Author(s): Karina C. Rani, Titin U. Hasanah, Baqrotul Ilmiah, Nikmatul I. E. Jayani

Email(s): nikmatul.ikhrom@staff.ubaya.ac.id

DOI: 10.52711/0974-360X.2022.00420   

Address: Karina C. Rani1, Titin U. Hasanah2, Baqrotul Ilmiah3, Nikmatul I. E. Jayani4*
1Departement of Pharmaceutics, Faculty of Pharmacy, University of Surabaya, Surabaya, Indonesia.
2,3Faculty of Pharmacy, University of Surabaya, Surabaya, Indonesia.
4Department of Pharmaceutical Biology, Faculty of Pharmacy, University of Surabaya, Surabaya, Indonesia.
*Corresponding Author

Published In:   Volume - 15,      Issue - 6,     Year - 2022


ABSTRACT:
Introduction: Chewable gummy tablets are generally formulated with gelling agents such as pectin, gelatin, Na-alginate, and sugar. The selection of the appropriate carrier has a significant effect on the rheological properties of the product. Objective: To analyze the effect of different concentrations of Na-alginate and pectin on the physical characteristics of the preparation. Methods: In this research, 6 formulas were developed, namely Formula 1, 2, and 3 (with Na-alginate concentration of 6%, 7%, and 8%, respectively), Formula 4, 5, and 6 (with pectin concentration of 6%, 8, and 10%, respectively) and the active ingredient of ethanolic extract of moringa leaf (Moringa oleifera L.) extract. The evaluation of the preparation consisted of organoleptic test, pH, swelling ratio, dissolving time, weight variation, tablet dimension, and texture analysis (gumminess and chewiness). Results: The organoleptic test of the preparation showed that the preparation has square shape, green color, melon scent, sweet taste, and chewy texture. The pH value ranges from 5.06 ± 0.02 to 5.12 ± 0.04. The swelling ratio for Na-alginate carrier is between 20.00 ± 1.00% to 21.67 ± 0.58% while for pectin carrier ranges from 1.88 ± 0.24% to 2.08 ± 0.33%. The dissolving time ranges from 19.11 ± 0.19 minutes to 25.08 ± 0.02 minutes. The weight variation has an acceptance value between 3.96 ± 1.15 to 9.53 ± 1.16. Dimensions of Length, Width, and Thickness range from 1.50 cm x 1.50 cm x 1 cm. Texture analysis (Gumminess and Chewiness) on Na-alginate carrier is between 103.82 to 146.37 (Nxmm) and 46.24 to 146.37 (Nxmm), while on pectin carrier is between 90.4 to 1081.27 (Nxmm) and 36.16 to 3243.82 (N x mm). Conclusion: Swelling ratio, dissolving time, gumminess, and chewiness increase related to the concentration of Na-alginate and pectin. Na-alginate has a potential as a carrier for chewable gummy tablets at a concentration of 6%-7%. Meanwhile, pectin has a potential as a carrier with a concentration of 6%-10% in the development of chewable gummy tablets.


Cite this article:
Karina C. Rani, Titin U. Hasanah, Baqrotul Ilmiah, Nikmatul I. E. Jayani. Formulation of Moringa Extract Chewable Gummy Tablet with Na-Alginate and Pectin as Carriers. Research Journal of Pharmacy and Technology. 2022; 15(6):2513-0. doi: 10.52711/0974-360X.2022.00420

Cite(Electronic):
Karina C. Rani, Titin U. Hasanah, Baqrotul Ilmiah, Nikmatul I. E. Jayani. Formulation of Moringa Extract Chewable Gummy Tablet with Na-Alginate and Pectin as Carriers. Research Journal of Pharmacy and Technology. 2022; 15(6):2513-0. doi: 10.52711/0974-360X.2022.00420   Available on: https://rjptonline.org/AbstractView.aspx?PID=2022-15-6-24


