Author(s): Tathagata Roy, Payel Chakraborty, Rishita Roy Chowdhury, Tapan Kumar Chatterjee

Email(s): dr.tkchatterjee@jisuniversity.ac.in

DOI: 10.52711/0974-360X.2022.00454   

Address: Tathagata Roy1, Payel Chakraborty2, Rishita Roy Chowdhury2, Tapan Kumar Chatterjee3*
1Ph.D Research Scholar,Department of Pharmaceutical Technology, JIS University, Kolkata – 700109.
2Department of Pharmaceutical Technology, JIS University, Kolkata – 700109.
3Dean, JIS University, Kolkata – 700109.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022


ABSTRACT:
A network of proinflammatory cytokines plays an important role in the pathogenesis of osteoarthritis and rheumatoid arthritis. Among these pro-inflammatory cytokines, IL-1 superfamily cytokines like IL-1a, IL-1ß, IL-18, IL-33, IL-36 (a, ß, ?) play a pivotal role in the pathogenesis in both osteoarthritis & rheumatoid arthritis. IL-1ß produced by activated macrophages, activated chondrocytes, synoviocytes, osteoarthritic cartilage & subchondral bone. Various literature reveals that IL-1ß also plays deleterious effects in cartilage destruction in osteoarthritis & rheumatoid arthritis by increasing the release of various proteolytic enzymes like A Disintegrin-like and Metalloproteinases with Thrombospondin Motifs (ADAMTS) and matrix metalloproteinases (MMPs) like MMP-1, MMP-3 and MMP-13. Apart from this, IL-1ß also increases the expression of cathepsin B in chondrocytes that act as an important mediator of cartilage degradation. Novel anti-osteoarthritic drug diacerein shows pro-anabolic, anticatabolic and anti-inflammatory effects on synovial membrane and cartilage by its IL-1ß inhibitory effects. The aim of this review article is to discuss the role of diacerein in osteoarthritis and to explore the possible mechanism of action of diacerein in rheumatoid arthritis.


Cite this article:
Tathagata Roy, Payel Chakraborty, Rishita Roy Chowdhury, Tapan Kumar Chatterjee. Possible Beneficial Role of Novel Anti-Osteoarthritic Drug Diacerein in Rheumatoid Arthritis. Research Journal of Pharmacy and Technology. 2022; 15(6):2715-0. doi: 10.52711/0974-360X.2022.00454

Cite(Electronic):
Tathagata Roy, Payel Chakraborty, Rishita Roy Chowdhury, Tapan Kumar Chatterjee. Possible Beneficial Role of Novel Anti-Osteoarthritic Drug Diacerein in Rheumatoid Arthritis. Research Journal of Pharmacy and Technology. 2022; 15(6):2715-0. doi: 10.52711/0974-360X.2022.00454   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-58


