Author(s):
Rajesh L. Dumpala, Akruti Khodakiya, Nishant A Oza, Nehal J. Shah, Snigdha Das Mandal, M. Lakshmi Prasuna, Rakesh kumar Parmar
Email(s):
rdumpala64@gmail.com
DOI:
10.52711/0974-360X.2022.00422 
Address:
Rajesh L. Dumpala1*, Akruti Khodakiya1, Nishant A Oza1, Nehal J. Shah2, Snigdha Das Mandal3, M. Lakshmi Prasuna4, Rakesh kumar Parmar5
1Dept of Pharmaceutical Science, RDIC - C. U. Shah University, Wadhwan, Gujarat, India.
2Dept of Pharmaceutical Chemistry and Quality Assurance - IPCPRC, Dharmaj, Gujarat, India.
3Faculty of Pharmacy, Parul Institute of Pharmacy and Research, Faculty of Pharmacy, Parul University, P.O Limda, Vadodra, Gujarat, India.
4Dept of Pharmaceutical Analysis and Quality Assurance, Sumandeep Vidyapeeth Deemed to be University, Piparia, Vadodara, Gujarat, India.
5Dept of Pharmaceutics, Sardar Patel College of Pharmacy, At post – Bakrol, Anand, Gujarat, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 6,
Year - 2022
ABSTRACT:
Aim of the current research work to conduct bio availability of Nicardipine Hydrochloride S-SMEDDS in rats, compare with pure drug and Marketed Formulation. Study is conducted by using Wistar rats. 3-Groups were divided into Set-A Pure Drug, Set B: Marketed formulation, Set C: Optimized formulation, Total 18 healthy rats were selected, 6 in each group with weight of 300±50g Rats were labeled by numbers. Blood samples were collected from Tail vein method at pre-determined time intervals then blood samples were analyzed by validated HPLC method. S-SMEDDS exhibit cmax at 1429.58±107.40ng/mL, tmax at 0.75Hr, AUC(0-t) at 3042.05±333.35 ng. min/ml and t1/2 at 3.49±0.016 hr. AUC and maximum plasma concentration of the S-SMEDDS is higher than pure Nicardipine Hydrochloride drug and marketed formulation it indicates S-SMEDDS produce more bioavailability than Nicardipine Hydrochloride powder.
Cite this article:
Rajesh L. Dumpala, Akruti Khodakiya, Nishant A Oza, Nehal J. Shah, Snigdha Das Mandal, M. Lakshmi Prasuna, Rakesh kumar Parmar. Bioavailability Study of Developed S-SMEDDS Formulation for Nicardipine Hydrochloride in Rats. Research Journal of Pharmacy and Technology. 2022; 15(6):2525-0. doi: 10.52711/0974-360X.2022.00422
Cite(Electronic):
Rajesh L. Dumpala, Akruti Khodakiya, Nishant A Oza, Nehal J. Shah, Snigdha Das Mandal, M. Lakshmi Prasuna, Rakesh kumar Parmar. Bioavailability Study of Developed S-SMEDDS Formulation for Nicardipine Hydrochloride in Rats. Research Journal of Pharmacy and Technology. 2022; 15(6):2525-0. doi: 10.52711/0974-360X.2022.00422 Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-26
REFERENCE:
1. Catarina M. Vieira T. Veiga F et al. Physicochemical characterization and in vitro dissolution behavior of Nicardipine Hydrochloride cyclodextrins inclusion compounds. Eur J Pharm Sci 2002; 15(1):79–88. doi.org/10.1016/s0928-0987(01)00208-1
2. Sharma R. Nathiya D. Sharma A et al. Assessment of wound healing activity of roots of Bauhinia variegata Linn by excision and incision model in Albino Rats. Asian Journal of Research in Pharmaceutical Sciences 2015; 5(3): 145-152.doi.org/10.5958/2231-5659.2015.00023.5
3. David S. Timmins P and Conway B et al. Impact of the counter ion on the solubility and physicochemical properties of salts of carboxylic acid drugs. Drug Dev Ind Pharm.2012; 38(1): 93-103.doi.org/10.3109/03639045.2011.592530
4. Bhandary P. Khan G. Aryal B et al. Non-Compartmental Pharmacokinetics Modelling of Amlodipine In Rats. Int. Res J Pharm. App Sci 2013; 3(5):120-126.
5. Nitin M. Girish M. Chetan M. Ather J, Krunal S. Krishna Kumar et al. Comparative Influence of Selected Antioxidants with Lansoprazole in Aspirin Induced Ulcer Model in Rats. Research J. Pharm. and Tech. 2011; 4(8):1273-1277.
6. Graham D. Dow D. Hall D. Alexander O. Mroszczak. Freedman D. et al. The metabolism and pharmacokinetics of Nicardipine Hydrochloride in man. Br. J. Clin. Pharmacol. 1985; 20(1):233-285.doi.org/10.1111/j.1365-2125.1985.tb05141.x
7. Leandro T. Clarissa C and Teresa D et al. Pharmacokinetic Plasma Profile and Bioavailability Evaluation of Gatifloxacin in Rats. Latin American Journal of Pharmacy.2008; 27(2):270-273.
8. Rihana Fathima H. Reddy N. et al. Effect of Asoka Bark (Saraca indica) and Custard Apple Pulp (Annona squamosa) on Wound Healing in Female Albino Rats. Research J. Pharm. and Tech. 2011; 4(6): 928-931.
