Author(s): S. A. Khedkar, J. S. Patil, P. M. Sabale


DOI: 10.52711/0974-360X.2022.00403   

Address: S. A. Khedkar1, J. S. Patil2, P. M. Sabale3
1Department of Pharmaceutical Chemistry, JNT University, Kakinada, Andhra Pradesh, India.
2Shivajirao Jondhale College of Pharmacy, Asangaon, Maharashtra, India.
3Rashtrasant Tukadoji Maharaj University, Nagpur, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022

A series of 24 condensed pyrimidine derivatives was synthesized via multistep reactions using microwave radiation and have opted to explore the possible inhibition mechanism via virtual analysis by using V life MDS. The synthesized compounds were characterized by spectroscopic analysis. All the synthesized compounds were found to show good in-silico binding analysis which indicated their potential to explore as good antimicrobial agents. All the synthesized derivatives were screened in-vitro for their antibacterial activity against two gram positive and gram negative bacteria. Among the compounds tested, SAKB2, SAKB7, SAKB8, SAKB9 SAKB10, SAKB11, SAKB12 and SAKB13derivatives exhibited potent antimicrobial activity.

Cite this article:
S. A. Khedkar, J. S. Patil, P. M. Sabale. Design and Synthesis, In Silico Analysis of Condensed Pyrimidine derivatives as Potent Antimicrobial Agents. Research Journal of Pharmacy and Technology. 2022; 15(6):2422-6. doi: 10.52711/0974-360X.2022.00403

S. A. Khedkar, J. S. Patil, P. M. Sabale. Design and Synthesis, In Silico Analysis of Condensed Pyrimidine derivatives as Potent Antimicrobial Agents. Research Journal of Pharmacy and Technology. 2022; 15(6):2422-6. doi: 10.52711/0974-360X.2022.00403   Available on:

