Author(s): Ihsanul Hafiz, Loura Novilia, Luthvia, Nurul Husna, Muhammad Fauzan Lubis

Email(s): ihsanulhafiz@helvetia.ac.id

DOI: 10.52711/0974-360X.2022.00421   

Address: Ihsanul Hafiz1*, Loura Novilia1, Luthvia1, Nurul Husna2, Muhammad Fauzan Lubis2
1Department of Pharmacology, Faculty of Pharmacy and Health, Institute Kesehatan Helvetia, Medan 20124, Indonesia.
2Bachelor of Pharmacy Program, Faculty of Pharmacy and Health, Institute Kesehatan Helvetia, Medan 20124, Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022


ABSTRACT:
Pagoda plant (Clerodendrum paniculatum L.) is a medicinal plant that is widely distributed in ASEAN countries, including Indonesia. Pagoda plants are believed to have good pharmacological activity. In this study, the antibacterial activity of pagoda leaves was tested against Propionibacterium acnes. The method used in this research is the antibacterial activity test utilizing agar diffusion using paper discs to assess the inhibitory power of the test substance. The test groups used were water, ethyl acetate, and n-hexane fractions, with each divided into concentrations of 1, 3, 5, 10, 15, and 20%. The positive control used was Clindamycin, and the negative control used was dimethyl sulfoxide solution (DMSO). The results obtained with the highest inhibition value were clindamycin with an inhibition diameter of 28.70+0.15mm, then by a water fraction of 20% with an inhibitory diameter of 14.20+0.20mm. The study results concluded that the antibacterial activity of each fraction of the pagoda leaves was not vigorous in inhibiting the growth of Propionibacterium acnes bacteria.


Cite this article:
Ihsanul Hafiz, Loura Novilia, Luthvia, Nurul Husna, Muhammad Fauzan Lubis. Antibacterial Activity of Water, Ethyl Acetate and n-Hexane Fractions of Pagoda leaves (Clerodendrum paniculatum L.) against Propionibacterium acnes. Research Journal of Pharmacy and Technology. 2022; 15(6):2521-4. doi: 10.52711/0974-360X.2022.00421

Cite(Electronic):
Ihsanul Hafiz, Loura Novilia, Luthvia, Nurul Husna, Muhammad Fauzan Lubis. Antibacterial Activity of Water, Ethyl Acetate and n-Hexane Fractions of Pagoda leaves (Clerodendrum paniculatum L.) against Propionibacterium acnes. Research Journal of Pharmacy and Technology. 2022; 15(6):2521-4. doi: 10.52711/0974-360X.2022.00421   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-25


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