REFERENCES:
1.    Ouhaddi Y, Najar M, Paré F, Lussier B, Urade Y, Benderdour M, Pelletier JP, Martel-Pelletier J, Fahmi H. L-PGDS deficiency accelerated the development of naturally occurring age-related osteoarthritis. Aging (Albany NY). 2020;12(24):24778-24797. doi: 10.18632/aging.202367
2.    Nees TA, Rosshirt N, Zhang JA, Reiner T, Sorbi R, Tripel E, Walker T, Schiltenwolf M, Hagmann S, Moradi B. Synovial cytokines significantly correlate with osteoarthritis-related knee pain and disability: inflammatory mediators of potential clinical relevance. Journal of clinical medicine. 2019;8(9):1343. https://doi.org/10.3390/jcm8091343
3.    Fokunang CN, Fokunang ET, Frederick K, Ngameni B, Ngadjui B. Overview of non-steroidal anti-inflammatory drugs (NSAIDS) in resource limited countries. MOJ Toxicol. 2018;4(1):5-13. DOI: 10.15406/mojt.2018.04.00081
4.    Amar S, Smith L, Fields GB. Matrix metalloproteinase collagenolysis in health and disease. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2017 Nov 1;1864(11):1940-51. DOI: 10.1016/j.bbamcr.2017.04.015
5.    Napoli D. Diacerein for use in treating psoriasis. Patent No. EP 1248 608 B1. 2003.
6.    Upadhyay R, swain TR, Mohapatra S, Upadhyay MR. Evaluation of Prophylactic Diacerein Treatment on Anti-Arthritic Activity in Freund’s Complete Adjuvant-Induced Arthritis in Rat Model. Journal of Clinical & Diagnostic Research. 2021;15(1): 14-19. DOI: 10.7860/JCDR/2021/47663.14461
7.    Almezgagi M, Zhang Y, Hezam K, Shamsan E, Gamah M, Al-Shaebi F, Abbas AB, Shoaib M, Saif B, Han Y, Jia R. Diacerein: Recent insight into pharmacological activities and molecular pathways. Biomedicine & Pharmacotherapy. 2020;131:110594. https://doi.org/10.1016/j.biopha.2020.110594  
8.    Pavelka K, Bruyere O, Cooper C, Kanis JA, Leeb BF, Maheu E, Martel-Pelletier J, Monfort J, Pelletier JP, Rizzoli R, Reginster JY. Diacerein: benefits, risks and place in the management of osteoarthritis. An opinion-based report from the ESCEO. Drugs & aging. 2016 Feb 1;33(2):75-85. DOI:10.1007/s40266-016-0347-4
9.    Akhter N, Khan AA, Ayaz SB, Akhter SM, L Afza A. Diacerein: A treatment option in painful primary knee. Pakistan Armed Forces Medical Journal. 2015 Feb 28;65(1):77-80.
10.    Min S, Wang C, Lu W, Xu Z, Shi D, Chen D, Teng H, Jiang Q. Serum levels of the bone turnover markers dickkopf-1, osteoprotegerin, and TNF-α in knee osteoarthritis patients. Clinical Rheumatology. 2017 Oct 1;36(10):2351-8. DOI: 10.1007/s10067-017-3690-x.
11.    Dinarello CA. Introduction to the interleukin-1 family of cytokines and receptors: Drivers of innate inflammation and acquired immunity. Immunological reviews. 2018 Jan;281(1):5-7. DOI: 10.1111/imr.12624
12.    Sokolove J, Lepus CM. Role of inflammation in the pathogenesis of osteoarthritis: latest findings and interpretations. Therapeutic advances in musculoskeletal disease. 2013 Apr;5(2):77-94. https://doi.org/10.1177/1759720X12467868
13.    Vincent TL. IL-1 in osteoarthritis: time for a critical review of the literature. F1000Research. 2019;1-8. https://doi.org/10.12688/f1000research.18831.1
14.    Wang F, Liu J, Chen X, Zheng X, Qu N, Zhang B, Xia C. IL-1β receptor antagonist (IL-1Ra) combined with autophagy inducer (TAT-Beclin1) is an effective alternative for attenuating extracellular matrix degradation in rat and human osteoarthritis chondrocytes. Arthritis Research & Therapy. 2019 Dec;21(1):1-4. https://doi.org/10.1186/s13075-019-1952-5
15.    Castañeda S, Vicente EF. Osteoarthritis: More than Cartilage Degeneration. Clinical Reviews in Bone and Mineral Metabolism. 2017 Jun 1;15(2):69-81. DOI :https://doi.org/10.1007/s12018-017-9228-6
16.    Bolívar BE, Vogel TP, Bouchier‐Hayes L. Inflammatory caspase regulation: maintaining balance between inflammation and cell death in health and disease. The FEBS Journal. 2019 Jul;286(14):2628-44. DOI: 10.1111/febs.14926.
