Author(s): Benni Iskandar, Gressy Novita, Fiona Fitri Annisa, Leny, Ihsanul Hafiz, Meircurius D.C. Surboyo, Ching-Kuo Lee

Email(s): leny@helvetia.ac.id

DOI: 10.52711/0974-360X.2022.00452   

Address: Benni Iskandar1,4, Gressy Novita1, Fiona Fitri Annisa1, Leny2*, Ihsanul Hafiz2, Meircurius D.C. Surboyo3, Ching-Kuo Lee4
1Department of Pharmaceutical Technology, Sekolah Tinggi Ilmu Farmasi Riau, Pekanbaru, Indonesia.
2Faculty of Pharmacy and Health, Institut Kesehatan Helvetia, Medan, Indonesia.
3Department of Oral Medicine, Faculty of Dental Medicine, Universitas Airlangga, Surabaya, Indonesia.
4School of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022


ABSTRACT:
Moringa leaves contains flavonoids which has the activity of free radical scavenging or as an antioxidant. The purpose of this study was to formulate the water insoluble extract of Moringa leaves into emulgel dosage forms in various concentrations to produce a stable preparation during storage and have antioxidant activity. The formulation of the emulgel preparation was made by varying the concentration of the ethanol extract of Moringa leaves at 0%(F0), 0.5%(FI), 1%(FII), and 2%(FIII). The study examined the emulgel preparation including organoleptic test, irritation test, pH test, homogeneity test, emulsion type test, spreadability test, freeze and thaw stability and antioxidant properties by using DPPH method. The results showed that all emulgel preparations were stable during storage, did not irritate, pH value between 5.50-6.04, homogeneous preparation, emulsion type was oil on water phase (o/w), spreadability between 3.2-3.9cm, IC50 from ethanol extract of Moringa leaves was 135.539ppm. For emulgel preparation, FIII formulation showed best activity compared to another formula in its capacity which was 192.48 ppm for 1st week storage and 292.94ppm for the 8th week storage. The conclusion of this study shows that emulgel containing Moringa leaf extract has antioxidant activity and stable in physical properties during storage.


Cite this article:
Benni Iskandar, Gressy Novita, Fiona Fitri Annisa, Leny, Ihsanul Hafiz, Meircurius D.C. Surboyo, Ching-Kuo Lee. Evaluation of Physical Quality and Antioxidant Activity of Ethanol Extract of Moringa Leaves (Moringa oleifera LAM) Formulated in Emulgel Preparation. Research Journal of Pharmacy and Technology. 2022; 15(6):2703-8. doi: 10.52711/0974-360X.2022.00452

Cite(Electronic):
Benni Iskandar, Gressy Novita, Fiona Fitri Annisa, Leny, Ihsanul Hafiz, Meircurius D.C. Surboyo, Ching-Kuo Lee. Evaluation of Physical Quality and Antioxidant Activity of Ethanol Extract of Moringa Leaves (Moringa oleifera LAM) Formulated in Emulgel Preparation. Research Journal of Pharmacy and Technology. 2022; 15(6):2703-8. doi: 10.52711/0974-360X.2022.00452   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-56


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