Author(s): Rajesh. R, Selvakumar. K

Email(s): rajeshr@acharya.ac.in

DOI: 10.52711/0974-360X.2022.00424   

Address: Rajesh. R*, Selvakumar. K
Department of Pharmaceutical Analysis, Acharya & BM Reddy College of Pharmacy, Soldevanahalli, Hessarghatta Main Road, Bengaluru - 560107.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022


ABSTRACT:
Helminthiasis is a major public health concern and in developing nations, this leads to the prevalence of pneumonia, malnutrition, eosinophilia and anaemia. In current research, the development of resistance to anthelmintics has led to the evaluation of the alternative source of medicinal plants as an anthelmintic drug. Methanol and aqueous extracts of Lannea coromandelica bark were evaluated at various concentration levels of 10, 25 and 50mg/ml for in-vitro anthelmintic activity against Pheretima posthuma and Ascardia galli obtained from soil. Results were reported in paralysis time and worm death time in minutes. As a reference standard, piperazine citrate was used (15mg/ml). In both extracts, activity based on dose was observed. The result revealed that the extract of methanol (MELC) is more active than the aqueous extract (AELC) and can therefore be useful as anthelmintics. From these observations, it was concluded that the anthelmintic activity observed due to the presence of secondary metabolites such as flavanoids, saponins, tannins, alkaloids and terpenoids. Our results report for the first time that Lannea coromandelica bark extracts have therapeutic values with prominent anthelmintic properties.


Cite this article:
Rajesh. R, Selvakumar. K. Evaluation of in vitro Anthelmintic activity of Lannea coromandelica (Houtt.) Merr. against Pheretima posthuma and Ascardia galli. Research Journal of Pharmacy and Technology. 2022; 15(6):2539-2. doi: 10.52711/0974-360X.2022.00424

Cite(Electronic):
Rajesh. R, Selvakumar. K. Evaluation of in vitro Anthelmintic activity of Lannea coromandelica (Houtt.) Merr. against Pheretima posthuma and Ascardia galli. Research Journal of Pharmacy and Technology. 2022; 15(6):2539-2. doi: 10.52711/0974-360X.2022.00424   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-28


