffusion, Roughness, and Frequency of Chemical Compound in Root Canal. Research Journal of Pharmacy and Technology. 2022; 15(7):2976-2. doi: 10.52711/0974-360X.2022.00496

Cite(Electronic):
Dwi Yani Sastika, Trimurni Abidin, Harry Agusnar, Basri A. Gani. Application of Calcium Hydroxide with Vehicles Relate to the pH Change, Calcium Ion Diffusion, Roughness, and Frequency of Chemical Compound in Root Canal. Research Journal of Pharmacy and Technology. 2022; 15(7):2976-2. doi: 10.52711/0974-360X.2022.00496   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-7-18


REFERENCES:
1.    Insira JS, James DR. Survey based research on Patients Knowledge about Endodontic Treatment. Research Journal of Pharmacy and Technology. 2016; 9(10):1565-1567.
2.    Lavanya E, Jayalakshmi S, Antony DP. Intracanal Medicaments in Revascularization-A Review. Research Journal of Pharmacy and Technology. 2018;11(6): 2672-2676. doi.org/10.5958/0974-360X.2018.00495.X
3.    Abiraamasri BL, Gurunathan D. Comparison of Ferric Sulphate and Calcium Hydroxide as A Pulpotomy Agent. Research Journal of Pharmacy and Technology. 2018; 11(5):1881-1883. doi.org/10.5958/0974-360X.2018.00349.9
4.    Ma J, Shen Y, Yang Y, et al. In vitro study of calcium hydroxide removal from mandibular molar root canals. Journal of Endodontics. 2015;41(4):553-58. doi.org/10.1016/j.joen.2014.11.023
5.    Mohammadi Z, Shalavi S, Yazdizadeh M. Antimicrobial activity of calcium hydroxide in endodontics: a review. Chonnam Medical Journal. 2012;48(3):133-40. doi.org/10.4068%2Fcmj.2012.48.3.133
6.    Millán JL, Whyte MP. Alkaline phosphatase and hypophosphatasia. Calcified Tissue International 2016;98(4):398-416. doi.org/10.1007/s00223-015-0079-1
7.    Athanassiadis B, Walsh LJ. Aspects of Solvent Chemistry for Calcium Hydroxide Medicaments. Materials. 2017;10(10):1219. doi.org/10.3390/ma10101219
8.    Mohammadi Z, Shalavi S. Calcium hydroxide in traumatic dental injuries: an update review. International Journal of Clinical Dentistry. 2015;8(2).
9.    Phukan AH, Mathur S, Sandhu M, Sachdev V. The effect of different root canal sealers on the fracture resistance of endodontically treated teeth-in vitro study. Dental Research Journal. 2017;14(6):382. https://doi.org/10.4103/1735-3327.218558
10.    Kmiec M, Pighinelli L, Tedesco M, Silva M, Reis V. Chitosan-properties and applications in dentistry. Adv Tissue Eng Regen Med Open Access. 2017;2(4):00035. doi.org/10.15406/atroa.2017.02.00035
11.    Anitha T, Sathishkumar K. Comparative Study of Adsorption for Chitosan, Sand and Chitosan Coated Sand. Asian Journal Pharmaceutical and Technology. 2013; 3 (4): 185-188.
12.    Kim D, Kim E. Antimicrobial effect of calcium hydroxide as an intracanal medicament in root canal treatment: a literature review-Part I. In vitro studies. Restorative Dentistry and  Endodontics. 2014;39(4):241-52. doi.org/10.5395%2Frde.2014.39.4.241
13.    Johnson WT, Noblett WC. Cleaning and shaping. Endodontics: Principles and Practice 2009;4-9.
14.    G. Lokhasudhan, Ajitha. P. Role of Antibiotics as Intracanal Medicament – A Literature Review. Research Journal of Pharmacy and Technology. 2018; 11(4): 1691-1696. doi.org/10.5958/0974-360X.2018.00315.3
15.    Virdee S, Seymour D, Farnell D, Bhamra G, Bhakta S. Efficacy of irrigant activation techniques in removing intracanal smear layer and debris from mature permanent teeth: a systematic review and meta‐analysis. International Endodontic Journal. 2018;51(6):605-21. doi.org/10.1111/iej.12877
16.    Carlotto IB, Luisi SB, Kopper PMP, Grecca FS, Montagner F. Calcium hypochlorite solutions: evaluation of surface tension and effect of different storage conditions and time periods over pH and available chlorine content. Journal of Endodontics. 2016;42(4):641-45. doi.org/10.1016/j.joen.2016.01.006
17.    Saveetha University, Chennai. Use of Antibiotics in Endodontics – Clinical Practice Guidelines. Research Journal of Pharmacy and Technology. 2019; 12(1): 419-424. doi.org/10.5958/0974-360X.2019.00076.3
18.    Athanassiadis B, Abbott P, Walsh LJ. The use of calcium hydroxide, antibiotics and biocides as antimicrobial medicaments in endodontics. Australian Dental Journal. 2007;52:S64-S82. doi.org/10.1111/j.1834-7819.2007.tb00527.x