REFERENCES:
1.    Jalili T, Medeiros DM and Wildman REC. Dietary fiber and coronary heart disease. in Handbook of Nutraceuticals and Functional Foods, Edited by Wildman REC. CRC Press Taylor & Francis Group, Boca Raton. 2016; 2nd ed: 131-142.
2.    Pathak Y. Nutraceuticals: Definitions, Formulations, and Challenges. in Handbook of Nutraceuticals, Edited by Pathak Y. CRC Press Taylor & Francis Group, Boca Raton. 2010; 1st ed: 15-25
3.    Webb GP. Dietary Supplements and Functional Foods: Second Edition. Blackwell Publishing Ltd, London. 2013.
4.    Takaoka S, Ogasawara K and Moriyama H. Production of Nattokinase as a Fibrinolytic Enzyme by an Ingenious Fermentation Technology: Safety and Efficacy Studies in Biotechnology. in Functional Foods and Nutraceuticals, Edited by Bagchi D, Lau FC and Ghosh DK. CRC Press Taylor & Francis Group, Boca Raton. 2010; 1st ed: 331-348.
5.    Shamim Q, Jitendra P, Reddy A, Safiullah S and Mohapatra P. Phytochemicals and Pharmacological Activities of Moringa oleifera Lam. Research Journal of Pharmacology and Pharmacodynamics. 2010; 2(2):183-186.
6.    El-Sohaimy SA, Hamad GM, Mohamed SE, Amar MH and Al-hindi RR. Biochemical and functional properties of Moringa oleifera leaves and their potential as a functional food. Global Advanced Research Journal of Agricultural Science. 2015; 4(4):188–99.
7.    Pachava VR, Krishnamurthy PT, Dahapal SP and Chinthamaneni PK. An updated review on “Miracle tree”: Moringa oleifera. Research Journal of Pharmacognosy and Phytochemistry. 2018;10(1):101-108. doi: 10.5958/0975-4385.2018.00016.X.
8.    Sahay S, Yadav U and Srinivasamurthy S. Potential of Moringa oleifera as a functional food ingredient: A review. International Journal of Food Science and Nutrition. 2017; 2(5): 31-37.
9.    Dhimmar N, Patel NM, Gajera V and Lambole V. Pharmacological activities of Moringa oleifera: An overview. Research Journal of Pharmacy and Technology. 2015; 8(4): 476–80. doi: 10.5958/0974-360X.2015.00079.7
10.    Masum NH, Hamid K, Zulfiker AH, Hossain K and Urmi KF. In vitro Antioxidant Activities of Different parts of the Plant Moringa oleifera Lam. Research Journal of Pharmacy and Technology. 2012; 5(12): 1532-1537.
11.    Mehwish HM, Riaz Rajoka MS, Xiong Y, Zheng K, Xiao H, Anjin T, Liu Z, Zhu Q and He Z. Moringa oleifera–A Functional Food and Its Potential Immunomodulatory Effects. Food Reviews International. 2020;36(7): 1-20. doi:10.1080/87559129.2020.1825479
12.    Panya T, Chansri N and Daodee S. Development and evaluation of lozenge from Moringa oleifera leaf extract. Research Journal of Pharmacy and Technology. 2016; 9(7): 805–9. doi: 10.5958/0974-360X.2016.00154.2
13.    Akhtar S and Dev P. Formulation And Evaluation Of Chewable Multivitamin Tablet. International Journal of Current Pharmaceutical Research. 2017; 9(4): 61-64. doi: 10.22159/ijcpr.2017v9i4.20958
14.    Arifa-Begum SK, Padma SV, Anusha V, Keerthi VZ, Vinitha SP, Prameela K, Nazeema MD and Padmaltha K. Formulation and evaluation of pediatric oral soft jellies of salbutamol sulphate. Research Journal of Pharmacy and Technology. 2018;11(11): 4939–4945. doi: 10.5958/0974-360X.2018.00899.5
15.    Vergara-Jimenez M, Almatrafi MM and Fernandez ML. Bioactive components in Moringa oleifera leaves protect against chronic disease. Antioxidants. 2017; 6(4). 1-13. doi: 10.3390/antiox6040091
