Author(s):
Tathagata Roy, Payel Chakraborty, Rishita Roy Chowdhury, Tapan Kumar Chatterjee
Email(s):
dr.tkchatterjee@jisuniversity.ac.in
DOI:
10.52711/0974-360X.2022.00454 
Address:
Tathagata Roy1, Payel Chakraborty2, Rishita Roy Chowdhury2, Tapan Kumar Chatterjee3*
1Ph.D Research Scholar,Department of Pharmaceutical Technology, JIS University, Kolkata – 700109.
2Department of Pharmaceutical Technology, JIS University, Kolkata – 700109.
3Dean, JIS University, Kolkata – 700109.
*Corresponding Author
Published In:
Volume - 15,
Issue - 6,
Year - 2022
ABSTRACT:
A network of proinflammatory cytokines plays an important role in the pathogenesis of osteoarthritis and rheumatoid arthritis. Among these pro-inflammatory cytokines, IL-1 superfamily cytokines like IL-1a, IL-1ß, IL-18, IL-33, IL-36 (a, ß, ?) play a pivotal role in the pathogenesis in both osteoarthritis & rheumatoid arthritis. IL-1ß produced by activated macrophages, activated chondrocytes, synoviocytes, osteoarthritic cartilage & subchondral bone. Various literature reveals that IL-1ß also plays deleterious effects in cartilage destruction in osteoarthritis & rheumatoid arthritis by increasing the release of various proteolytic enzymes like A Disintegrin-like and Metalloproteinases with Thrombospondin Motifs (ADAMTS) and matrix metalloproteinases (MMPs) like MMP-1, MMP-3 and MMP-13. Apart from this, IL-1ß also increases the expression of cathepsin B in chondrocytes that act as an important mediator of cartilage degradation. Novel anti-osteoarthritic drug diacerein shows pro-anabolic, anticatabolic and anti-inflammatory effects on synovial membrane and cartilage by its IL-1ß inhibitory effects. The aim of this review article is to discuss the role of diacerein in osteoarthritis and to explore the possible mechanism of action of diacerein in rheumatoid arthritis.
Cite this article:
Tathagata Roy, Payel Chakraborty, Rishita Roy Chowdhury, Tapan Kumar Chatterjee. Possible Beneficial Role of Novel Anti-Osteoarthritic Drug Diacerein in Rheumatoid Arthritis. Research Journal of Pharmacy and Technology. 2022; 15(6):2715-0. doi: 10.52711/0974-360X.2022.00454
Cite(Electronic):
Tathagata Roy, Payel Chakraborty, Rishita Roy Chowdhury, Tapan Kumar Chatterjee. Possible Beneficial Role of Novel Anti-Osteoarthritic Drug Diacerein in Rheumatoid Arthritis. Research Journal of Pharmacy and Technology. 2022; 15(6):2715-0. doi: 10.52711/0974-360X.2022.00454 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-58
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