1.    Mohamed M., Awad S., Sayed IA. Synthesis of Certain Pyrimidine Derivatives as Antimicrobial Agents and Anti-Inflammatory Agents. Molecules. 2010; 15(3): 1882-1890.
2.    Mallikarjunaswamy C., Mallesha L., Bhadregowda D., Pinto O. Studies on synthesis of pyrimidine derivatives and their antimicrobial activity. Ara J of Chem. 2017; 10: S484-S490.
3.    Bhatt HS. S; 2-(5-Chlorobenzo[d]thiazol-2-ylimino) thiazolidin-4- one derivatives as an antimicrobial agent. Ara J. of Chem. 2017; 10: S531–S538.
4.    Dişli A., Mercan, S., Yavuz, S. Synthesis and Antimicrobial Activity of New Pyrimidine Derivatives Incorporating 1H-Tetrazol-5-ylthio Moiety. J of Het. Chem. 2013; 50: 1446-1450.
5.    Cieplik J., Stolarczyk M., Pluta J., Gubrynowicz O., Bryndal I., Lis T. Synthesis and Antibacterial Properties of Pyrimidine Derivatives. Acta Pol. Pharma. 2011; 68(1): 57- 65. PMID: 21485702
6.    Andrews B., Komathi K., Mohan S. Synthesis and comparing the antibacterial activities of pyrimidine derivatives. J. Chem. Sci. 2017; 129: 335–341.
7.    Vaghasia SJ., Shah VH. Microwave assisted synthesis and antimicrobial activity of some novel pyrimidine derivatives. J. Serb. Chem. Soc. 2007; 72 (2): 109–117. doi: 10.2298/JSC0702109V
8.    Ashour HM., Shaaban OG., Rizk OH., El-Ashmawy IM. Synthesis and biological evaluation of thieno[20,30:4,5]pyrimido[1,2-b][1,2,4]triazines and thieno[2,3-d][1,2,4]triazolo[1,5-a] pyrimidines as anti-inflammatory and analgesic agents. Eur. J. Med. Chem. 2013; 62: 341-351. doi: 10.1016/j.ejmech.2012.12.003
9.    Laddha SS., Bhatnagar SP. Efficient Niementowski synthesis of novel derivatives of 1,2,9,11-tetrasubstituted-7H-thieno[2',3':4,5]pyrimido[6,1-b]-quinazolin-7-one. ARKIVOC. 2008; 17: 212-220.
10.    Jang M., De Jonghe S., Van Belle K., Louat T., Waer M, Herdewijn P. Synthesis, immunosuppressive activity and structure–activity relationship study of a new series of 4-N-piperazinyl-thieno[2,3-d]pyrimidine analogues. Bioorg. Med. Chem. Lett. 2010; 20: 844-847. doi: 10.1016/j.bmcl.2009.12.098
11.    Shaaban OG., Rizk OH., El-Ashmawy IM. Design, synthesis and biological evaluation of some novel thienopyrimidines and fused thienopyrimidines as anti-inflammatory agents. Eur. J. Med. Che. 2012; 55: 85-93. doi: 10.1016/j.ejmech.2012.07.007
12.    Leung C., Langille AM., Mancuso J., Tsantrizos YS. Discovery of thienopyrimidine-based inhibitors of the human farnesyl pyrophosphate synthase-Parallel synthesis of analogs via a trimethylsilyl ylidene intermediate. Bioorg. Med. Chem. 2013; 21(8): 2229-2240. doi: 10.1016/j.bmc.2013.02.006.
13.    Firestine SM., Mahender BD., Wani AS., Vidaillac C., Oupicky D., Rybak MJ. Thieno [2,3-d]pyrimidinedione derivatives as antibacterial agents. Eur. J. Med. Chem. 2012; 51: 45-153. doi: 10.1016/j.ejmech.2012.02.035
14.    Khazi AM.., Mulla JAS, Khazi MIA, Panchamukhi SI., Gong Y. Synthesis and pharmacological evaluation of novel thienopyrimidine and triazolothienopyrimidine derivatives. Med. Che. Res. 2014; 23: 3235-3243.
15.    Adepu R., Kumar KS., Sandra S., Rambabu D., Rama Krishna G., Malla Reddy C., Kandale A., Misra P., Pal M. C–N bond formation under Cu-catalysis: Synthesis and in vitro evaluation of N-aryl substituted thieno[2,3-d]pyrimidin-4(3H)-ones against chorismate mutase. Bioorg. Med. Chem. 2012; 20: 5127–5138. doi: 10.1016/j.bmc.2012.07.011
16.    Deng J., Peng L., Zhang G., Lan X., Li C., Chen F., Zhou Y., Lin Z., Chen L., Dai R., Xu H., Yang L., Zhang X., Hua W. The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes. Eur. J. Med. Chem. 2011; 46: 71-76. Doi: 10.1126/science.abb4489
17.    Abbas SE., Abdel Gawad NM., George RF., Akar YA. Synthesis, antitumor and antibacterial activities of some novel tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidine derivatives. Eur. J. Med. Chem. 2013; 65: 195-204. doi: 10.1016/j.ejmech.2013.04.055
18.    Singh S., Sharma PK., Dudhe R., Kumar N. Synthesis of Pyrazolopyrimidine Derivatives and Their Antibacterial Activity. Asian J. Research Chem. 2011; 4(10): 1594-1599.
19.    Pavlo V. Zadorozhnii, Vadym V. Kiselev, Nataliia O. Teslenko, Aleksandr V. Kharchenko, Ihor O. Pokotylo, Oxana V. Okhtina, Oxana V. Kryshchyk. In Silico Prediction and Molecular Docking Studies of N-Amidoalkylated Derivatives of 1,3,4-Oxadiazole as COX-1 and COX-2 Potential Inhibitors. Research J. Pharm. and Tech. 2017; 10(11): 3957-3963. doi: 10.5958/0974-360X.2017.00718.1
20.    Hemalatha K., Joseph Selvin, Girija K. Synthesis, In silico Molecular Docking Study and Anti-bacterial Evaluation of some Novel 4-Anilino Quinazolines. Asian J. Pharm. Res. 2018; 8(3): 125-132. doi: 10.5958/2231-5691.2018.00022.9
21.    Kawade VS., Kumbhar SS., Choudhari PB., Bhatia MS. 3D QSAR and Pharmacophore Modeling of some Pyrimidine Analogs as CDK4 Inhibitors. Asian J. Research Chem. 2015; 8(4): 231-235. doi: 10.4172/pharmaceutical-sciences.1000295
22.    Divekar K., Rekha S., Vedigounder M., Shivaprakash H. Synthesis, Characterization and Evaluation of some newer Pyrimidine derivatives as Anti-inflammatory Agents. Research Journal of Pharmacy and Technology. 2021; 14(5): 2529. doi: 10.52711/0974-360X.2021.00445
23.    Sharma B., Jain A., Sharma D., Dubey A. Microwave Assisted Improved Synthesis of Some Novel Heterofused Pyrazolopyrimidines Derivatives and Their Antimicrobial Activity. Asian J. Research Chem. 2011; 4(10): 1616-1620.
24.    Kumari S., Gupta V., Singh S., Gupta YK. Synthesis, Characterization and Amtimicrobial Activities of Some New Amino Pyrimidine Derivatives. Research J. Pharm. And Tech. 2019; 12(1): 167-171. doi: 10.5958/0974-360X.2019.00031.3
25.    Kodical DD., Jainey PJ., Deepthi K., Pankaj K. Chinchumol Cyriac, Gopika KV. ADMET, Molecular docking studies and binding energy calculations of Pyrimidine-2-Thiol Derivatives as Cox Inhibitors. Research J. Pharm. and Tech. 2020; 13(9): 4200-4206. doi: 10.5958/0974-360X.2020.00742.8
26.    Chauhan S., Gyananchandran AK., Tiwari P., Sharma S., Shukla SS. Synthesis and Antimicrobial activity of Pyrimidine Derivatives from Amine. Research J. Pharm. and Tech. April 2011;4(4):624-628.
27.    Ramachandran S., Vimeshya N., Yogeshwaran K., Cheriyan BV., Aanandhi MV. Molecular Docking Studies, Synthesis, Characterisation, and Evaluation of Azetidine-2-One Derivative. Research J. Pharm. and Tech. 2021; 14(3): 1571-1575. doi : 10.5958/0974-360X.2021.00277.8
28.    Lafitte D., Lamour V., Tsvetkov, PO., Makarov, AA., Klich, M., Deprez, P., Moras, D., Briand, C., Gilli, R. DNA gyrase interaction with coumarin-based inhibitors: the role of the hydroxybenzoate isopentenyl moiety and the 5'-methyl group of the noviose. Biochemistry. 2002; 41: 7217-7223.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available