Author(s):
Deni Firmansyah, Sulistiorini Indriaty, Sri Adi Sumiwi, Nyi Mekar Saptarini, Jutti Levita
Email(s):
denif6982@gmail.com
DOI:
10.52711/0974-360X.2022.00472 
Address:
Deni Firmansyah1,2*, Sulistiorini Indriaty3, Sri Adi Sumiwi1, Nyi Mekar Saptarini4, Jutti Levita1
1Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, West Java, Indonesia 45363.
2Department of Pharmacology, School of Pharmacy Muhammadiyah Cirebon, West Java, Indonesia 45153.
3Department of Technology of Pharmacy and Cosmetics, School of Pharmacy Muhammadiyah Cirebon, West Java, Indonesia 45153.
4Department of Pharmaceutical Analysis and Medicinal Chemistry, Faculty of Pharmacy, Universitas Padjadjaran, West Java, Indonesia 45363.
*Corresponding Author
Published In:
Volume - 15,
Issue - 6,
Year - 2022
ABSTRACT:
It has been almost thirty years since the first publication on microphthalmia-associated transcription factor (MITF) in 1993. MITF, which plays an important role in the melanogenesis process, is an interesting target for melanoma therapy, due to its associates with melanoma survival. MITF promotes melanoma cell proliferation, whereas the sustained suppression of MITF expression causes aging. MITF contributes to differentiation, which involves breaking out of the cell cycle and triggering a melanogenesis, and this function appears to often persist during melanoma development given the frequently observed high pigmented lesions, even in the late stages of melanoma. Several drugs that could inhibit MITF e.g. histone deacetylase inhibitors, such as sodium butyrate and trichostatin A, have been proven could suppress M-MITF expression in melanoma cells. H1-receptor antagonists, particularly loratadine, could downregulate MITF and tyrosinase in melanocytes. Some plants can inhibit MITF e.g Gentiana veitchiorum Hemsl., Thymelaea hirsuta, Argania spinosa L. In this review, we update the information about MITF and describe the mechanism of its inhibitors in preventing melanogenesis.
Cite this article:
Deni Firmansyah, Sulistiorini Indriaty, Sri Adi Sumiwi, Nyi Mekar Saptarini, Jutti Levita. Microphthalmia Transcription Factor almost Thirty Years after: Its Role in Melanogenesis and its Plant-Derived Inhibitors. Research Journal of Pharmacy and Technology. 2022; 15(6):2825-0. doi: 10.52711/0974-360X.2022.00472
Cite(Electronic):
Deni Firmansyah, Sulistiorini Indriaty, Sri Adi Sumiwi, Nyi Mekar Saptarini, Jutti Levita. Microphthalmia Transcription Factor almost Thirty Years after: Its Role in Melanogenesis and its Plant-Derived Inhibitors. Research Journal of Pharmacy and Technology. 2022; 15(6):2825-0. doi: 10.52711/0974-360X.2022.00472 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-76
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