Rishu Yadav, Narendra Kumar Pandey, Rajiv Kukkar, Deepika Dutta, Preeti Avasthi, Monika Rana, Swati Modgil
Rishu Yadav1,3, Narendra Kumar Pandey1, Rajiv Kukkar2, Deepika Dutta3, Preeti Avasthi3, Monika Rana3, Swati Modgil3
1School of Pharmaceutical Sciences, Lovely Professional University, Phagwara, Punjab, India.
2Raffles University, Neemrana, Rajasthan, India.
3Maharaja Agrasen University, Baddi, H.P. India.
Volume - 15,
Issue - 6,
Year - 2022
Topical drug delivery can be defining as good delivery system for drugs, in which drug directly get interact with skin and give its pharmacological effect to desired site to cure and treat variety of disorder. Gel has major disadvantage because it cannot prepare for hydrophobic drugs this type of limitation can be defeated by emulgel. Emulgel have dual property like emulsion and gel and gives dual release system. Primary disadvantage of lipophilic drug that it does not dissolves in aqueous solvent and cause problem in drug delivery. Emulgels gives a good advantage over gel that hydrophobic drugs are easily dissolve in oil phase and then added in aqueous phase to form w/o type emulsion. These emulgel then incorporate into gel to form emulgel. Emulgel are good carrier for topical delivery of lipophilic drugs and have several advantages over different drug delivery system. Emulgel give better patient compliance and promote controlled pattern of drug delivery due to presence of cross linked structure of gelling agent. Emulgels formulations can be used for anti-inflammatory, analgesic, antifungal, acne, skin disorder and also in form of cosmetic products.
Cite this article:
Rishu Yadav, Narendra Kumar Pandey, Rajiv Kukkar, Deepika Dutta, Preeti Avasthi, Monika Rana, Swati Modgil. Emulgel A Reliable System for Topical Delivery of Lipophilic Drugs in Present Scenario: Review. Research Journal of Pharmacy and Technology. 2022; 15(6):2845-8. doi: 10.52711/0974-360X.2022.00475
Rishu Yadav, Narendra Kumar Pandey, Rajiv Kukkar, Deepika Dutta, Preeti Avasthi, Monika Rana, Swati Modgil. Emulgel A Reliable System for Topical Delivery of Lipophilic Drugs in Present Scenario: Review. Research Journal of Pharmacy and Technology. 2022; 15(6):2845-8. doi: 10.52711/0974-360X.2022.00475 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-79
1. Soosai Raj. Balakrishnan S. Short Review - Emulgel. J Compr Pharm. 2016;03(01):34–7. doi.org/10.37483/jcp.2016.3105
2. Dange V. Shid S. Mohite C. et al. A Review : Dry Emulsion. 2015;5(4):208–10. doi.org10.5958/2231-5691.2015.00032.5
3. Rao M. Aghav S. Kumar M. Optimization of Metronidazole Emulgel. 2013;2013. .doi.org/10.1155/2013/501082
4. Weremfo A. Pappoe ANM. Adinortey MB. Wound Healing Potential of Musa paradisiaca L . ( Musaceae ) Stem Juice Extract Formulated into an Ointment. 2011;3(6):294–6. (DOI NOT AVAILABLE)
5. Derle D V. Bsh S. Yeole DR. Development and Evaluation of Topical Microemulsion Gels for Protein and Peptide Drug Bacitracin Zinc. 2009;1(3):217–21.
6. Tiwari S. Singh S. Tripathi PK. et al. A Review- Nanogel Drug Delivery System. 2015;5(4):253–5.
7. Sawant AA. Mohite SK. Formulation and Evaluation of Itraconazole Emulgel for Topical Drug Delivery. 2015;5(2):91–6. doi.org/10.5958/2231-5713.2015.00014.8
8. Mehta DP. Rathod H J. Shah DP. et al. A Review on Microemulsion Based Gel : A Recent Approach for Topical Drug Delivery System. 2015;8(February):118–26. doi.org/ 10.5958/0974-360X.2015.00021.
9. Karudumpala S. Sangeeetha G. Praksh KG. et al. Formulation and Evaluation of Carisoprodol Topical Gel. 2014;7(January):34–8.
10. Banerjee A. Thiangarjan N. Thiangarajan P. Research article A Flaxseed Oil emulgel formulation for Prospective Food Applications Synthesis and Characterization. 2017;10(June):1802–8.doi.org/10.5958/0974-360X.2017.00318.3
11. Khullar R. Kumar D. Seth N. et al. Formulation and evaluation of mefenamic acid emulgel for topical delivery. Saudi Pharm J [Internet]. 2012;20(1):63–7. Available from: http://dx.doi.org/10.1016/j.jsps.2011.08.001
12. Eswaraiah S. Swetha K. Lohita M.et al. Emulgel : Review on Novel Approach to Topical Drug Delivery. 2014;4(1):4–11.doi.org/ 040/IJPSR.0975-8232.5(5).1653-60
13. Sravan VN. Varma K. Maheshwari P V, et al. Calcipotriol delivery into the skin as emulgel for effective permeation.2014;22(6):591–9.doi.org/10.1016/j.jsps.2014.02.007
14. Sapkal K. Nashik- D. A Review on Self- Micro Emulsifying Drug Delivery System : Evident to improve the oral bioavailability of hydrophobic drugs. 2016;6(2):131–4.doi.org/ 10.5958/2231-5713.2016.00018.0
15. Hardenia A, Road K. Emulgel: An emergent toool in Topical Drug Delivery. 2014;5(5):1653–60. doi.org/10.13040/IJPSR.0975-8232.5(5).1653-60
16. Mohamed MI. Optimization of chlorphenesin emulgel formulation. AAPS J. 2004;6(3):1–7. doi.org/ 10.3390/pharmaceutics11110609
17. Reins RY. Hanlon SD. Magadi S. et al. Effects of topically applied Vitamin D during corneal wound healing. PLoS One. 2016;11(4):1–19.doi.org/ 10.1371/journal.pone.0152889
18. Barrea L. Savanelli MC. Di Somma C, et al. Vitamin D and its role in psoriasis: An overview of the dermatologist and nutritionist. Rev Endocr Metab Disord. 2017;18(2):195–205. doi.org/ 10.1007/s11154-017-9411-6
19. Coussens AK. Martineau AR. Wilkinson RJ. Anti-Inflammatory and Antimicrobial Actions of Vitamin D in Combating TB/HIV. Scientifica (Cairo). 2014;2014:1–13.doi.org/ 10.1371/journal.pone.0152889