17.    Fan Z, Bau B, Yang H, Soeder S, Aigner T. Freshly isolated osteoarthritic chondrocytes are catabolically more active than normal chondrocytes, but less responsive to catabolic stimulation with interleukin‐1β. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 2005 Jan;52(1):136-43. DOI: 10.1002/art.20725
18.    Sirikaew N, Chomdej S, Tangyuenyong S, Tangjitjaroen W, Somgird C, Thitaram C, Ongchai S. Proinflammatory cytokines and lipopolysaccharides up regulate MMP-3 and MMP-13 production in Asian elephant (Elephas maximus) chondrocytes: attenuation by anti-arthritic agents. BMC veterinary research. 2019 Dec;15(1):1-3.DOI: 10.1186/s12917-019-2170-8.
19.    Kang DG, Lee HJ, Lee CJ, Park JS. Inhibition of the expression of matrix metalloproteinases in articular chondrocytes by resveratrol through affecting nuclear factor-kappa B signaling pathway. Biomolecules & therapeutics. 2018 Nov;26(6):560. DOI: 10.4062/biomolther.2018.132.
20.    Amar S, Smith L, Fields GB. Matrix metalloproteinase collagenolysis in health and disease. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2017 Nov 1;1864(11):1940-51. DOI: 10.1016/j.bbamcr.2017.04.015.
21.    Pérez-García S, Carrión M, Gutiérrez-Cañas I, Villanueva-Romero R, Castro D, Martínez C, González-Álvaro I, Blanco FJ, Juarranz Y, Gomariz RP. Profile of matrix-remodeling proteinases in osteoarthritis: impact of fibronectin. Cells. 2020 Jan;9(1):40. DOI: 10.3390/cells9010040.
22.    Pittayapruek P, Meephansan J, Prapapan O, Komine M, Ohtsuki M. Role of matrix metalloproteinases in photoaging and photocarcinogenesis. International journal of molecular sciences. 2016 Jun;17(6): 868.DOI: 10.3390/ijms17060868
23.    Hu Q, Ecker M. Overview of MMP-13 as a Promising Target for the Treatment of Osteoarthritis. International Journal of Molecular Sciences. 2021 Jan;22(4):1742. https://doi.org/10.3390/ijms22041742
24.    Ali SY. The degradation of cartilage matrix by an intracellular protease. Biochemical Journal. 1964 Dec;93(3):611-8. DOI: 10.1042/bj0930611.
25.    Kozawa E, Cheng XW, Urakawa H, Arai E, Yamada Y, Kitamura S, Sato K, Kuzuya M, Ishiguro N, Nishida Y. Increased expression and activation of cathepsin K in human osteoarthritic cartilage and synovial tissues. Journal of Orthopaedic Research. 2016 Jan;34(1):127-34. https://doi.org/10.1002/jor.23005  
26.    Levy MT, McCaughan GW, Abbott CA, Park JE, Cunningham AM, Müller E, Rettig WJ, Gorrell MD. Fibroblast activation protein: a cell surface dipeptidyl peptidase and gelatinase expressed by stellate cells at the tissue remodelling interface in human cirrhosis. Hepatology. 1999 Jun;29(6):1768-78. https:// doi.org/10.1002/hep.510290631
27.    Pfander D, Heinz N, Rothe P, Carl HD, Swoboda B. Tenascin and aggrecan expression by articular chondrocytes is influenced by interleukin 1β: a possible explanation for the changes in matrix synthesis during osteoarthritis. Annals of the rheumatic diseases. 2004 Mar 1;63(3):240-4. http://dx.doi.org/10.1136/ard.2002.003749
28.    Sirikaew N, Chomdej S, Tangyuenyong S, Tangjitjaroen W, Somgird C, Thitaram C, Ongchai S. Proinflammatory cytokines and lipopolysaccharides up regulate MMP-3 and MMP-13 production in Asian elephant (Elephas maximus) chondrocytes: attenuation by anti-arthritic agents. BMC veterinary research. 2019 Dec;15(1):1-3.DOI: 10.1186/s12917-019-2170-8.
29.    Shakibaei M, John T, Seifarth C, Mobasheri AL. Resveratrol inhibits IL‐1β–induced stimulation of caspase‐3 and cleavage of PARP in human articular chondrocytes in vitro. Annals of the New York Academy of Sciences. 2007 Jan;1095(1):554-63. DOI: 10.1196/annals.1397.060.
30.    Lopez-Armada MJ, Carames B, Lires-Dean M, Cillero-Pastor B, Ruiz-Romero C, Galdo F, Blanco FJ. Cytokines, tumor necrosis factor-α and interleukin-1β, differentially regulate apoptosis in osteoarthritis cultured human chondrocytes. Osteoarthritis and cartilage. 2006 Jul 1;14(7):660-9. DOI: 10.1016/j.joca.2006.01.005.
