Casimir Adade Adade, Amine Cheikh, Hafid Mefetah, Amina Kili, Laila Hessissen, Mustapha Bouatia
Casimir Adade Adade*1, Amine Cheikh2, Hafid Mefetah3, Amina Kili4, Laila Hessissen4, Mustapha Bouatia1,3
1Faculty of Medicine and Pharmacy of Rabat, Mohamed V University, 10170 Rabat, Morocco.
2Department of Pharmacy, Faculty of Pharmacy, Abulcasis University, 10000 Rabat, Morocco.
3Department of Pharmacy, Pediatric Hospital, 10170 Rabat, Morocco.
4Pediatric Hematology and Oncology Center, Mohamed V University, 10170 Rabat, Morocco.
Volume - 15,
Issue - 6,
Year - 2022
Objective: To determine the incidence and frequency of adverse drug reactions (ADRs) induced by cancer chemotherapy in pediatric inpatients. Patients and methods: This was a six-month prospective observational study in the pediatric hematology-oncology department of the children's hospital of Rabat. This study took into account ADRs manifested by in inpatient children and undergoing cancer chemotherapy. A modified version of the Moroccan Poison Control and Pharmacovigilance Centre's notification form was used to collect demographic, clinical, cancer treatment and ADR-related data. The causality, severity and preventability were assessed for each adverse event. Results: 106 patients out of 118 followed have developed a total of 266 ADRs. The most frequent ADRs were anemia (14.3%), infections (9.4%), leukopenia (8.6%) and fever (8.3%). Vincristine (16.3%), etoposide (14%) and cytarabine (13%) were the most frequently administered products. Cytarabine followed by etoposide were the drugs most involved in ADRs. The majority of ADRs (55.6%) were probable according to the WHO method of causality assessment. Conclusion: Cancer chemotherapy is associated with a high risk of developing ADRs, particularly hematological ADRs in children. Pediatric patients receiving cytarabine and daunorubicin combinations and regimens including anthracyclines should receive more attention. Risk management plans need to be implemented by health care teams in this area.
Cite this article:
Casimir Adade Adade, Amine Cheikh, Hafid Mefetah, Amina Kili, Laila Hessissen, Mustapha Bouatia. Adverse effects of Anticancer Chemotherapy in Childhood Cancer: A Prospective Study in a Moroccan hospital. Research Journal of Pharmacy and Technology. 2022; 15(6):2559-4. doi: 10.52711/0974-360X.2022.00428
Casimir Adade Adade, Amine Cheikh, Hafid Mefetah, Amina Kili, Laila Hessissen, Mustapha Bouatia. Adverse effects of Anticancer Chemotherapy in Childhood Cancer: A Prospective Study in a Moroccan hospital. Research Journal of Pharmacy and Technology. 2022; 15(6):2559-4. doi: 10.52711/0974-360X.2022.00428 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-32
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