19.    Kumari DG, Raksha G, Deepak K, Anjana G, Mary CS. A Review on Chitosan Nanoparticle as a Drug delivery system. Asian J. Pharm. Res. 2020; 10(4):299-306. doi.org/10.5958/2231-5691.2020.00051.9
20.    Jhajharia K, Parolia A, Shetty KV, Mehta LK. Biofilm in endodontics: a review. Journal of International Society of Preventive & Community Dentistry. 2015;5(1):1-4. doi.org/10.4103/2231-0762.151956
21.    Wang N, Ji Y, Zhu Y, et al. Anti-bacterial effect of chitosan and its derivative on Enterococcus faecalis associated with endodontic infection. Experimental and Therapeutic Medicine. 2020;19(6):3805-13. doi.org/10.3892%2Fetm.2020.8656
22.    Eliaz N, Metoki N. Calcium phosphate bioceramics: a review of their history, structure, properties, coating technologies and biomedical applications. Materials. 2017;10(4):334. doi.org/10.3390%2Fma10040334
23.    Grover C, Shetty N. Evaluation of calcium ion release and change in pH on combining calcium hydroxide with different vehicles. Contemporary Clinical Dentistry. 2014;5(4):434. doi.org/10.4103/0976-237x.142803
24.    Estrela C, Sydney GB, Pesce HF. Dentinal diffusion of hydroxyl ions of various calcium hydroxide pastes. Brazilian Dental Journal. 1995;6(1):5-9.
25.    Jain V, Garg G, Patil UK, Jain S. Recent Perspectives of Chitosan: A Review. Research Journal of Pharmaceutical Dosage Forms and Technology. 2010; 2(3): 220-224 .
26.    Mohammadi Z, Dummer PMH. Properties and applications of calcium hydroxide in endodontics and dental traumatology. International Endodontic Journal 2011;44(8):697-730. doi.org/10.1111/j.1365-2591.2011.01886.x
27.    Carvalho CN, Freire LG, Carvalho APLd, et al. Ions release and pH of calcium hydroxide-, chlorhexidine-and bioactive glass-based endodontic medicaments. Brazilian Dental Journal. 2016;27(3):325-31. doi.org/10.1590/0103-6440201600602
28.    Carvalho CN, Freire LG, de Carvalho APL, et al. The influence of dentine on the pH of calcium hydroxide, chlorhexidine gel, and experimental bioactive glass-based root canal medicament. The Scientific World Journal. 2015;2015. doi.org/10.1155/2015/686259
29.    Jamil T, Javadi A, Heinz H. Mechanism of molecular interaction of acrylate-polyethylene glycol acrylate copolymers with calcium silicate hydrate surfaces. Green Chemistry. 2020;22(5):1577-93.
30.    Teoh Y-Y, Athanassiadis B, Walsh LJ. Comparison of commercial calcium hydroxide pastes for prolonged anti-bacterial effect using a colourimetric assessment. Materials 2018;11(3):348. doi.org/10.3390%2Fma11030348
31.    Akshay R. Yadav, Shrinivas KM. Aquasomes as a Self Assembling Nanobiopharmaceutical Carrier System for Bio-Active Molecules. Research Journal Topical and Cosmetic Sciences. 2020; 11(2):89-94. doi.org/10.5958/2321-5844.2020.00016.3
32.    Sachin R. Kumbhoje, Zaki Husain JT, D'Souza JI. Synthesis and Characterization of Schiff bases of Chitosan for their Improved Mucoadhesion. Asian Journal Research in Chemistry. 2012;5(9): 1099-1103.
33.    Arslan H, Topcuoglu HS, Karatas E, et al. Effect of the smear layer in the removal of calcium hydroxide from root canal walls. Journal of Conservative Dentistry: JCD. 2012;15(2):113. doi.org/10.4103%2F0972-0707.94574
34.    da Silva JM, Silveira A, Santos E, Prado L, Pessoa OF. Efficacy of sodium hypochlorite, ethylenediaminetetraacetic acid, citric acid and phosphoric acid in calcium hydroxide removal from the root canal: a microscopic cleanliness evaluation. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontology. 2011;112(6):820-24. doi.org/10.1016/j.tripleo.2011.08.001
35.    Misra P, Bains R, Loomba K, et al. measurement of pH and calcium ions release from different calcium hydroxide pastes at different intervals of time: atomic spectrophotometric analysis. Journal of Oral Biology and Craniofacial Research. 2017;7(1):36-41. doi.org/10.1016/j.jobcr.2016.04.001
36.    Pimenta JA, Zaparolli D, Pécora JD, Cruz-Filho AM. Chitosan: effect of a new chelating agent on the microhardness of root dentin. Brazilian Dental Journal 2012;23(3):212-17. doi.org/10.1590/S0103-64402012000300005

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

1.3
2021CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank

Journal Policies & Information


Recent Articles




Tags


Not Available