Author(s): K. Tirumala Devi, B. S. Venkateswarlu, D. Umamaheswari, G. R. Vijay Sankar, N. Lakshmi Prasanthi

Email(s): ktirumaladevi89@gmail.com

DOI: 10.52711/0974-360X.2022.00441   

Address: K. Tirumala Devi1*, B. S. Venkateswarlu², D. Umamaheswari³, G. R. Vijay Sankar2, N. Lakshmi Prasanthi4
1Department of Pharmaceutics, M.A.M College of Pharmacy, Kesanupalli, Guntur, Andhra Pradesh, India.
2Department of Pharmaceutics, Vinayaka Missions College of Pharmacy, Salem, Tamilnadu.
3Department of Pharmaceutical Chemistry, Vinayaka Missions College of Pharmacy, Salem, Tamilnadu.
4Department of Pharmaceutical Sciences, Vignan’s Foundation for Science, Technology and Research, Vadlamudi, Guntur, Andhra Pradesh, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022


ABSTRACT:
This research describes the preparation of ornidazole (ORZ) polymeric nanoparticles by using chitosan as polymer for colon-specific delivery. The polymeric nanoparticles were prepared by the ionic gelation method. The nanoparticles were evaluated for their in vitro drug release properties. Scanning electron microscopy was used for morphology observation. The nanoparticles exhibited mucoadhesive properties, which diminished with increasing drug content. The nanoparticles with a particle size range between 180 and 280?nm exhibited excellent mucoadhesive properties. The results shown that the formulated nanoparticles have succeeded in controlling the release of (ORZ) over a 14-hr period. In conclusion, the release of ORZ was found to be dependent upon the composition of the nanoparticles, the ratio of the components and possible particle size, as well as bioadhesive ability.


Cite this article:
K. Tirumala Devi, B. S. Venkateswarlu, D. Umamaheswari, G. R. Vijay Sankar, N. Lakshmi Prasanthi. Design and Development of Ornidazole Loaded Polymeric Nanoparticles. Research Journal of Pharmacy and Technology. 2022; 15(6):2639-4. doi: 10.52711/0974-360X.2022.00441

Cite(Electronic):
K. Tirumala Devi, B. S. Venkateswarlu, D. Umamaheswari, G. R. Vijay Sankar, N. Lakshmi Prasanthi. Design and Development of Ornidazole Loaded Polymeric Nanoparticles. Research Journal of Pharmacy and Technology. 2022; 15(6):2639-4. doi: 10.52711/0974-360X.2022.00441   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-45


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