31.    Pelletier JP, Yaron M, Haraoui B, Cohen P, Nahir MA, Choquette D, Wigler I, Rosner IA, Beaulieu AD. Efficacy and safety of diacerein in osteoarthritis of the knee: A double‐blind, placebo‐controlled trial. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 2000 Oct;43(10):2339-48. DOI: 10.1016/j.joca.2007.02.021.
32.    Felisaz N, Boumediene K, Ghayor C, Herrouin JF, Bogdanowicz P, Galerra P, Pujol JP. Stimulating effect of diacerein on TGF-β1 and β2 expression in articular chondrocytes cultured with and without interleukin-1. Osteoarthritis and Cartilage. 1999 May 1;7(3):255-64. DOI: 10.1053/joca.1998.0199
33.    Louthrenoo W, Nilganuwong S, Aksaranugraha S, Asavatanabodee P, Saengnipanthkul S, Thai Study Group. The efficacy, safety and carry-over effect of diacerein in the treatment of painful knee osteoarthritis: a randomised, double-blind, NSAID-controlled study. Osteoarthritis and cartilage. 2007 Jun 1;15(6):605-14.DOI: 10.1016/j.joca.2007.02.021.
34.    Martin G, Bogdanowicz P, Domagala F, Ficheux H, Pujol JP. Rhein inhibits interleukin-1β-induced activation of MEK/ERK pathway and DNA binding of NF-κB and AP-1 in chondrocytes cultured in hypoxia: a potential mechanism for its disease-modifying effect in osteoarthritis. Inflammation. 2003 Aug 1;27(4):233-46. https://doi.org/10.1023/A:1025040631514
35.    Kaur D, Kaur J, Kamal SS. Diacerein, its beneficial impact on chondrocytes and notable new clinical applications. Brazilian Journal of Pharmaceutical Sciences. 2018;54(4). https://doi.org/10.1590/s2175-97902018000417534
36.    Li J, Ny A, Leonardsson G, Nandakumar KS, Holmdahl R, Ny T. The plasminogen activator/plasmin system is essential for development of the joint inflammatory phase of collagen type II-induced arthritis. The American Journal of Pathology. 2005 Mar 1;166(3):783-92. DOI: 10.1016/S0002-9440(10)62299-7.
37.    Nonaka TO, Kikuchi HI, Ikeda TE, Okamoto YO, Hamanishi CH, Tanaka SE. Hyaluronic acid inhibits the expression of u-PA, PAI-1, and u-PAR in human synovial fibroblasts of osteoarthritis and rheumatoid arthritis. The Journal of Rheumatology. 2000 Apr;27(4):997-1004.
38.    Shakibaei M, Schulze-Tanzil G, John T, Mobasheri A. Curcumin protects human chondrocytes from IL-1β-induced inhibition of collagen type II and β1-integrin expression and activation of caspase-3: an immunomorphological study. Annals of Anatomy-Anatomischer Anzeiger. 2005 Nov 2;187(5-6):487-97. DOI: 10.1016/j.aanat.2005.06.007.
39.    Mengshol JA, Vincenti MP, Coon CI, Barchowsky A, Brinckerhoff CE. Interleukin‐1 induction of collagenase 3 (matrix metalloproteinase 13) gene expression in chondrocytes requires p38, c‐Jun N‐terminal kinase, and nuclear factor κB: differential regulation of collagenase 1 and collagenase 3. Arthritis & Rheumatism: Official Journal of the American College of Rheumatology. 2000 Apr;43(4):801-11. DOI: 10.1002/1529-0131(200004)43:4<801
40.    Vincenti MP, Brinckerhoff CE. Transcriptional regulation of collagenase (MMP-1, MMP-13) genes in arthritis: integration of complex signaling pathways for the recruitment of gene-specific transcription factors. Arthritis Research & Therapy. 2002 Apr 1;4(3):157. https://doi.org/10.1186/ar401
41.    Szopińskal et al. The pathogenesis of rheumatoid arthritis in radiological science.Part I: Formation of inflammatory infiltrates within the synovial membrane. Journal of Ultrasonography. 2012 Jun; 12(49): 202–213. DOI: 10.15557/JoU.2012.0007
42.    Van't Hof RJ, Hocking L, Wright PK, Ralston SH. Nitric oxide is a mediator of apoptosis in the rheumatoid joint. Rheumatology. 2000 Sep 1;39(9):1004-8. DOI: 10.1093/rheumatology/39.9.1004

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

0.38
2018CiteScore
 
56th percentile
Powered by  Scopus


SCImago Journal & Country Rank


Recent Articles




Tags


Not Available