16.    Čižauskaite U, Jakubaityte G, Žitkevičius V and Kasparavičiene G. Natural ingredients-based gummy bear composition designed according to texture analysis and sensory evaluation in vivo. Molecules 2019; 24(7). 1-16. doi: 10.3390/molecules24071442.
17.    Yadav P, Pandey P, Parashar S and Neeta. Pectin as Natural Polymer: An overview. Research Journal of Pharmacy and Technology. 2017; 10(4):1225-1229. doi: 10.5958/0974-360X.2017.00219.0.
18.    Lersch M. Texture – A hydrocolloid recipe collection. Creative Commons, California. 2014.
19.    Desai J, Patil J, Kulkarni R, Marapur S and Dalavi V. Alginate-Based Microparticulate Oral Drug Delivery System for Rifampicin. Research Journal of Pharmacy and Technology. 2009; 2(2): 301–303.
20.    Szekalska M, Puciłowska A, Szymańska E, Ciosek P, and Winnicka K. Alginate: Current Use and Future Perspectives in Pharmaceutical and Biomedical Applications. International Journal of Polymer Science. 2016; 2016(2): 1-17. doi: 10.1155/2016/7697031.
21.    Engsuwan J, Waranuch N, Limpeanchob N and Ingkaninan K. HPLC methods for quality control of Moringa oleifera extract using isothiocyanates and astragalin as bioactive markers. Science Asia. 2017; 43(3):169–174. doi: 10.2306/scienceasia1513-1874.2017.43.169
22.    Setiawan F, Yunita O and Kurniawan A. Uji Aktivitas Antioksidan Ekstrak Etanol Kayu Secang (Caesalpinia sappan) Menggunakan Metode DPPH, ABTS dan FRAP. Media Pharmaceutica Indonesiana. 2018; 2(2): 82-89.  
23.    Kadhim ZM and Ali WK. Preparation and evaluation of granisetron chewable pediatric oral jelly. International Journal of Drug Delivery Technology. 2019; 9(3):145–149. doi: 10.25258/ijddt.v9i3.4.
24.    Carneiro SB, Duarte FÍC, Heimfarth L, Quintans JDSS, Quintans-Júnior LJ, Júnior VFDV and Neves-de-Lima AA. Cyclodextrin-drug inclusion complexes: In vivo and in vitro approaches. International Journal of Molecular Sciences. 2019; 20(3): 1–23. doi: 10.3390/ijms20030642.
25.    Juliantoni Y, Wirasisya DG and Hasina R. Formulasi Nutraseutikal Sediaan Gummy Candies Sari Buah Duwet (Syzygium cumini). 2018; 7(2): 9–11.
26.    Prakash K, Satyanarayana VM, Nagiat HT, Fathi AH, Shanta AK and Prameela AR. Formulation development and evaluation of novel oral jellies of carbamazepine using pectin, guar gum, and gellan gum. Asian Journal of Pharmaceutics. 2014; 8(4): 241–249. doi:10.22377/ajp.v8i4.450.
27.    Kowalski G, Kijowska K, Witczak M, Kuterasiński L and Lukasiewicz M. Synthesis and effect of structure on swelling properties of hydrogels based on high methylated pectin and acrylic polymers. Polymers (Basel). 2019;11(1):1–16. doi: 10.3390/polym11010114.
28.    Hingmire LP, Deshmukh VN and Sakarkar DM. Development and Evaluation of Sustained Release Matrix Tablets Using Natural Polymer as Release Modifier. Research Journal of Pharmacy and Technology. 2008; 1(3):193–196.
29.    Ministry of Health of the Republic of Indonesia. Farmakope Indonesia Edisi VI. Kementrian Kesehatan Republik Indonesia, Jakarta. 2020.
30.    Augsburger LL and Hoag SW. Pharmaceutical Dosage Forms - Tablets. In: Pharmaceutical Dosage Forms: Tablets, Edited by Augsburger LL and Hoag SW. Informa Healthcare, New York. 2008; 2nd ed: 570.
31.    Phongpaichit, Nikom S, Rungjindamai J, Sakayaroj N, Hutadilok-Towatana J, Rukachaisirikul N, Kirtikara V and Kanyawim. Biological activities of extracts from endophytic fungi isolated from Garcinia plants. FEMS Immunology and Medical Microbiology. 2007; 51(3): 517–525. doi: 10.1111/j.1574-695X.2007.00331.x.