9. Maurin M. Rowe S. Christopher A. Munir H. et al. Solubilization of Nicardipine Hydrochloride via complexation and salt formation: J Pharm Sci. 1994; 83(10): 1418-1420. doi.org/10.1002/jps.2600831011
10. Ashok P. Meyyanathan S. Vadivelan R. Jawahar N. et al. Nanosuspensions by Solid Lipid Nanoparticles method for the Formulation and in vitro/in vivo characterization of Nifedipine. Asian J. Res. Pharm. Sci. 2021; 11(1): 1-6.doi.org/10.5958/2231-5659.2021.00001.1
11. Meiling Q. Peng W. Xin J. Liquid chromatography–mass spectrometry method for the determination of Nicardipine Hydrochloride in human plasma. J Chromatogr B analyt technol biomed life sci. 2006; 830(1): 81–85. doi.org/10.1016/j.jchromb.2005.10.035
12. Mithun B. Pancholi S. Shelke N. et al. Oral bioavailability enhancement of a poor water-soluble drug by co-surfactant free self-emulsifying drug delivery system (SEDDS). Research J. Pharm. and Tech.2011; 4(10) :1557-1562.
13. Nanda A. Kalyan G. Mamatha T. et al. Study of Pharmacokinetic And Pharmacodynamic Drug – Drug Interaction Between Rosuvastatin And Glimepiride In Normal Rabbits. world journal of pharmacy and pharmaceuticalsciences.2014; (1):1218-1230. doi.org/10.2147/DDDT.S129586.
14. Vakhariya R. Talokar S. Salunkhe S. Magdum C. et al. Formulation Development and Optimization of Simvastatin Loaded Solid Lipid Nanoparticles. Asian J. Res. Pharm. Sci. 2017; 7(1): 49-52. doi.org/10.5958/2231-5659.2017.00008.X
15. Jagtap O. Godse V. Deshpande S. Deodhar M. et al. HPLC Determination Of Satranidazole In Rat Plasma. Asian Journal Of Chemistry.2011; 23(10):4317-4320.
16. Dumpala R.L et al. Solubility and dissolution enhancement of Erlotinib by liquisolid compact technique. International Journal of Pharma O2. 2020; 2(4): 0271-0270.
17. Giri T. Mishra S. Tripathi D. et al. Carriers used for the development of solid dispersion for poorly water-soluble drugs. Research J. Pharm. and Tech. 2011; 4(3):356-366.
18. Pomponio R, Gotti R. Fiori J. Mura P. Cirri M. Maestrelli F et al. Photostability studies on Nicardipine Hydrochloride cyclodextrin complexes by capillary electrophoresis. J Pharm and Biomed Anal. 2004; 35(2): 267–275. doi.org/10.1016/S0731-7085(03)00532-6
19. Karki D. Kulkarni G. Swamy S. Sheeba FR.F et al. Formulation and Evaluation of Mucoadhesive Buccal Tablets of Curcumin and its Bioavailability Study. Research J. Pharm. and Tech 2017, 10(12): 4121-4128. doi.org/10.5958/0974-360X.2017.00750.8
20. Rupender R. Karambir Singh D. Ilango K. Shaik S et al. Pharmacokinetic Studies of Ambroxol Hydrochloride Microspheres In Rats After Oral Administration. International Journal Of Research In Pharmacy And Chemistry.2012; 2(2):280-288.
21. Nitin M. Girish M. Chetan M. Ather J. Krunal S. Krishna Kumar et al. Comparative Influence of Selected Antioxidants with Lansoprazole in Aspirin Induced Ulcer Model in Rats. Research J. Pharm. and Tech.2011, 4(8): 1273-1277.
22. Farina P et al. Pharmacokinetics of Nicardipine in Animals. I. Absorption, Plasma Concentrations, and Excretion After Administration of Nicardipine to Rats, Mice, Rabbits, and Dogs. Journal of Cardiovascular Pharmacology. 1997; 29:S86-S96.
23. Dumpala RL and Khodakiya A et al. Formulation and statistical optimization of S-SMEDDS of nicardipine hydrochloride by using BBD and PCA design. Int J Pharm Sci & Res 2021. 12(3): 1860-74. doi.org/10.13040/IJPSR.0975-8232.12(3).1860-74
24. Budhwani A. Shrivastava B. Singhai A. Gupta P et al. Antihyperglycemic activity of ethanolic extract of leaves of Dioscorea japonica in STZ-induced diabetic rats. Research J. Pharm. and Tech.2012, 5(4): 553-557.
25. Wagner J. G. and Nelson E et al. Kinetic analysis of blood levels and urinary excretion in the absorptive phase after single doses of drug. Journal of Pharmaceutical Sciences. 1964; 53(11): 1392-1403.doi.org/10.1002/jps.2600531126.
26. Dalvi PB. Ingale PR. et al. An Approach for Enhancement of Solubility. World Journal of Pharmacy and Pharmaceutical sciences. 2014; 3(12): 434-446.
27. Patel BU. Modi DC. Shah PD et al. A Review International Journal of Advances in Pharmaceutics. 2017; 6(7): 110-113.
28. Patel AR. Vavia PR et al. Preparation and in vivo evaluation of SMEDDS (self-microemulsifying drug delivery system) containing fenofibrate. AAPS J. 2007; 9:E 344–52.doi.org/10.1208/aapsj0903041.
29. Shah U, Patel K et al. Effects of Strychnos potatorum Linn. seeds on Triton WR 1339 Induced Hyperlipidemia in Rats. Research J. Pharm. and Tech. 2012, 5(7): 901-904.