Author(s): Sravanthi P., Ramya Krishna P.S., Narahari N. Palei, Sannidhi Nagarjuna


DOI: 10.52711/0974-360X.2022.00400   

Address: Sravanthi P.1, Ramya Krishna P.S.2, Narahari N. Palei3, Sannidhi Nagarjuna2
1Neermala College of Pharmacy, Kadapa, Andhra Pradesh, India.
2Raghavendra Institute of Pharmaceutical Education and Research, Anantapur, Andhra Pradesh, India.
3School of Pharmacy, The Neotia University, Sarisha, Diamond Harbour Road, West Bengal, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022

Objective: The objective of this study was to investigate the antihyperlipidemic activity of Feronia limonia leaves extract in rats. Methods: Hyperlipidemia was induced in rats by feeding high fat diet (HFD) for four successive weeks and Triton X 100(400mg/kg, i.p.) for 24 hours. From 15th to 30th day, extract (250 and 500mg/kg, p.o) and atorvastatin (20mg/kg, p.o.) per se were administered 2 hours prior to feeding rats with high fat diet (HFD). Blood samples of all rats were collected and estimated biochemical parameters on the last day of treatment i.e., 30th day for HFD, and after 24 hours for of Triton X 100 induced hyperlipidaemia using standard diagnostic kits. White adipose tissue obtained from all rats were fixed in 10% formo-saline and analyzed for adipocyte size. Results and Discussion: HFD or Triton X 100 significantly increased serum total cholesterol, triglycerides, LDL-c, and decreased HDL-c concentration. The Extract (250mg/kg, p.o. and 500mg/kg, p.o.) significantly reversed HFD-induced and Triton X 100 induced hyperlipidemia. The adipose tissue of animals which were treated with MEFL showed significant and dose-related decrease in cell size when compared to animals of control group. Conclusions: It can be concluded that extact showed significant anti hyperlipidemic activity in rats and hence it could be a possible herbal medicine for the treatment of hyperlipidemia.

Cite this article:
Sravanthi P., Ramya Krishna P.S., Narahari N. Palei, Sannidhi Nagarjuna. Antihyperlipidemic Activity of Feronia limonia Leaves Extract against Triton X 100 and High Fat Induced Hyperlipidemic in Rats. Research Journal of Pharmacy and Technology. 2022; 15(6):2407-2. doi: 10.52711/0974-360X.2022.00400

Sravanthi P., Ramya Krishna P.S., Narahari N. Palei, Sannidhi Nagarjuna. Antihyperlipidemic Activity of Feronia limonia Leaves Extract against Triton X 100 and High Fat Induced Hyperlipidemic in Rats. Research Journal of Pharmacy and Technology. 2022; 15(6):2407-2. doi: 10.52711/0974-360X.2022.00400   Available on:

1.    Lopes RHO, Macorini LFB, Antunes KA, De Toledo Espindola PP, Alfredo TM, Da Rocha PS, Pereira ZV, Dos Santos EL, Souza KD. Antioxidant and Hypolipidemic Activity of the Hydroethanolic Extract of Curatella americana L. Leaves. Oxidative Medicine and Cellular Longevity. 2016; 2016:1- 6.
2.    Jaybhaye M, Jagtap P, Unadle V, Shinde S, Bhagvat G, porwal A, Jagtap V. Evaluation of Hypolipidemic Potential of a Polyherbal Formulation in Experimental Rats. Research Journal of Pharmacy and Technology. 2018; 11(11): 5037-5041.
3.    Intekhab J, Aslam M. Isolation of a flavonoid from Feronia limonia. Journal of Saudi Chemical Society. 2009; 13(3): 295-298.
4.    Momin MAM, Bellah SF, Khan MR, Md. Raju IH, Rahman MM, Begum AA. Phytopharmacological evaluation of ethanolic extract of Feronia limonia leaves. American Journal of Scientific and Industrial Research. 2013; 4(5): 468-472.
5.    Nwauche KT, Monago CC, Anacletus FC. Management of diabetic induced hyperlipidemia with combined therapy of reducdyn and metformin in streptozotocin induced diabetic male rats. Research Journal of Pharmacy and Technology. 2014; 7(9): 1041-1045.
6.    Mamun MA, Hasan N, Shirin F, Belal MH, Khan MAJ, Tasnin MN, Islam MD, Islam A, Ara T, Karim MRU, Rahman KZ, Rahman MM, Khan MMH, Karim MR, Islam MA. Antihyperglycemic and antihyperlipidemic activity of ethanol extract of garlic (Allium sativum) in streptozotocin-induced diabetic mice. International Journal of Medical and Health Research. 2017; 3(2): 63-66.
7.    Gundamaraju R, Hwi KK, Singla RK, Vemuri RC, Mulapalli SB. Antihyperlipidemic potential of Albizia amara (Roxb) Boiv. bark against Triton X-100 induced hyperlipidemic condition in rats. Pharmacognosy Research. 2014; 6(4): 267-273.
8.    Dhingra D, Lamba D, Kumar R, Nath P, Gauttam S. Antihyperlipidemic Activity of Aloe succotrina in Rats: Possibly Mediated by Inhibition of HMG-CoA Reductase. ISRN Pharmacology. 2014; 2014: 1-9.
9.    Kashnia AR, Senthilkumar KL, Karthiyayini T, Senthilkumar K. Anti-Hyperlipidemic Activity of Ethanolic and Aqueous Extracts of Flowers of Nymphaea nouchali (Burm.) F. Research Journal of Pharmacology and Pharmacodynamics. 2009; 1(1): 13-15.
10.    Monago CC, Gozie GC, Joshua PE. Antidiabetic and Antilipidemic Effects of Alkaloidal Extract of Emilia sonchifolia in Rat. Research Journal of Science and Techcnology.2010; 2(3): 51-56.
11.    Kamal F, Shahzad M, Ahmad T, Ahmed Z, Tareen RB, Naz R, Ahmad A. Antihyperlipidemic effect of Pistacia khinjuk. Biomedicine and Pharmacotherapy. 2017; 96: 695-699.
12.    Khare S, Khare P. Analgesic activity of ethanol extract of Feronia limonia (l.) swingle leaves. International Journal of Pharmaceutical Sciences and Research. 2011; 2(2): 351-356.
13.    Sowmya A, Ananthi T. Hypolipidemic activity of Mimosa pudica Linn on Butter Induced Hyperlipidemia in Rats. Asian Journal of Research in Pharmaceutical Sciences.2011; 1(4): 123-126.
14.    Bahar E, Siddika MS, Nath B, Yoon H. Evaluation of In vitro Antioxidant and In vivo Antihyperlipidemic Activities of Methanol Extract of Aerial Part of Crassocephalum crepidioides (Asteraceae) Benth S Moore. Tropical Journal of Pharmaceutical Research. 2016; 15(3): 481-488.
15.    Mopuri R, Ganjayi M, Banavathy KS, Parim BN, Meriga B. Evaluation of anti-obesity activities of ethanolic extract of Terminalia paniculata bark on high fat diet-induced obese rats. BMC Complementary and Alternative Medicine. 2015; 15: 76.
16.    Nishida M, Kondo M, Shimizu T, Saito T, Sato S, Hirayama M, Konishi T, Nishida H. Antihyperlipidemic effect of Acanthopanax senticosus Harms leaves in high-fat-diet fed mice. Journal of the Science of Food and Agriculture. 2016; 96(11): 3717-3722.
17.    Dominic Amalraj A, Parkavi C, Murugaiah K, Dhanaraj TS. Hypolipidemic Activity of Cyperous rotundus on CCl4 Induced Dyslipidemia in Rats. Asian Journal of Pharmacy and Technology.2012; 2(2): 51-53.
18.    Tacherfiout M, Petrov PD, Mattonai M, Ribechini E, Ribot J, Bonet ML, Khettal B. Antihyperlipidemic effect of a Rhamnus alaternus leaf extract in Triton-induced hyperlipidemic rats and human HepG2 cells. Biomedicine and Pharmacotherapy. 2018; 101: 501-509.
19.    Liu Y, Cao Y, Fang S, Wang T, Yin Z, Shang X, Yang W, Fu X. Antidiabetic effect of Cyclocarya paliurus leaves depends on the contents of antihyperglycemic flavonoids and antihyperlipidemic triterpenoids. Molecules. 2018; 23: 1042.
20.    Saleem U, Riaz S, Ahmad B, Mohammad S. Pharmacological screening of Trachyspermum ammi for antihyperlipidemic activity in Triton X-100 induced hyperlipidemia rat model. Pharmacognosy Research. 2017; 9(5): 34-40.
21.    Adigun NS, Oladiji AT, Ajiboye TO. Antioxidant and anti-hyperlipidemic activity of hydroethanolic seed extract of Aframomum melegueta K. Schum in Triton X-100 induced hyperlipidemic rats. South African Journal of Botany. 2016; 105: 324-332.
22.    Sahu J, Patel PK, Dubey B. Effects of Methanolic Extracts of Quisqualis indica (Aerial Parts) on Passive Smoking Induced Hyperlipidemia in Rats. Asian Journal of Pharmacy and Technology. 2013; 3(1): 26-29.
23.    Chigozie IJ, Chidinma IC. Hypoglycemic, hypocholesterolemic, anti-anemic and ocular-protective effects of an aqueous extract of the rhizomes of Sansevieria liberica Gérôme and Labroy (Agavaceae) on alloxan induced diabetic Wistar rats. Asian Journal of Pharmacy and Technology. 2011; 1(4): 137-148.
24.    Ikewuchi JC, Ikewuchi CC. Hypocholesterolaemic Effect of Aqueous Extract of Acalypha wilkesiana ‘Godseffiana’ Muell Arg on Rats Fed Egg Yolk Supplemented Diet: Implications for Cardiovascular Risk Management. Research Journal of Science and Techcnology. 2010; 2(4): 78-81.

Recomonded Articles:

Research Journal of Pharmacy and Technology (RJPT) is an international, peer-reviewed, multidisciplinary journal.... Read more >>>

RNI: CHHENG00387/33/1/2008-TC                     
DOI: 10.5958/0974-360X 

56th percentile
Powered by  Scopus

SCImago Journal & Country Rank

Recent Articles


Not Available