32.    Charde RM, Charde MS, Fulzele SV, Satturwar PM, Kasture AV and Joshi SB. Evaluation of ethanolic extract of Moringa oleifera for wound healing, anti-inflammatory and antioxidant activities on rats. Research Journal of Pharmacy and Technology. 2011; 4(2): 254–258.
33.    Saha S, Tomaro-Duchesneau C, Daoud JT, Tabrizian M and Prakash S. Novel probiotic dissolvable carboxymethyl cellulose films as oral health biotherapeutics: In vitro preparation and characterization. Expert Opinion on Drug Delivery. 2013; 10(11): 1471–1482. doi: 10.1517/17425247.2013.799135.
34.    Evageliou V, Richardson RK and Morris ER. Effect of pH, sugar type and thermal annealing on high-methoxy pectin gels. Carbohydrate Polymers. 2000; 42(3): 245–259. doi: 10.1016/S0144-8617(99)00191-5.
35.    Chuang JJ, Huang YY, Lo SH, Hsu TF, Huang WY, Huang SL and Lin YS. Effects of pH on the Shape of Alginate Particles and Its Release Behavior. International Journal of Polymer Science. 2017; 2017 (1). 1-10. doi: 10.1155/2017/3902704.
36.    Arabshahi-DS, Vishalakshi DD and Urooj A. Evaluation of antioxidant activity of some plant extracts and their heat, pH and storage stability. Food Chemistry. 2007; 100(3): 1100–1105. doi:10.1016/j.foodchem.2005.11.014.
37.    Manjula B, Varaprasad K, Sadiku R and Raju KM. Preparation and characterization of sodium alginate-based hydrogels and their in vitro release studies. Advance in Polymer Technology. 2013; 32(2):1–12. doi: 10.1002/adv.21340.
38.    Ramdhan T, Ching SH, Prakash S and Bhandari B. Physical and mechanical properties of alginate based composite gels. Trends in Food Science and Technology. 2020; 106(October):150–159. doi:10.1016/j.tifs.2020.10.002.
39.    Kaya AOW, Suryani A, Santoso J and Rusli MS. Karakteristik Dan Struktur Mikro Gel Campuran. J Kimia dan Kemasan. 2015; 37(1): 19–28.
40.    Muhammad NWF, Nurrulhidayah AF, Hamzah MS, Rashidi O and Rohman A. Physicochemical properties of dragon fruit peel pectin and citrus peel pectin: A comparison. Food Research. 2020; 4: 266–273. doi: 10.26656/fr.2017.4(S1).S14.
41.    Utomo BSB, Darmawan M, Hakim AR and Ardi DT. Physicochemical Properties And Sensory Evaluation Of Jelly Candy Made From Different Ratio Of K-Carrageenan And Konjac. Squalen Bulletin of Marine and Fisheries Postharvest and Biotechnology. 2014; 9(1): 25-34. doi: 10.15578/squalen.v9i1.93.
42.    Mahat MM, Sabere ASM, Shafiee SA, Nawawi MA, Hamzah HH, Jamil MAFM, Che-Roslan N, Abdul-Halim MI and Safian MF. The Sensory Evaluation and Mechanical Properties of Functional Gummy in the Malaysian Market. Preprints. 2020; (October): 1-11. doi: 10.20944/preprints202010.0213.v1.
43.    Kusumaningrum A, Parnanto NHR and Atmaka W. Kajian Pengaruh Variasi Konsentrasi Karaginan-Konjak Sebagai Gelling Agent Terhadap Karakteristik Fisik, Kimia Dan Sensoris Permen Jelly Buah Labu Kuning (Cucurbita maxima). Jurnal Teknosains Pangan. 2016; 5(1):1–11.
44.    Amelia O, Astuti S and Zulferiyenni. Pengaruh penambahan pektin dan sukrosa terhadap sifat kimia dan sensori selai jambu biji merah (Psidium guajava L.). Prosisding Seminar Nasional Pengembangan Teknologi Pertanian. 2016; (September):149–59.
45.    Roopa BS and Bhattacharya S. Alginate gels: I. Characterization of textural attributes. Journal Food Engineering. 2008; 85(1):123–131. doi:10.1016/j.jfoodeng.2007.07.012

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