REFERENCES:
1.    Neil Mabott A. The influence of parasite infections on host immunity to co-infection with other pathogens. Front Immunol. 2018; 9:2579. doi.org/10.3389/fimmu.2018.02579
2.    Swathi H. Shekshavalli T. Invitro evaluation of anthelmintic activity of Rhus mysorensis leaves. Res. J. pharmacology and pharmacodymanics. 2016; 8(3):115-117. doi.org/10.5958/2321-5836.2016.00021.5
3.    Singh AK. Amit kumar S. Madan S. Vijay KY. Nidhi S. In vitro anthelmitic activity of stem bark extracts of Saraca indica Roxb. Against Pheretima posthuma. Asian J. Research Chem. 2014; 7(2):141-143. https://ajrconline.org/AbstractView.aspx?PID=2014-7-2-6
4.    Mulla WA. Thorat VS. Patil RV. Burade KB. Anthelmintic activity of leaves of Alocasia indica Linn. International Journal of Pharm.Tech. Research. 2010; 2(1):26. https://www.cabdirect.org/cabdirect/abstract/20103302236
5.    Tripathi AK. Verma RK. Gupta AK. Gupta MM. Khanuja SP. Quantitative determination of phyllanthin and hypophyllanthinin Phyllanthus species by high-performance thin layer chromatography, Phytochem Anal. 2006; 17(6):394-397. doi.org/10.1002/pca.936
6.    Nadkarnis KM. Indian Materia Medica. Vol I. Popular Prakashan Pvt. Ltd., Mumbai. 1976; 867-868.
7.    Sujogya KP. Laxmipriya P. Pieter L. Maoxuan L. Johan N. Walter L. Antimicrobial, Anthelmintic, and Antiviral Activity of Plants Traditionally Used for Treating Infectious Disease in the Similipal Biosphere Reserve, Odisha, India. Front. Pharmacol. 2017; 8:658. doi: 10.3389/fphar.2017.00658
8.    Rahmatullah M. Azam MN. Khatun Z. Seraj S. Islam F. Rahman MA et al. Medicinal plants used for treatment of diabetes by the Marakh sect of the Garo tribe living in Mymensingh district, Bangladesh. Afr. J. Tradit. Complement Altern. Med. 2012; 9(3):  380–385. doi: 10.4314/ajtcam.v9i3.12
9.    Zheng XL. Xing FW. Ethnobotanical study on medicinal plants around Mt. Yinggeling, Hainan Island, China. J. Ethnopharmacol. 2009; 124(2):197–210. doi: 10.1016/j.jep.2009.04.042
10.    Mulaudzi RB. Ndhlala AR. Kulkarni MG. Staden J. Pharmacological properties and protein binding capacity of phenolic extracts of some venda medicinal plants used against cough and fever. J. Ethnopharmacol. 2012; 143(1):185–193. doi: 10.1016/j.jep.2012.06.022
11.    Kadir MF. Sayeed MSB. Mia MMK. Ethnopharmacological survey of medicinal plants used by traditional healers in Bangladesh for gastrointestinal disorders. J. Ethnopharmacol. 2013; 147(1):148–156.                        doi: 10.1016/j.jep.2013.02.023
12.    Sameer W. Rajesh G. Swati J. Sushma S. Kalpana J. Lannea coromandelica attenuates glucagon and oxyntomodulin mediated cAAMP formation in HEK cells stably expressing human glucagon receptor. Journal of herbal Medicine 2015; 5(3):153-157. doi:10.5530/ijper.55.2.88
13.    Imam MZ. Moniruzzaman M. Antinociceptive effect of ethanol extract of leaves of Lannea coromandelica. Journal of Ethnopharmacology 2014; 154(1):109-115. doi: 10.1016/j.jep.2014.03.032
14.    Sawarkar HA. Khadabadi SS. Banarase NB. Mulaey BP. Aswar PB. Anthelmintic activity of extracts of Trigonella Foenum Graecum Linn. Research J. Pharm and Tech. 2009; 2(1): 128-130.
15.    Khandelwal KR. Practical Pharmacognosy Techniques and Experiments. Nirali Prakashan; Pune. 2003.
16.    Kokate CK. Practical Pharmacognosy. Vallabh prakashan; Delhi. 2005:107–111.
17.    Ajaiyeoba EO. Onocha PA. Olarenwaju OT. Invitro anthelmintic properties of Buchholzia coriaceae and Gynandropsis gynandra extract. Pharm Biol 2001; 39(3):217- 220. doi.org/10.1076/phbi.39.3.217.5936
18.    Das SS. Dey M. Ghosh AK. Determination of Anthelmintic Activity of the Leaf and Bark Extract of Tamarindus Indica Linn. Indian J Pharm Sci. 2011; 73(1): 104-107. doi: 10.4103/0250-474X.89768
19.    Sabin S. Dijo D. Jahanara H. Anjusha MK. Merin B. An in vitro evaluation on anthelmintic activity of different extracts of Hemigraphis colorata leaves. Research J. Pharm and Tech. 2019; 12(9): 4394-4396. doi:10.5958/0974-360X.2019.00755.8
20.    Kousalya M. Geetha P. Jesuraja A. Vinoth KM. In-vitro study of anthelmintic activity of Eclipta prostrata (L) y various extracts. Research J. Pharm and Tech. 2017; 10(1):58-60. doi: 10.5958/0974-360X.2017.00014.2
21.    Rajesh R. Chitra K. Padmaa MP. In vitro anthelmintic activity of aerial parts of Aerva lanata Linn Juss. International Journal of Pharmaceutical Sciences and Drug Research 2010; 2(4): 269-271.
22.    Murugamani V. Raju L. Baska AR. Manjir SK and Girija GS. The new method developed for evaluation  of anthelmintic activity by housefly worms and compared with conventional earthworm method. ISRN pharmacology 2012; Article ID 709860. doi:10.5402/2012/709860
23.    Siju EN. Rajalakshmi GR. Hariraj N. Sreejith KR. Soumya S. Muneer EK. Premalatha K. In vitro anthelmitic activity of Mussaenda frondosa. Research J. Pharm and Tech. 2010; 3(1): 151-153.
24.    Williams AR. Fryganas C. Ramsay A. Mueller Harvey I. Thamsborg SM. Direct anthelmintic effects of condensed tannins from diverse plant sources against Ascaris suum. PLos one. 2014; 9(5): e97053. doi: 10.1371/journal.pone.0097053
25.    Martin RJ. Mode of action of anthelmintic drugs. Vet J 1997; 154:11-34. doi: 10.1016/s1090-0233(05)80005-x
26.    Athnasiadou S. Kyriazakis I. Jackson F. Coop RL. Direct anthelmintic effects of condensed tannins towards different gastrointestinal nematodes of sheep: In vitro and in vivo studies. Vet Parasitol. 2001; 99:205–219. doi: 10.1016/s0304-4017(01)00467-8
27.    Sreesha NN. Neeraja ED. Greeshma R. Meenu B. Alexeyena V. Comparative evaluation of the anthelmintic activity of Coriandrum sativum Linn. and Apium graveolens Linn. Research J. Pharm and Tech. 2017; 10(11): 3857- 3859. doi: 10.5958/0974-360X.2017.00699.0

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