Author(s): S. A. Khedkar, J. S. Patil, P. M. Sabale

Email(s): samratkhedkar@yahoo.in

DOI: 10.52711/0974-360X.2022.00403   

Address: S. A. Khedkar1, J. S. Patil2, P. M. Sabale3
1Department of Pharmaceutical Chemistry, JNT University, Kakinada, Andhra Pradesh, India.
2Shivajirao Jondhale College of Pharmacy, Asangaon, Maharashtra, India.
3Rashtrasant Tukadoji Maharaj University, Nagpur, Maharashtra, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022


ABSTRACT:
A series of 24 condensed pyrimidine derivatives was synthesized via multistep reactions using microwave radiation and have opted to explore the possible inhibition mechanism via virtual analysis by using V life MDS. The synthesized compounds were characterized by spectroscopic analysis. All the synthesized compounds were found to show good in-silico binding analysis which indicated their potential to explore as good antimicrobial agents. All the synthesized derivatives were screened in-vitro for their antibacterial activity against two gram positive and gram negative bacteria. Among the compounds tested, SAKB2, SAKB7, SAKB8, SAKB9 SAKB10, SAKB11, SAKB12 and SAKB13derivatives exhibited potent antimicrobial activity.


Cite this article:
S. A. Khedkar, J. S. Patil, P. M. Sabale. Design and Synthesis, In Silico Analysis of Condensed Pyrimidine derivatives as Potent Antimicrobial Agents. Research Journal of Pharmacy and Technology. 2022; 15(6):2422-6. doi: 10.52711/0974-360X.2022.00403

Cite(Electronic):
S. A. Khedkar, J. S. Patil, P. M. Sabale. Design and Synthesis, In Silico Analysis of Condensed Pyrimidine derivatives as Potent Antimicrobial Agents. Research Journal of Pharmacy and Technology. 2022; 15(6):2422-6. doi: 10.52711/0974-360X.2022.00403   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-7


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