Author(s): Avbunudiogba John Afokoghene, Aumade Daguo

Email(s): Email ID Not Available

DOI: 10.52711/0974-360X.2022.00451   

Address: Avbunudiogba John Afokoghene*, Aumade Daguo
Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Delta State University, Abraka, Delta State, Nigeria.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022

The major reason for development of new drug delivery system is based largely on promoting therapeutic outcome and minimizing toxic effect of a drug by increasing the amount and persistence of a drug in target cells areas, while reducing exposure of the drug to non-target cells. In this study, Grewia spp gum obtained from Grewia spp pods was extracted and used as binder and release retardant in the formulation of controlled release theophylline tablets. A total of six (6) batches of the tablets were produced with carried concentrations of the test gum by wet granulation technique. To produce the tablets, various granules were formulated via wet granulation and characterized by measuring flow and packing properties. Granules with adequate flow properties were compressed to tablets. Tablets so formed were evaluated for hardness, percentage friability, weight variability and drug release profiles. The percentage yield was 18.64% and the pH of the test gum was 6.15. The angle of repose, bulk density, tapped density and Carr’s index of the formulated granules ranged from 22.48±0.00 to 24.90±0.00°, 0.53±0.03 to 0.67±0.00g/ml, 0.67±0.02 to 0.82±0.00g/ml and 18.29±0.00 to 22.06±0.26% respectively. Resultant tablets hardness values of 3.69±0.45 to 13.39±0.65kgF and friability percentage of 0.40± 0.00 to 2.56%±0.01% were also obtained. The formulated theophylline granules showed good flow properties and compressibility. Thus, the study revealed that the test gum has comparable binding effect to Eudragit RS 100 at a ratio of 2:1. We recommend further studies to rule out any interaction of Grewia spp gum with theophylline in controlled release theophylline tablets.

Cite this article:
Avbunudiogba John Afokoghene, Aumade Daguo. Formulation and Evaluation of Controlled Release Theophylline Tablets using Grewia spp Gum as Binder. Research Journal of Pharmacy and Technology. 2022; 15(6):2697-2. doi: 10.52711/0974-360X.2022.00451

Avbunudiogba John Afokoghene, Aumade Daguo. Formulation and Evaluation of Controlled Release Theophylline Tablets using Grewia spp Gum as Binder. Research Journal of Pharmacy and Technology. 2022; 15(6):2697-2. doi: 10.52711/0974-360X.2022.00451   Available on:

1.    Bhandwadkar MJ, Kalbhare SB, Pawar RK, Pawar PP, Thorat AT. A comprehensive Review on Natural polymer: Application in Pharmaceutical formulations. International Journal of Creative Research Thoughts. 2020; 8(2): 1168-1177.
2.    Goswani S, Naik S. Natural gums and its pharmaceutical application. Journal of Scientific and Innovative Research. 2014; 3(1): 112-124.
3.    Lankalapalli S, Sandhata D. A Review on natural gums and their use as pharmaceutical excipients. International Journal of Pharmaceutical Sciences and Research. 2019; 10(12): 5274-5283.
4.    Jani GK, Shah DP, Prajapatia VD, Jain VC. Gums and mucilages versatile excipients for Pharmaceutical formulations. Asian Journal of Pharmaceutical Sciences. 2009; 4: 308-322.
5.    Pal RS, Pal Y, Wal A, Wal P. Current Review on plant based Pharmaceutical excipients. Open Medicine Journal. 2019; 6: 1-5.
6.    Evans WC. Trease and Evans: Pharmacognosy. Harcourt Brace & Co., Asia Pvt. Ltd, Singapore. 1996; 14th ed: pp. 196, 208, 209, 213-215, 462, 555.
7.    Patil SV, Ghatage SL, Navale SS, Mujawar NK. Natural binders in tablets formulation. International Journal of PharmTech Reseach. 2014; 6(3): 1070-1073.
8.    Enauyatifard R, Azadbakht M, Fadakar Y. Assessment of Ferula gummosa gum as a binding agent in tablet formulations. Acta Poloniae Pharmaceutica - Drug Research. 2012; 69: 291-298.
9.    Oyi AR, Olayemi OJ, Allagah TS. Comparative binding effects of wheat, rice and maize starches in chloroquine phosphate tablet formulation. Researc Journal of Applied. Sciences, Engineering and Technology. 2009; 1: 77-80.
10.    Nayak K; Singhai AK, Saraogi GK, Sharma S, Mishra MK. Formulation and evaluation of sustained release matrix tablets of glibenclamide. World Journal of Pharmaceutical Research. 2016; 5(11): 974-988.
11.    Alhalmi A, Altowairi M, Saeed O, Alzubaidi N, Almoiligy M, Abdulmalik W. World Journal of Pharmacy and Pharmaceutical Sciences. 2018; 7(6): 1470-1486.
12.    Haritha B. A Review on Evaluation of Tablets. Journal of Formulation Science and Bioavailability. 2017; 1(1): 1-5.
13.    Potnuri NR, Devala RG, Srinivasa RA, Gnaneshwar RM, Shashidhar RS. Effects of bunders, lubricants and fillers on drug release from Diltiazem hydrochloride Bi-layered matrix tablets obtained by direct compression and wet granulation technique. International Journal of Pharmacy. 2012; 2(1): 117-128
14.    Gunatilake SK, Samaratunga SS, Adekola FA. Effects of binder on the physico-chemical properties and the quality of paracetamol tablets. Der Pharma Chemica. 2016; 8(4): 237-242.
15.    Barnes PJ. Theophylline. Pharmaceuticals. 2010; 3: 725-747.
16.    Barnes PJ. Theophylline. American Journal of Respiratory and Critical Care Medicine. 2013; 188: 901- 906.
17.    Nokhodchi A, Raja S, Patel P, Asare-Addo K. The role of Oral Controlled Release Matrix Tablets in Drug Delivery Systems. Bioimpacts. 2012; 2(4): 1-13.
18.    Hareesh RM, Sambasiva RA. A Review of Oral Matrix Type Controlled Drug Delivery System. Indo-American Journal of Pharmaceutical Sciences. 2015; 2(5): 937-946.
19.    Sowdhamini M, Sirisha B, Pratyusha A, Rao VU. An Overview on Natural10 Polymers as Pharmaceutical Excipients. Intercontinental Journal of Pharmaceutical Investigations and Research. 2015; 2(3): 35-48.
20.    Khan S, Parvez N, Sharma PK. Novel Natural Mucoadhesive Polymers. World Journal of Pharmacy and Pharmaceutical Sciences. 2015; 4(12): 374-388.
21.    Avbunudiogba JA, Okuntarami MD, Adjene JO. Evaluation of the emulsifying properties of Grewia spp. Journal of Bio Innovation. 2020; 9(5): 910-919.
22.    Uzondu ALE, Avbunudiogba JA, Alalor C, Okafo SE. Powder Densification. In: Uzondu ALE(Ed); Laboratory Manual for Solid Dosage Technology. Delta State University press, Abraka: 2015; 1st ed: pp 14-16.
23.    Hima PV, Akshay PR, Janki BB. Formulation, Development and Evaluation of Doxophylline Sustained Release Matrix Tablet. International Research Journal of Pharmacy. 2011; 2(12): 204-207.
24.    Sun J, Wang F, Sui Y, She Z, Zhai W, Wang C, Deng Y. Effect of particle size on solubility, dissolution rate, and oral bioavailability: Evaluation using coenzyme Q10 as naked Nano crystals. International Journal of Nano Medicine. 2012; 7: 5733 – 5744.
25.    Wang H, Li Q, Reyes S, Zhang J, Xie L, Melendez V, Hickman M, Kozar MP (2013). Formulation and particle size reduction improve bioavailability of poorly water – soluble compounds with antimalarial activity. Malaria Research and treatment. Vol 2013, Article ID 769234, 10 pages. Htt:// 1155/2013/769234.
26.    Eichie FE, Kudehinbu AD. Effect of particle size of granules on some mechanical properties of paracetamol tablets. African Journal of Biotechnology. 2009; 8(21): 5913 – 5916.
27.    Olsson H, Nyström C. Assessing tablet bond types from structural features that affect tablet tensile strength. Pharmaceutical Research. 2001; 18(2): 203 – 210.
28.    Gaikwad VL, Bhatia MS, Singhvi IJ. Effect of polymeric properties on physical characteristics of fast disintegrating ibuprofen tablets: A statistical approach. Der Pharmacia. 2013; 5(3): 140 – 147.

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